Genes and Cellular Requirements for Autoimmune Diabetes Susceptibility in Nonobese Diabetic Mice

Biology of interleukin 1

1988 • 1,547 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Genetic Analysis of Autoimmune Disease

1996 • 739 citations

A Molecular Basis for MHC Class II—Associated Autoimmunity

1988 • 707 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

The NOD mouse model of type 1 diabetes: As good as it gets?

1999 • 592 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

1996 • 581 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

SELECTION OF THE T CELL REPERTOIRE

1999 • 507 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

1997 • 460 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Adoptive Transfer of Diabetes Into Immunodeficient NOD-scid/scid Mice: Relative Contributions of CD4+ and CD8+ T-Cells From Diabetic Versus Prediabetic NOD.NON-Thy-1a Donors

1993 • 431 citations

The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex

1986 • 424 citations

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.

1987 • 402 citations

Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans

1999 • 386 citations

Acceleration of Diabetes in Young Nod Mice with a CD4 ⁺ Islet-specific T Cell Clone

1990 • 385 citations

Immunoregulatory and Cytokine Imbalances in the Pathogenesis of IDDM: Therapeutic Intervention by Immunostimulation?

1994 • 363 citations

Early quantitative and functional deficiency of NK1⁺‐like thymocytes in the NOD mouse

1996 • 359 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

Spontaneous Autoimmune Diabetes in Monoclonal T Cell Nonobese Diabetic Mice

1997 • 359 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

1996 • 349 citations

Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain

1990 • 334 citations

Self-Nonself Discrimination by T Cells

1990 • 331 citations

CD28 costimulation promotes the production of Th2 cytokines.

1997 • 299 citations

Polygenic control of autoimmune diabetes in nonobese diabetic mice

1993 • 298 citations

Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1.

1997 • 291 citations

The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.

1992 • 274 citations

Association Between αβTCR+CD4−CD8− T-Cell Deficiency and IDDM in NOD/Lt Mice

1997 • 258 citations

A Structural Framework for Deciphering the Link Between I-A ^g7 and Autoimmune Diabetes

2000 • 256 citations

Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.

1993 • 254 citations

Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

1997 • 248 citations

Pancreatic islet-specific T-cell clones from nonobese diabetic mice.

1989 • 246 citations

Genetic Absence of γ-Interferon Delays but Does Not Prevent Diabetes in NOD Mice

1996 • 244 citations

I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice.

1999 • 228 citations

Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-alpha and IL-1 beta production by human monocytes.

1994 • 224 citations

Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer.

1992 • 224 citations

T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

1997 • 223 citations

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.

1996 • 217 citations

Prevention of diabetes in non-obese diabetic I-Ak transgenic mice

1990 • 204 citations

Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice

1990 • 203 citations

A Mechanism for the Major Histocompatibility Complex–linked Resistance to Autoimmunity

1997 • 202 citations

Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies.

1988 • 199 citations

Differential ability of T cell subsets to undergo activation-induced cell death

1997 • 188 citations

Immunostimulation circumvents diabetes in NODLt mice

1989 • 182 citations

On the pathogenesis of IDDM

1994 • 181 citations

Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese diabetic mice

1997 • 178 citations

Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes.

1992 • 178 citations

Prevention of type I diabetes in NOD mice by nonhypercalcemic doses of a new structural analog of 1,25-dihydroxyvitamin D3, KH1060.

1995 • 177 citations

Maternal Environment and Genotype Interact to Establish Diabesity in Mice

2000 • 176 citations

T-cell selection

1998 • 168 citations

The NOD Idd9 Genetic Interval Influences the Pathogenicity of Insulitis and Contains Molecular Variants of Cd30, Tnfr2, and Cd137

2000 • 163 citations

Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C.

1993 • 162 citations

GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.

1998 • 160 citations

Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice.

1994 • 157 citations

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

2000 • 157 citations

Identification of a CD8 T Cell That Can Independently Mediate Autoimmune Diabetes Development in the Complete Absence of CD4 T Cell Helper Functions

2000 • 148 citations

The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice.

