Metabolism and Effects of Epidermal Growth Factor and Related Growth Factors in Mammals*

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Epidermal Growth Factor

1979 • 2,964 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Pathways of Protein Secretion in Eukaryotes

1985 • 1,050 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Isolation and structure of urogastrone and its relationship to epidermal growth factor

1975 • 751 citations

Enhancement of Wound Healing by Topical Treatment with Epidermal Growth Factor

1989 • 673 citations

Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor

1984 • 666 citations

Growth factors and the regulation of bone remodeling.

1988 • 614 citations

Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family

1989 • 586 citations

Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues

1985 • 568 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism.

1989 • 528 citations

Terminal differentiation of cultured human epidermal cells

1977 • 521 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Biologically active polypeptides in submandibular glands.

1980 • 474 citations

The stimulation of epidermal proliferation by a specific protein (EGF)

1965 • 421 citations

Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets.

1983 • 414 citations

Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure.

1989 • 400 citations

Epidermal Growth Factor: Effects of Androgens and Adrenergic Agents

1974 • 393 citations

Cloning and sequence analysis of a cDNA for rat transforming growth factor-α

1985 • 388 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

A vaccine candidate from the sexual stage of human malaria that contains EGF-like domains

1988 • 375 citations

Human squamous cell lung cancers express increased epidermal growth factor receptors.

1984 • 371 citations

Induction of transforming growth factor-α in activated human alveolar macrophages

1988 • 359 citations

The Hypercalcemia of Cancer

1984 • 352 citations

Human epidermal growth factor precursor: cDNA sequence, expressionin vitroand gene organization

1986 • 321 citations

Epidermal Growth Factor Is a Major Growth-Promoting Agent in Human Milk

1980 • 315 citations

The Stimulation of Epidermal Keratinization by a Protein Isolated from the Submaxillary Gland of the Mouse**From the Department of Biochemistry and the Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee.

1963 • 310 citations

Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor

1987 • 297 citations

Altered [125I] Epidermal Growth Factor Binding and Receptor Distribution in Psoriasis

1986 • 289 citations

Identification of Human Uromodulin as the Tamm-Horsfall Urinary Glycoprotein

1987 • 273 citations

Influence of Estrogens on Mouse Uterine Epidermal Growth Factor Precursor Protein and Messenger Ribonucleic Acid

1988 • 273 citations

Biological effects of epidermal growth factor, with emphasis on the gastrointestinal tract and liver: An update

1989 • 272 citations

Epidermal growth factor stimulates prostaglandin production and bone resorption in cultured mouse calvaria

1978 • 271 citations

Epidermal Growth Factor Immunoreactive Material in the Central Nervous System: Location and Development

1984 • 266 citations

The angiogenic activity of the fibroblast and epidermal growth factor

1979 • 261 citations

Epidermal growth factor regulates the expression of its own receptor.

1985 • 253 citations

Cultured epithelial cells of cornea, conjunctiva and skin: absence of marked intrinsic divergence of their differentiated states

1977 • 249 citations

Epidermal growth factor and transforming growth factor α

1989 • 247 citations

Purification and characterization of vaccinia virus growth factor

1985 • 238 citations

Immunocytochemical localization of human epidermal growth factor/urogastrone in several human tissues.

1985 • 235 citations

Melanoma, Growth Factors, Acanthosis Nigricans, the Sign of Leser-Trélat, and Multiple Acrochordons

1987 • 235 citations

Ductal morphogenesis in the mouse mammary gland: Evidence supporting a role for epidermal growth factor

1988 • 232 citations

Epidermal growth factor and thyrotropin-releasing hormone act similarly on a clonal pituitary cell strain. Modulation of hormone production and inhibition of cell proliferation

1980 • 226 citations

Radioimmunoassay of Epidermal Growth Factor

1972 • 226 citations

The Hormonal and Local Regulation of Bone Formation*

1983 • 226 citations

The ontogeny of epidermal growth factor receptors during mouse development

1984 • 213 citations

Presence of epidermal growth factor in human tears.

1989 • 213 citations

Computer-based characterization of epidermal growth factor precursor

1984 • 212 citations

Epidermal growth factor rapidly stimulates prolactin gene transcription

1982 • 208 citations

Growth Factors Modulate Gonadotropin Receptor Induction in Granulosa Cell Cultures

1981 • 207 citations

Epidermal growth factor binding and mitogenic activity on purified populations of cells from the central nervous system

1982 • 206 citations

A calcium-dependent 35-kilodalton substrate for epidermal growth factor receptor/kinase isolated from normal tissue.

1986 • 203 citations

Trophic action of epidermal growth factor on the pancreas and gastroduodenal mucosa in rats.

1982 • 203 citations

Epidermal growth factor stimulates DNA-synthesis of astrocytes in primary cerebellar cultures

1981 • 197 citations

Influence of Epidermal Growth Factor on the Development of Suckling Mouse Intestinal Mucosa

1982 • 194 citations

Epidermal growth factor and expression of specific genes: effects on cultured rat pituitary cells are dissociable from the mitogenic response.

