An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation

Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

1992 • 530 citations

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex.

1993 • 510 citations

Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

1997 • 419 citations

Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.

1995 • 341 citations

Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells

1989 • 334 citations

Tyrosine Phosphorylation of p130Cas and Cortactin Accompanies Integrin-mediated Cell Adhesion to Extracellular Matrix

1995 • 289 citations

Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.

1994 • 276 citations

The Role of Tyrosine Phosphorylation of Cortactin in the Locomotion of Endothelial Cells

1998 • 271 citations

MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.

1995 • 269 citations

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.

1995 • 261 citations

Down-regulation of the Filamentous Actin Cross-linking Activity of Cortactin by Src-mediated Tyrosine Phosphorylation

1997 • 247 citations

A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.

1994 • 242 citations

Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation.

1996 • 188 citations

Binding and localization of M(r) 72,000 matrix metalloproteinase at cell surface invadopodia.

1993 • 182 citations

The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites.

1993 • 165 citations

Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro

1998 • 152 citations

Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells.

1992 • 136 citations

Cellular invasion into matrix beads: Localization of fa integrins and fibronectin to the invadopodia

1991 • 131 citations

Phagocytosis of cross-linked gelatin matrix by human breast carcinoma cells correlates with their invasive capacity.

1998 • 126 citations

Biology of the protein kinase C family

1989 • 120 citations

A Mechanism for Regulation of Melanoma Invasion

1996 • 117 citations

Differential Effects of Platelet-derived Growth Factor BB on p125 Focal Adhesion Kinase and Paxillin Tyrosine Phosphorylation and on Cell Migration in Rabbit Aortic Vascular Smooth Muscle Cells and Swiss 3T3 Fibroblasts

1995 • 113 citations

Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin

1997 • 112 citations

p80/85 Cortactin Associates with the Src SH2 Domain and Colocalizes with v-Src in Transformed Cells

1995 • 112 citations

Protein kinase C mu is located at the Golgi compartment.

1996 • 105 citations

Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-alpha phosphorothioate oligodeoxynucleotide.

1996 • 100 citations

Invadopodia promote proteolysis of a wide variety of extracellular matrix proteins

1994 • 99 citations

Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18

1997 • 97 citations

Integrin alpha 3 beta 1 participates in the phagocytosis of extracellular matrix molecules by human breast cancer cells.

1996 • 89 citations

Induction of carcinoma cell migration on vitronectin by NF-kappa B-dependent gene expression.

1995 • 83 citations

The Redistribution of Cortactin into Cell-Matrix Contact Sites in Human Carcinoma Cells with 11q13 Amplification Is Associated with Both Overexpression and Post-translational Modification

1997 • 68 citations

Protein Kinase C-dependent and -independent Pathways in the Growth Factor-induced Cytoskeletal Reorganization

1989 • 48 citations

Density-dependent induction of 92-kd type IV collagenase activity in cultures of A431 human epidermoid carcinoma cells.

1994 • 45 citations

Expression and tyrosine phosphorylation of EMS1 in human breast cancer cell lines

1996 • 40 citations

The Product of the EMS1 Gene, Amplified and Overexpressed in Human Carcinomas, is Homologous to a v-src Substrate and is Located in Cell-Substratum Contact Sites

1993 • 38 citations

Release of collagen type IV degrading activity from C6 astrocytoma cells and cell density

1996 • 19 citations

Effect of diacylglycerols on osteoclastic bone resorption

1996 • 17 citations

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