1991 • 147 citations

Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.

1994 • 147 citations

Congenic Mapping of the Type 1 Diabetes Locus,Idd3, to a 780-kb Region of Mouse Chromosome 3: Identification of a Candidate Segment of Ancestral DNA by Haplotype Mapping

2000 • 140 citations

A Defect in Interleukin 12–Induced Activation and Interferon γ Secretion of Peripheral Natural Killer T Cells in Nonobese Diabetic Mice Suggests New Pathogenic Mechanisms for Insulin-Dependent Diabetes Mellitus

1999 • 136 citations

The genetics of diabetes susceptibility in mice

1989 • 134 citations

Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent.

1997 • 134 citations

Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death.

1992 • 120 citations

An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells.

1993 • 118 citations

Intrathymic Islet Cell Transplantation Reduces β-Cell Autoimmunity and Prevents Diabetes in NOD/Lt Mice

1992 • 118 citations

Antigen-specific B cells preferentially induce CD4+ T cells to produce IL-4.

1997 • 117 citations

Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse Chromosome 3

1998 • 116 citations

Transfer of Diabetes in the NOD-scid Mouse by CD4 T-Cell Clones: Differential Requirement for CD8 T-Cells

1996 • 115 citations

Autoimmune Diabetes in NOD Mouse Is L3T4 T-Lymphocyte Dependent

1987 • 115 citations

GENETIC CONTROL OF SURVIVAL IN EPIDEMICS

1979 • 114 citations

NOD mice have a generalized defect in their response to transplantation tolerance induction.

1999 • 114 citations

CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4.

1993 • 112 citations

Complement Lytic Activity Has No Role in the Pathogenesis of Autoimmune Diabetes in NOD Mice

1993 • 110 citations

Combined Treatment With Nicotinamide and Desferrioxamine Prevents Islet Allograft Destruction in NOD Mice

1986 • 110 citations

A gene telomeric of the HLA class I region is involved in predisposition to both type 1 diabetes and coeliac disease

1999 • 106 citations

Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin.

1998 • 104 citations

Low CD86 Expression in the Nonobese Diabetic Mouse Results in the Impairment of Both T Cell Activation and CTLA-4 Up-Regulation

2000 • 104 citations

Linkage on Chromosome 3 of Autoimmune Diabetes and Defective Fc Receptor for IgG in NOD mice

1993 • 103 citations

Analysis of the Spontaneous T Cell Response to Insulin in NOD Mice

1994 • 101 citations

Processing and Presentation of Endocytically Acquired Protein Antigens by MHC Class II and Class I Molecules

1996 • 99 citations

Protection of Nonobese Diabetic Mice from Diabetes by Gene(s) Closely Linked to IFN-γ Receptor Loci

2000 • 99 citations

Islet-Specific T-Cell Clones From the NOD Mouse Respond to β-Granule Antigen

1994 • 99 citations

Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping.

1995 • 98 citations

Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: An approach for the genetic dissection of complex traits

1996 • 97 citations

Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation.

1993 • 97 citations

Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.

1995 • 93 citations

Genetic Control of Diabetogenesis in NOD/Lt Mice: Development and Analysis of Congenic Stocks

1989 • 88 citations

Defective Fc gamma RII gene expression in macrophages of NOD mice: genetic linkage with up-regulation of IgG1 and IgG2b in serum.

1996 • 86 citations

Peripheral deletion of mature CD8+ antigen-specific T cells after in vivo exposure to male antigen.

1992 • 84 citations

Prevention of insulitis and diabetes in Β2-microglobulin-deficjent non-obese diabetic mice

1994 • 82 citations

Pancreatic Hormone Expression in the Murine Thymus: Localization in Dendritic Cells and Macrophages

1998 • 78 citations

Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait.

1999 • 76 citations

Presentation of beta-cell antigens to CD4+ and CD8+ T cells of non-obese diabetic mice.