1980 • 191 citations

Epidermal growth factor (EGF) stimulates EGF receptor synthesis.

1986 • 190 citations

Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development

1980 • 186 citations

INHIBITION OF OVARIAN AND TESTICULAR STEROIODOGENESIS BY EPIDERMAL GROWTH FACTOR

1981 • 184 citations

Epidermal Growth Factor (Urogastrone) in Human Fluids: Size Heterogeneity*

1979 • 183 citations

Radioimmunoassay of Human Epidermal Growth Factor (Urogastrone)1

1977 • 182 citations

lDirect Stimulation of Bone Resorption by Epidermal Growth Factor*

1980 • 182 citations

Epidermal Growth Factor (Urogastrone) in Human Tissues*

1979 • 182 citations

Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro.

1986 • 180 citations

Epidermal growth factor receptor immunoreactivity in rat brain. Development and cellular localization

1988 • 176 citations

Differential effects of epidermal growth factor and transforming growth factor-beta on synthesis of Mr = 35,000 surfactant-associated protein in fetal lung.

1987 • 170 citations

Epidermal Growth Factor Modulates Thyroid Growth and Function in Culture*

1983 • 170 citations

Epidermal Growth Factor and the Kidney

1989 • 169 citations

Human transforming growth factor-alpha stimulates bone resorption in vitro.

1985 • 169 citations

Effects of epidermal growth factor on lung maturation in fetal lambs.

1980 • 168 citations

Estrogen Regulation of Epidermal Growth Factor Receptor Messenger Ribonucleic Acid

1988 • 168 citations

Stimulation of prostaglandin E2 synthesis in cloned osteoblastic cells of mouse (MC3T3-E1) by epidermal growth factor.

1986 • 167 citations

Prostatic Epidermal Growth Factor Receptors and Their Regulation by Androgens*

1987 • 167 citations

Epidermal growth factor requirement for development of cultured mammary gland

1980 • 165 citations

Expression of Rat Transforming Growth Factor Alpha mRNA during Development Occurs Predominantly in the Maternal Decidua

1987 • 162 citations

Action of Testosterone on the Differentiation and Secretory Activity of a Target Organ: The Submaxillary Gland of the Mouse

1977 • 161 citations

Epidermal and Nerve Growth Factors in Mammalian Development

1981 • 154 citations

Functional EGF receptors are present on mouse embryo tissues

1981 • 154 citations

Amino acid sequence and domain structure of entactin. Homology with epidermal growth factor precursor and low density lipoprotein receptor.

1988 • 154 citations

Induction of c-fos and c-myc mRNA by epidermal growth factor or calcium ionophore is cAMP dependent.

1986 • 151 citations

Epidermal growth factor receptor number decreases during rat liver regeneration.

1981 • 151 citations

Developmental Expression of Rat Transforming Growth Factor-α mRNA

1985 • 147 citations

Phorbol Esters Stimulate Growth and Inhibit Differentiation in Cultured Thyroid Cells*

1985 • 142 citations

Modulation of cAMP-mediated differentiation in ovarian granulosa cells by epidermal growth factor and platelet-derived growth factor.

1983 • 141 citations

Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells.

1987 • 138 citations

Differential Expression of Transforming Growth Factor-α during Prenatal Development of the Mouse

1985 • 138 citations

Epidermal Growth Factor Stimulates Ornithine Decarboxylase Activity in the Digestive Tract of Mouse

1978 • 138 citations

Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine-containing peptide in a similar manner.

1982 • 137 citations

Selective binding of the epidermal growth factor and its specific effects on the epithelial cells of the cornea

1972 • 136 citations

Regulation of ovarian progestin production by epidermal growth factor in cultured rat granulosa cells.

1982 • 135 citations

Effects of epidermal growth factor on preimplantation mouse embryos

1989 • 133 citations

Circadian Phase-Dependent Stimulatory Effects of Epidermal Growth Factor on Deoxyribonucleic Acid Synthesis in the Duodenum, Jejunum, Ileum, Caecum, Colon, and Rectum of the Adult Male Mouse*

1980 • 132 citations

Rat epidermal growth factor: complete amino acid sequence

1985 • 132 citations

Characterization of the Binding Protein for Epidermal Growth Factor

1974 • 131 citations

Hepatic sequestration and biliary secretion of epidermal growth factor: evidence for a high-capacity uptake system.

1983 • 131 citations

Epidermal growth factor and transforming growth factor .alpha. bind differently to the epidermal growth factor receptor

1989 • 130 citations

Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit.

1990 • 129 citations

The role of epithelial growth factor in mammary gland development in vitro

1969 • 128 citations

Enhancement of intestinal growth in neonatal rats by epidermal growth factor in milk

1987 • 128 citations

Epidermal growth factor receptor gene promoter. Deletion analysis and identification of nuclear protein binding sites.

