Molecular insights into cancer invasion: strategies for prevention and intervention.

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

On the Crawling of Animal Cells

1993 • 1,020 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons

1992 • 895 citations

Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation.

1974 • 775 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.

1993 • 704 citations

Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat.

1994 • 599 citations

Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

1989 • 594 citations

Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.

1992 • 577 citations

Phosphoinositides and Calcium as Regulators of Cellular Actin Assembly and Disassembly

1994 • 524 citations

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1994 • 523 citations

Loss of basement membrane components by invasive tumors but not by their benign counterparts.

1983 • 497 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 • 445 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

Life at the Leading Edge: The Formation of Cell Protrusions

1993 • 442 citations

Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases.

1992 • 429 citations

Progress against Cancer?

1986 • 420 citations

Role of the alpha v beta 3 integrin in human melanoma cell invasion.

1992 • 414 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation.

1994 • 363 citations

The Activation of Human Type IV Collagenase Proenzyme

1989 • 347 citations

Tumor Cell Invasion Inhibited by TIMP-2

1991 • 324 citations

Immunohistochemical distribution of type IV collagenase in normal, benign, and malignant breast tissue.

1990 • 323 citations

Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

1988 • 312 citations

Cancer Metastasis: Experimental Approaches, Theoretical Concepts, and Impacts for Treatment Strategies

1985 • 301 citations

v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines.

1993 • 291 citations

Angiogenesis: role of calcium-mediated signal transduction.

1995 • 283 citations

Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma.

1991 • 282 citations

Mechanisms of trophoblast invasiveness and their control: the role of proteases and protease inhibitors

1990 • 267 citations

Partial purification and characterization of a neutral protease which cleaves type IV collagen

1981 • 241 citations

Influence of Organ Environment on Extracellular Matrix Degradative Activity and Metastasis of Human Colon Carcinoma Cells

1990 • 238 citations

Primary Rat Embryo Cells Transformed by One or Two Oncogenes Show Different Metastatic Potentials

1986 • 196 citations

Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

1989 • 193 citations

Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo.

1994 • 189 citations

Ca2+ influx following receptor activation

1991 • 187 citations

Inositol phosphates and Ca ²⁺ entry: toward a proliferation or a simplification?

1992 • 184 citations

The study of mammary carcinoma by mammography and whole organ sectioningearly observations

1969 • 179 citations

Characterization of the procollagen IV cleavage products produced by a specific tumor collagenase.

1984 • 178 citations

An inhibitor of collagenase from human amniotic fluid. Purification, characterization and action on metalloproteinases

1981 • 171 citations

Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells.

1989 • 163 citations

Cytokine-induced pseudopodial protrusion is coupled to tumour cell migration

1987 • 147 citations

Protein Kinase C: A Novel Target for Inhibiting Gastric Cancer Cell Invasion

1993 • 142 citations

Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide.

1994 • 141 citations

Effect of Natural Protease Inhibitors and a Chemoattractant on Tumor Cell Invasion In Vitro

1982 • 141 citations

Cathepsin D: A protease involved in breast cancer metastasis

1990 • 140 citations

L651582: A Novel Antiproliferative and Antimetastasis Agent

1990 • 132 citations

Calcium influx modulates expression of matrix metalloproteinase-2 (72-kDa type IV collagenase, gelatinase A).

1994 • 132 citations

Identical allelic loss on chromosome 11q13 in microdissected in situ and invasive human breast cancer.

1995 • 128 citations

Progress in cancer chemoprevention: perspectives on agent selection and short-term clinical intervention trials.

1994 • 124 citations

Expression of Human Recombinant Plasminogen Activators Enhances Invasion and Experimental Metastasis of H-ras-Transformed NIH 3T3 Cells

1989 • 120 citations

In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates.

1992 • 116 citations

Regulated tyrosine phosphorylation at the tips of growth cone filopodia.

1993 • 110 citations

The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release.

1991 • 100 citations

Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI.

1994 • 99 citations

Prevention--therapy--basic science and the resolution of the cancer problem.

1993 • 93 citations

Management and survival of female patients with “minimal” breast cancer: As observed in the long-term and short-term surveys of the american college of surgeons

1981 • 90 citations

Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-gamma. An alternative mechanism for cholinergic-induced phosphoinositide breakdown.

1993 • 87 citations

Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment.

1992 • 86 citations

Cloning and characterization of human tumor cell interstitial collagenase.

1990 • 74 citations

Pathways of Ras Function: Connections to the Actin Cytoskeleton

1993 • 64 citations

Geometry, growth rates, and duration of cancer and carcinoma in situ of the breast before detection by screening.

1986 • 62 citations

Type IV collagen stimulates an increase in intracellular calcium. Potential role in tumor cell motility.

1992 • 57 citations

8 Synthetic Inhibitors of Bacterial and Mammalian Interstitial Collagenases

1992 • 55 citations

Gene expression, cellular diversification and tumor progression to the metastatic phenotype

1991 • 53 citations

Two Phases of Pseudopod Protrusion in Tumor Cells Revealed by a Micropipette

1994 • 46 citations

Potent peptide inhibitors of stromelysin based on the prodomain region of matrix metalloproteinases.

1994 • 36 citations

Tyrosine protein kinase activity of the EGF receptor is required to induce activation of receptor-operated calcium channels

1989 • 36 citations

Inhibition of retinal growth cone activity by specific metalloproteinase inhibitors in vitro

1994 • 35 citations

Reexpression of neu-encoded oncoprotein counteracts the tumor-suppressing but not the metastasis-suppressing function of E1A.

1993 • 33 citations

Drugs active against growth factor and oncogene phosphatidylinositol signalling pathways.

1992 • 9 citations

Negative growth selection against rodent fibroblasts targeted for genetic inhibition of farnesyl transferase.

1993 • 8 citations