Mechanisms of action of calcium‐mobilizing agonists: some variations on a young theme

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle

1987 • 786 citations

Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes

1987 • 676 citations

The Role of Protein Kinase C in Transmembrane Signalling

1986 • 557 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.

1986 • 415 citations

Inositol phosphates: synthesis and degradation.

1988 • 359 citations

Stimulation of 1,2-diacylglycerol accumulation in hepatocytes by vasopressin, epinephrine, and angiotensin II.

1985 • 304 citations

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1987 • 303 citations

Direct G protein gating of ion channels

1988 • 258 citations

Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.

1987 • 253 citations

Identification and properties of two distinct phosphatidylinositol-specific phospholipase C enzymes from sheep seminal vesicular glands.

1982 • 248 citations

Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.

1985 • 245 citations

The kinetics of changes in intracellular calcium concentration in fura-2-loaded human platelets.

1987 • 245 citations

Bovine brain cytosol contains three immunologically distinct forms of inositolphospholipid-specific phospholipase C.

1987 • 233 citations

Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes.

1984 • 225 citations

Pathways of Ca2+ influx at the plasma membrane: Voltage-, receptor-, and second messenger-operated channels

1987 • 223 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Purification and characterization of a phosphoinositide-specific phospholipase C from guinea pig uterus. Phosphorylation by protein kinase C in vivo.

1987 • 161 citations

Signal transduction by G proteins

1990 • 159 citations

Regulation of the L-type calcium channel

1987 • 147 citations

Rapid increases in cytosolic free calcium in response to muscarinic stimulation of rat parotid acinar cells.

1987 • 124 citations

Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10.

1988 • 117 citations

Guanine nucleotides stimulate soluble phosphoinositide-specific phospholipase C in the absence of membranes.

1986 • 116 citations

Guanine-nucleotide and hormone regulation of polyphosphoinositide phospholipase C activity of rat liver plasma membranes. Bivalent-cation and phospholipid requirements

1987 • 112 citations

The relationships between receptor binding capacity for norepinephrine, angiotensin II, and vasopressin and release of inositol trisphosphate, Ca2+ mobilization, and phosphorylase activation in rat liver.

1985 • 109 citations

Purification of a phosphoinositide-specific phospholipase C from bovine brain.

1987 • 105 citations

A tumour promoter, 12-O-tetradecanoylphorbol 13-acetate, increases cellular 1,2-diacylglycerol content through a mechanism other than phosphoinositide hydrolysis in Swiss-mouse 3T3 fibroblasts

1987 • 93 citations

Isomers of inositol trisphosphate in exocrine pancreas

1986 • 55 citations

Receptor-mediated inositol phosphate formation in relation to calcium mobilization: a comparison of two cell lines.

1987 • 43 citations

Subsecond and second changes in inositol polyphosphates in GH4C1 cells induced by thyrotropin-releasing hormone

1987 • 43 citations

Modulations of voltage-dependent ion channels by extracellular signals

1987 • 42 citations

Modulation of Ion Channels by Phosphorylation and Second Messengers

1987 • 30 citations

Regulation of Phosphoinositide Breakdown

1988 • 2 citations

Deleted Work

1955 • 0 citations