1988 • 127 citations

EPIDERMAL GROWTH FACTOR STIMULATES SECRETION OF HUMAN CHORIONIC GONADOTROPIN BY CULTURED HUMAN CHORIOCARCINOMA CELLS

1978 • 126 citations

Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth

1983 • 124 citations

EGF induces biphasic S6 kinase activation: Late phase is protein kinase C-dependent and contributes to mitogenicity

1989 • 122 citations

Human and Bovine Milk Contain Different Sets of Growth Factors*

1984 • 118 citations

Production of parathyroid hormone-like peptide in a human osteosarcoma cell line: stimulation by phorbol esters and epidermal growth factor

1989 • 118 citations

Selective Inhibition of Type I Collagen Synthesis in Osteoblastic Cells by Epidermal Growth Factor*

1984 • 117 citations

Renal origin of rat urinary epidermal growth factor

1984 • 116 citations

Inhibin Production by Primary Sertoli Cell-Enriched Cultures: Regulation by Follicle-Stimulating Hormone, Androgens, and Epidermal Growth Factor*

1988 • 115 citations

Hormonal Control of Epidermal Growth Factor Receptors by Gonadotropins during Granulosa Cell Differentiation

1987 • 114 citations

The effects of growth factors and serum on DNA synthesis and differentiation in thyroid cells in culture

1984 • 114 citations

Hormonal factors and liver growth

1978 • 114 citations

Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle

1984 • 113 citations

Differences in Human Skin Between the Epidermal Growth Factor Receptor Distribution Detected by EGF Binding and Monoclonal Antibody Recognition

1985 • 113 citations

Evidence for glomerular actions of epidermal growth factor in the rat.

1988 • 112 citations

Epidermal growth factor controls the proliferation and the expression of differentiation in canine thyroid cells in primary culture

1982 • 112 citations

Recombinant Human Epidermal Growth Factor Precursor Is a Glycosylated Membrane Protein with Biological Activity

1989 • 111 citations

Reduced renal prepro-epidermal growth factor mRNA and decreased EGF excretion in ARF

1989 • 111 citations

Concentrations of Epidermal Growth Factor, Nerve Growth Factor, and Submandibular Gland Renin in Male and Female Mouse Tissue and Fluids*

1979 • 110 citations

Onset of endogenous synthesis of epidermal growth factor in neonatal mice

1987 • 110 citations

Stimulation of pancreatic acinar cell growth by CCK, epidermal growth factor, and insulin in vitro

1986 • 109 citations

Epidermal growth factor receptor immunoreactivity in rat brain astrocytes. Response to injury

1988 • 106 citations

Effect of Epidermal Growth Factor on Bone Formation inVitro*

1979 • 104 citations

Immunocytochemical localization of epidermal growth factor in mouse kidney.

1986 • 104 citations

The identification of urogastrone in serum, saliva, and gastric juice

1979 • 98 citations

Effect of epidermal growth factor on ontogeny of the gastrointestinal tract

1985 • 98 citations

Localization of epidermal growth factor precursor in tooth and lung during embryonic mouse development

1989 • 98 citations

Transport of epidermal growth factor by rat liver: evidence for a nonlysosomal pathway.

1984 • 96 citations

A comparison of the responses of cultured myoblasts and chondrocytes to fibroblast and epidermal growth factors

1977 • 95 citations

Identification of Epidermal Growth Factor-Like Activity in Human Male Reproductive Tissues and Fluids*

1984 • 95 citations

The development of rat palatal shelves in vitro

1975 • 94 citations

Concentrations of epidermal growth factor in mouse milk throughout lactation

1983 • 93 citations

Mechanism of the Inhibitory Action of Epidermal Growth Factor on Testicular Androgen Biosynthesis in Vitro*

1982 • 93 citations

Synthesis and storage of epithelial-epidermal growth factor in submaxillary gland.

1971 • 93 citations

Epidermal growth factor in human milk: Daily production and diurnal variation during early lactation in mothers delivering at term and at premature gestation

1983 • 92 citations

Effect of Mouse Epidermal Growth Factor/Urogastrone on the Functional Maturation of Rat Intestine*

1983 • 91 citations

Influence of Epidermal Growth Factor on Fetal Rat Lung Development in Vitro

1986 • 90 citations

Effects of epidermal growth factor on osteoblastic cellsin vitro

1983 • 89 citations

Regulation of Epidermal Growth Factor Receptor Gene Expression by Retinoic Acid and Epidermal Growth Factor

1989 • 89 citations

A New Epidermal Growth Factorlike Domain in the Human Core Protein for the Large Cartilage-specific Proteoglycan

1989 • 88 citations

Location of Epidermal Growth Factor Receptors on Porcine Thyroid Follicle Cells and Receptor Regulation by Thyrotropin*

1986 • 87 citations

Differential phenotypic expression induced in cultured rat astroblasts by acidic fibroblast growth factor, epidermal growth factor, and thrombin

1989 • 87 citations

Regulation of uterine epidermal growth factor (EGF) receptors by estrogen in the mature rat and during the estrous cycle

1989 • 86 citations

Evidence for physiological function of epidermal growth factor: pregestational sialoadenectomy of mice decreases milk production and increases offspring mortality during lactation period.

1984 • 86 citations

Epidermal Growth Factor Receptor Levels in Mouse Mammary Glands in Various Physiological States*

1985 • 86 citations

Effects of enterally fed epidermal growth factor on the small and large intestine of the suckling rat

1987 • 85 citations

Effect of Thyroxine, Testosterone, and Corticosterone on Nerve Growth Factor (NGF) and Epidermal Growth Factor (EGF) Concentrations in Adult Female Mouse Submaxillary Gland: Dissociation of NGF and EGF Responses*

1981 • 84 citations

Immunocytochemical localization of epidermal growth factor in the developing human respiratory system and in acute and chronic lung disease in the neonate.

1989 • 84 citations

Effect of Thyroid Hormones on Epidermal Growth Factor Concentration in Neonatal Mouse Skin*

1983 • 84 citations

EFFECTS OF EPIDERMAL GROWTH FACTOR ON HAIR GROWTH IN THE MOUSE

1981 • 83 citations

Defective epidermal growth factor gene expression in mice with polycystic kidney disease

1990 • 82 citations

Epidermal Hyperplasia and Wool Follicle Regression in Sheep Infused with Epidermal Growth Factor

1985 • 80 citations

Mitogenic effect of epidermal growth factor on sheep thyroid cells in culture

1982 • 80 citations

Hormonal Regulation of Epidermal Growth Factor and Protease in the Submandibular Gland of the Adult Mouse*

1981 • 80 citations

Epidermal growth factor receptors in clonal lines of a rat osteogenic sarcoma and in osteoblast-rich rat bone cells

1983 • 80 citations

Quantitation of Epidermal Growth Factor in the Rat

1983 • 80 citations

Epidermal growth factor and bovine growth hormone stimulate differentiation and myelination of brain cell aggregates in culture

1985 • 79 citations

Regulation of epidermal growth factor receptor levels by thyroid hormone.

1984 • 79 citations

Epidermal growth factor and proliferation in rat hepatocytes in primary culture isolated at different times after partial hepatectomy.

1986 • 78 citations

Effect of oestradiol-17β on uterine epidermal growth factor concentration in immature mice

1984 • 78 citations

Epidermal growth factor-like proteins in breast fluid and human milk

1988 • 77 citations

Epidermal growth factor (EGF) stimulation of cultured brain cells. I. Enhancement of the developmental increase in glial enzymatic activity

1983 • 77 citations

Receptors for insulin and epidermal growth factor: Relation to synthesis of DNA in cultured rabbit lens epithelium

1975 • 75 citations

Urogastrone–epidermal growth factor concentrations in prostatic fluid of normal individuals and patients with benign prostatic hypertrophy

1986 • 74 citations

Biological action of epidermal growth factor and its functional receptors in normal mammary epithelial cells.

1983 • 74 citations

Epidermal Growth Factor Gene Expression Is Regulated Differently in Mouse Kidney and Submandibular Gland^*

1986 • 74 citations

Epidermal growth factor inhibits the hydroosmotic effect of vasopressin in the isolated perfused rabbit cortical collecting tubule.

1988 • 73 citations

Characterization of the High Molecular Weight Form of Epidermal Growth Factor

1974 • 72 citations

Size heterogeneity of epidermal growth factor in human body fluids

1987 • 70 citations

Treatment of the Neonatal Rat with Epidermal Growth Factor: Differences in Time and Organ Response

1986 • 70 citations

Accelerated Development of Salivary Glands of Early Postnatal Rats Following Isoproterenol.

1963 • 68 citations

Regulation of Epidermal Growth Factor Receptor Gene Expression

1989 • 67 citations

1,25-Dihydroxyvitamin D3 increases epidermal growth factor receptors and transforming growth factor beta-like activity in a bone-derived cell line.

1987 • 65 citations

Levels of epidermal growth factor in mice tissues measured by a specific radioreceptor assay

1976 • 63 citations

Epidermal growth factor and nerve growth factor in mouse saliva: A comparative study

1979 • 63 citations

Epidermal Growth Factor in Human Urine from Birth to Puberty*

1985 • 63 citations

Epidermal Growth Factor Precursor in Mouse Lactating Mammary Gland Alveolar Cells

1989 • 62 citations

Epidermal growth factor deficiency during pregnancy causes abortion in mice

1987 • 62 citations

Androgens and transforming growth factor β modulate the growth response to epidermal growth factor in human prostatic tumor cells (LNCaP)

1988 • 61 citations

Interaction of Epidermal Growth Factor With the Hypothalamic-Pituitary-Adrenal Axis: Potential Physiologic Relevance*

1988 • 59 citations

Aggressive behavior in adult male mice elevates serum nerve growth factor levels

1986 • 59 citations

Distribution of i.v. administered epidermal growth factor in the rat

1988 • 58 citations

Epidermal Growth Factor Immunoreactive Material in the Rat Brain

1989 • 56 citations

Alpha- and beta-adrenergic receptors of the rat salivary gland elevation after chemical sympathectomy

1979 • 56 citations

Characterization of Material With Epidermal Growth Factor Immunoreactivity in Human Serum and Platelets*

1989 • 56 citations

Growth of mouse mammary gland end buds cultured in a collagen gel matrix

1982 • 55 citations

Isoproterenol accelerates the postnatal differentiation of rat submandibular gland

1972 • 55 citations

Growth hormone enhances hepatic epidermal growth factor receptor concentration in mice.

1988 • 54 citations

IN VIVO Aspects of urogastrone-epidermal growth factor

1985 • 54 citations

Distribution of Epidermal growth factor binding sites in the adult rat anterior pituitary gland

1986 • 53 citations

Epidermal growth factor (EGF) and monoclonal antibody to cell surface EGF receptor bind to the same chromatin receptor

1989 • 52 citations

Plasma Growth Hormone Pattern Regulates Epidermal Growth Factor (EGF) Receptor Messenger Ribonucleic Acid Levels and EGF Binding in the Rat Liver*

1989 • 52 citations

Epidermal Growth Factor Stimulates Growth Hormone Secretion from Superfused Rat Adenohypophyseal Fragments

1984 • 51 citations

Binding of epidermal growth factor in rat pancreatic acini

1983 • 50 citations

Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat

1988 • 50 citations

Immunoreactive Human Epidermal Growth Factor in Human Pancreatic Juice*

1982 • 50 citations

Epidermal growth factor-like, corneal wound healing substance in mouse tears.

1988 • 50 citations

Primary cultures of rat pancreatic acinar cells in serum-free medium

1985 • 50 citations

Effects Of Resperpine, Epidermal Growth Factor, And Cyclic Nucleotide Modulators On Epidermal Mitosis

1976 • 49 citations

Epidermal growth factor has both growth-promoting and growth-inhibiting effects on physical and neurobehavioral development of neonatal mice

1989 • 49 citations

Liver epithelial cell migration induced by epidermal growth factor or transforming growth factor alpha is associated with changes in the gene expression of secreted proteins

1988 • 49 citations

Epidermal Growth Factor in Synaptosomal Fractions of Mouse Cerebral Cortex

1986 • 49 citations

Characterization of Epidermal Growth Factor Receptors in Astrocytic Glial and Neuronal Cells in Primary Culture*

1989 • 49 citations

Precocious development of granular convoluted tubules in the mouse submandibular gland induced by thyroxine or by thyroxine and testosterone

1980 • 48 citations

Hormonal modulation of mouse plasma concentration of epidermal growth factor

1984 • 46 citations

Epidermal growth factor deficiency associated with diabetes mellitus.

1989 • 46 citations

Urine and Kidney Epidermal Growth Factor: Ontogeny and Sex Difference in the Mouse

1985 • 46 citations

Epidermal Growth Factor, But Not Thyrotropin, Stimulates the Expression of c-fosand c-mycMessenger Ribonucleic Acid in Porcine Thyroid Follicle Cells in Primary Culture*

1988 • 45 citations

Thyroid hormone regulation of prolactin binding to mouse mammary glands

1979 • 45 citations

Structural analysis of the uEGF gene in the sea urchinStrongylocentrotus purpuratus reveals more similarity to vertebrate than to invertebrate genes with EGF-like repeats

1989 • 44 citations

The stimulation by epidermal growth factor (Urogastrone) of the growth of neonatal rat hepatocytes in primary tissue culture and its modulation by serum and associated pancreatic hormones

1980 • 44 citations

Effect of mouse epidermal growth factor on DNA and protein synthesis, progesterone and inhibin production by bovine granulosa cells in culture

1986 • 44 citations

EPIDERMAL GROWTH FACTOR STIMULATES PRODUCTION OF PROGESTERONE IN CULTURED HUMAN CHORIOCARCINOMA CELLS

1980 • 44 citations

The effects of epidermal growth factor on neural crest cells in tissue culture

1987 • 44 citations

Urogastrone and Lactose Concentrations in Precolostrum, Colostrum, and Milk

1983 • 43 citations

The source of urinary epidermal growth factor in humans

1988 • 43 citations

Epidermal growth factor receptor regulation in rat kidney: two models of renal growth

1989 • 43 citations

Human epidermal growth factor: renal production and absence from plasma

1988 • 42 citations

Epidermal Growth Factor-Binding Sites, Present in Normal Human and Rat Pituitaries, Are Absent in Human Pituitary Adenomas^*

1987 • 42 citations

Epidermal growth factor acts as a corticotropin-releasing factor in chronically catheterized fetal lambs.

1987 • 42 citations

Epidermal Growth Factor Enhances [125I]Iodo-Follicle-Stimulating Hormone Binding by Cultured Porcine Granulosa Cells*

1987 • 42 citations

Epidermal Growth Factor in Mouse Milk during Early Lactation: Lack of Dependency on Submandibular Glands

1985 • 42 citations

Epidermal Growth Factor: A Critical Factor in Fetal Maturation?

1981 • 41 citations

Effects of epidermal growth factor on bone formation and resorption in vivo

1990 • 41 citations

Aggressive behaviour in mice provokes a marked increase in both plasma epidermal growth factor and renin

1981 • 41 citations

Development of the digestive system: comparative animal studies

1985 • 41 citations

Epidermal growth factor stimulates secretion of rat pituitary luteinizing hormone in vitro

1985 • 41 citations

Ontogenesis of Nerve Growth Factor and Epidermal Growth Factor in Submaxillary Glands and Nerve Growth Factor in Brains of Immature Male Mice: Correlation with Ontogenesis of Serum Levels of Thyroid Hormones

1982 • 41 citations

Epidermal growth factor stimulates phospholipase A2 in vasopressin-treated rat glomerular mesangial cells

1988 • 41 citations

Epidermal growth factor binding and biologic effects on mouse pancreatic acini

1983 • 41 citations

Growth factor regulation of the renal cortical tubular cells by epidermal growth factor, insulin-like growth factor-I, acidic and basic fibroblast growth factor, and transforming growth factor-β in serum free culture

1989 • 41 citations

Exocrine secretion of epidermal growth factor by the rat prostate: Effect of adrenergic agents, cholinergic agents, and vasoactive intestinal peptide

1988 • 40 citations

Immunoreactive Human Epidermal Growth Factor Concentrations in Amniotic Fluid, Umbilical Artery and Vein Serum, and Placenta in Full-Term and Preterm Infants

1989 • 39 citations

Immunoelectron microscopy of epidermal growth factor in mouse kidney

1986 • 39 citations

CONVERSION OF HIGH MOLECULAR WEIGHT HUMAN EPIDERMAL GROWTH FACTOR (hEGF)/UROGASTRONE (UG) TO SMALL MOLECULAR WEIGHT hEGF/UG BY MOUSE EGF-ASSOCIATED ARGININE ESTERASE*

1979 • 38 citations

Stimulation of adrenal cortisol biosynthesis by epidermal growth factor

1983 • 38 citations

Effects of thyroxine and 5α-dihydrotesterone on the activities of various enzymes in the mouse submandibular gland

1978 • 38 citations

Mitogenic Activity and Epidermal Growth Factor Content in Human Milk

1985 • 37 citations

Epidermal Growth Factor Induces Activation of Protein Kinase FA and ATP.Mg-dependent Protein Phosphatase in A431 Cells

1989 • 36 citations

Effect of maturation on gastrointestinal absorption of epidermal growth factor in rats

1987 • 36 citations

Epidermal growth factor measurements in mouse plasma: method, ontogeny, and sex difference

1985 • 36 citations

EGF content in the gastrointestinal tract of rats: effect of age and fasting/feeding

1989 • 35 citations

Epidermal growth factor in mouse urine: non-blood origin, and increase by sialoadenectomy and T4 therapy

1985 • 35 citations

The Fate of [¹²⁵I]Iodoepidermal Growth Factor in Isolated Hepatocytes: A Quantitative Electron Microscopic Autoradiographic Study*

1981 • 35 citations

Effect of epidermal growth factor on growth and postnatal development of the rabbit liver

1987 • 33 citations

Factors influencing the growth of alveolar type II epithelial cells isolated from rat lungs

1982 • 33 citations

Thyroid Hormone Regulation of Epidermal Growth Factor Receptor Levels in Mouse Mammary Glands

1986 • 32 citations

The regulation by thyroid hormones and androgen of epidermal growth factor synthesis in the submandibular gland and its plasma concentrations in mice

1989 • 32 citations

Ontogeny of Epidermal Growth Factor Receptor/Kinase and of Lipocortin-1 in the Ovine Lung

1989 • 32 citations

Ontogeny of EGF Receptors During Postnatal Development of Mouse Small Intestine

1987 • 32 citations

Treatment of ewes at different stages of pregnancy with epidermal growth factor: effects on wool growth and plasma concentrations of growth hormone, prolactin, placental lactogen and thyroxine and on foetal development

1984 • 32 citations

[¹²⁵I]Iodo-Epidermal Growth Factor Binding and Mitotic Responsiveness of Porcine Granulosa Cells Are Modulated by Differentiation and Follicle-Stimulating Hormone*

1988 • 31 citations

Human urinary epidermal growth factor: Effects of age, sex and female endocrine status

1986 • 31 citations

Influence of age on epidermal growth factor receptor level in the rat brain

1988 • 31 citations

Glucocorticoids increase pulmonary Epidermal Growth Factor receptors in female and male fetal rabbit

1984 • 30 citations

Growth hormone regulates the rodent hepatic epidermal growth factor receptor at a pretranslational level

1989 • 30 citations

Epidermal Growth Factor: Effect on Circulating Thyroid Hormone Levels in Sheep*

1986 • 30 citations

Dexamethasone Acts as a Negative Regulator of Epidermal Growth Factor Receptor Synthesis in Fetal Rat Lung Cells

1989 • 30 citations

Isolation of rat epidermal growth factor (r-EGF): Chemical, biological and immunological comparisons with mouse and human EGF

1986 • 30 citations

Accumulation of Epidermal Growth Factor Receptors in Retinoic Acid-Treated Fetal Rat Lung Cells is Due to Enhanced Receptor Synthesis

1988 • 29 citations

Epidermal growth factor advances some aspects of development but retards others in both rats and hamsters.

1989 • 29 citations

Epidermal Growth Factor (EGF)-Like Transforming Growth Factor (TGF) Activity and EGF Receptors in Ovine Fetal Tissues: Possible Role for TGF in Ovine Fetal Development

1987 • 29 citations

Epidermal growth factor receptor defects in leprechaunism. A multiple growth factor-resistant syndrome.

1989 • 29 citations

Oral Epidermal Growth Factor Is Trophic for the Stomach in the Neonatal Rat

1987 • 28 citations

Effect of epidermal growth factor on the labeling of the various RNA species and of nuclear proteins in primary rat astroglial cell cultures

1988 • 28 citations

Characterization and localization of receptors for epidermal growth factor in ovine skin

1989 • 27 citations

Epidermal growth factor stimulates luteinizing hormone and arachidonic acid release in rat pituitary cells

1988 • 27 citations

Epidermal Growth Factor Increases Intestinal Calbindin-D_9kand 1,25-Dihydroxyvitamin D Receptors in Neonatal Rats*

1989 • 27 citations

Purification and characterization of epidermal growth factor (β-urogastrone) and epidermal growth factor fragments from large volumes of human urine

1985 • 27 citations

Dedifferentiation of cultured thyroid cells by epidermal growth factor: some insights into the mechanism

1987 • 26 citations

Influence of Epidermal Growth Factor on the Maturation of Fetal Rat Brain Cells in Aggregate Culture

1989 • 26 citations

The effects of epidermal growth factor on cell proliferation and prolactin production by GH₃ rat pituitary cells

1984 • 26 citations

Epidermal Growth Factor Receptors during Postnatal Development of the Mouse Colon*

1987 • 26 citations

Parathyroid Hormone Down-Regulates the Epidermal Growth Factor Receptors in Clonal Osteoblastic Mouse Calvarial Cells, MC3T3-E1: Possible Mediation by Adenosine 3',5'-Cyclic Monophosphate

1989 • 26 citations

Epidermal Growth Factor Stimulates (Pro-)Insulin Biosynthesis and³H-Thymidine Incorporation in Isolated Pancreatic Rat Islets

1986 • 25 citations

Epidermal Growth Factor in Mouse Ocular Tissue: Effects of Thyroxine and Exogenous Epidermal Growth Factor

1985 • 25 citations

Tissue-specific effects of castration and ovariectomy on murine epidermal growth factor and its mRNA

1989 • 25 citations

Structural analysis of the 5′-flanking sequence of the mouse epidermal growth factor gene

1988 • 24 citations

Purification and characterization of high molecular weight human epidermal growth factor from human urine

1987 • 23 citations

Epidermal Growth Factor in Neonatal Mouse Urine: Maturative Effect of Thyroxine

1984 • 22 citations

Evaluation of Murine Placental Degradation and Transfer of [¹²⁵I]Iodo-Epidermal Growth Factor

1987 • 21 citations

Signal Transduction by Epidermal Growth Factor Receptor

1988 • 21 citations

Presence of epidermal growth factor receptors on human thyroid membranes

1987 • 21 citations

The receptor for epidermal growth factor is present in human fetal kidney, liver and lung

1989 • 20 citations

Synergistic effects of thyroxine and glucocorticoid in induction of trypsin-like esteroprotease in mouse submandibular gland

1979 • 20 citations

Reinitiation of DNA synthesis in quiescent mouse keratinocytes; Regulation by polypeptide hormones, cholera toxin, dexamethasone, and retinoic acid

1988 • 20 citations

The fate and uptake of murine epidermal growth factor in the sheep

1989 • 20 citations

Epidermal Growth Factor Inhibits Rat Pancreatic Cell Proliferation, Causes Acinar Cell Hypertrophy, and Prevents Caerulein-Induced Desensitization of Amylase Release*

1989 • 19 citations

Characterization of hepatic epidermal growth factor receptors in the developing rat

1987 • 19 citations

Epidermal growth factor receptors in fetal and maternal rabbit lung

1982 • 19 citations

Interaction of epidermal growth factor with receptors on human and porcine thyroid membranes

1984 • 18 citations

Thyroid hormone regulation of adrenergic receptors and beta-adrenergic responsiveness in the rat submandibular gland

1984 • 18 citations

Maturational Changes and Origin of Urinary Human Epidermal Growth Factor in the Neonatal Period

1989 • 18 citations

Epidermal Growth Factor Binding to Neonatal Mouse Skin Explants and Membrane Preparations—Effect of Triiodothyronine

1985 • 17 citations

Induction of Epidermal Growth Factor by Tri-Iodo-L-Thyronine in the Submandibular Glands of Mice with Testicular Feminization

1981 • 16 citations

Epidermal Growth Factor Decreases Thyroid Hormone Receptors and Attenuates Thyroid Hormone Responses in GH₄C₁Cells*

1987 • 16 citations

Shope fibroma virus growth factor exhibits epidermal growth factor activities in newborn mice

1988 • 15 citations

Release of Human Epidermal Growth Factor from Platelets in Accordance with Aggregation in vitro.

1989 • 15 citations

Regulation of thyroid peroxidase activity by thyrotropin, epidermal growth factor and phorbol ester in porcine thyroid follicles cultured in suspension

1989 • 15 citations

Specific epidermal growth factor receptors on porcine thyroid cell membranes

1983 • 15 citations

Acquisition of urine, kidney and submandibular gland epidermal growth factor responsiveness to thyroxine administration in neonatal mice

1985 • 14 citations

Sexual dimorphism and testosterone effects on liver epidermal growth factor receptors in mice

1986 • 14 citations

Some properties of human epidermal growth factor (hEGF)-like immunoreactive material originating from platelets during blood coagulation.

1986 • 14 citations

A sensitive enzyme immunoassay system of rat epidermal growth factor in biological fluids and tissue extracts

1989 • 13 citations

Immunoreactive Human Epidermal Growth Factor in Human Seminal Plasma

1989 • 13 citations

Effect of epidermal growth factor on lung liquid secretion in fetal sheep.

1986 • 13 citations

Human epidermal growth factor concentrations in urine, but not in saliva and serum, depend on thyroid state

1987 • 12 citations

Epidermal growth factor receptor ontogeny in mice with congenital hypothyroidism.

1986 • 12 citations

Molecular characterization of the EGF receptor and involvement of glycosyl moieties in the binding of EGF to its receptor on a clonal osteosarcoma cell line, UMR 106-06

1986 • 12 citations

Thyroid Hormone Effects on Skin and Hepatic Epidermal Growth Factor Concentrations in Neonatal and Adult Mice

1984 • 12 citations

Neonatal Hyperthyroidism Alters Hepatic Epidermal Growth Factor Receptor Ontogeny in Mice

1988 • 11 citations

A mechanism for the in vitro stimulation of adrenal cortisol biosynthesis by epidermal growth factor

1985 • 11 citations

Epidermal growth factor in plasma, serum and urine before and after prolonged exercise

1988 • 11 citations

Growth hormone increases neonatal mouse urine epidermal growth factor

1984 • 10 citations

The Role of Epidermal Growth Factor in Skin Diseases

1988 • 10 citations

Retardation of growth and epithelial differentiation in suckling mice by anti-EGF antisera.

1989 • 10 citations

Effect of congenital renal disease and neonatal thyroid status on urinary human epidermal growth factor concentrations

1989 • 8 citations

Ontogenesis of epidermal growth factor in liver of BALB mice

1988 • 7 citations

Rat Epidermal Growth Factors: Purification and Tissue Content.

1989 • 7 citations

Mouse epidermal growth factor concentrations are altered by gonadectomy and treatments with estradiol and progesterone

1989 • 6 citations

Neonatal Hyperthyroidism in Mice Has Different Effects on Epidermal Growth Factor Levels in Submandibular Gland, Urine, and Blood

1986 • 5 citations

A sensitive enzyme immunoassay for human epidermal growth factor. Determination of hEGF in human serum and urine and pharmacokinetics in mouse.

1989 • 5 citations

Neonatal Hyperthyroidism Impairs Epinephrine- Provoked Secretion of Nerve Growth Factor and Epidermal Growth Factor in Mouse Saliva

1986 • 5 citations

Epidermal growth factor and tooth development.

1987 • 5 citations

Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++

1987 • 5 citations

Effect of thyroid hormone and sex status on epidermal growth factor concentrations in the submandibular gland of a congenitally hypothyroid mouse model.

1986 • 5 citations

Neonatal hyperthyroidism alters submandibular gland epidermal growth factor response to thyroxine in the adult mouse

1985 • 2 citations

A two-site solid phase enzyme immunoassay for rat epidermal growth factor.

1988 • 2 citations

Reduced urinary epidermal growth factor levels in Snell dwarf mutant mice

1986 • 2 citations