1993 • 75 citations

The Role of Lymphocyte Subsets in Accelerated Diabetes in Nonobese Diabetic–Rat Insulin Promoter–B7-1 (NOD-RIP-B7-1) Mice

1998 • 74 citations

The NOD Mouse: A Model for Analyzing the Interplay Between Heredity and Environment in Development of Autoimmune Disease

1993 • 72 citations

Suggestive Evidence for Association of Human Chromosome 18q12-q21 and Its Orthologue on Rat and Mouse Chromosome 18 With Several Autoimmune Diseases

2001 • 69 citations

CD8 T Cells Are Not Required for Islet Destruction Induced by a CD4+ Islet-Specific T-Cell Clone

1992 • 69 citations

IL-7 reverses NK1⁺ Tcell-defective IL-4 production in the non-obese diabetic mouse

1996 • 69 citations

Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation.

1998 • 69 citations

Islet-Infiltrating Lymphocytes from Prediabetic NOD Mice Rapidly Transfer Diabetes to NOD-scid/scid mice

1995 • 68 citations

Lymphocyte lineage commitment: Instruction versus selection

1993 • 67 citations

Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines

1999 • 67 citations

Delineation of antigen contact residues on an MHC class II molecule.

1990 • 66 citations

Inhibition of Diabetes by an Insulin-Reactive CD4 T-Cell Clone in the Nonobese Diabetic Mouse

1997 • 66 citations

Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from multiple sclerosis patients and normal individuals.

1995 • 61 citations

Prevention of Diabetes in NOD Mice by Injection of Autoreactive T-Lymphocytes

1989 • 60 citations

Efficacy of exogenous recombinant murine leptin in lean and obese 10- to 12-mo-old female CD-1 mice

1998 • 60 citations

Genetic control of diabetes and insulitis in the nonobese diabetic mouse. Pedigree analysis of a diabetic H-2nod/b heterozygote.

1989 • 59 citations

Bone marrow abnormalities in the non-obese diabetic mouse

1993 • 58 citations

CD4+ beta islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice.

1995 • 57 citations

Development of diabetogenic T cells from NOD/Lt marrow is blocked when an allo-H-2 haplotype is expressed on cells of hemopoietic origin, but not on thymic epithelium.

1991 • 57 citations

Two Genetic Loci Regulate T Cell–Dependent Islet Inflammation and Drive Autoimmune Diabetes Pathogenesis

2000 • 57 citations

Regulation of human monocyte DNA synthesis by colony-stimulating factors, cytokines, and cyclic adenosine monophosphate

1992 • 56 citations

Autoantigen-Independent Deletion of Diabetogenic CD4+ Thymocytes by Protective MHC Class II Molecules

1999 • 54 citations

Analysis of peptide residues interacting with MHC molecule or T cell receptor. Can a peptide bind in more than one way to the same MHC molecule?

1990 • 51 citations

Failure of a protective major histocompatibility complex class II molecule to delete autoreactive T cells in autoimmune diabetes.

1993 • 49 citations

Evidence for the Presence of Insulin-Dependent Diabetes-Associated Alleles on the Distal Part of Mouse Chromosome 6

1998 • 49 citations

A Major Linkage Region on Distal Chromosome 4 Confers Susceptibility to Mouse Autoimmune Gastritis

1999 • 48 citations

Secretion of IL-1: role of protein kinase C.

1992 • 47 citations

Inheritance of susceptibility to experimental autoimmune encephalomyelitis

1996 • 47 citations

Multiple loci govern the bone marrow-derived immunoregulatory mechanism controlling dominant resistance to autoimmune orchitis.

1995 • 46 citations

Multiple TCR Vβ Usage by Infiltrates of Young NOD Mouse Islets of Langerhans: A Polymerase Chain Reaction Analysis

1992 • 45 citations

Genetics of Type 1 diabetes mellitus.

1999 • 45 citations

A diabetes-associated T-cell autoantigen maps to a telomeric locus on mouse chromosome 6.

1995 • 43 citations

Induction of Diabetes in Nonobese Diabetic Mice by Th2 T Cell Clones from a TCR Transgenic Mouse

2000 • 42 citations

Lilly Lecture 1986: Genes, Generator of Diversity, Glycoconjugates, and Autoimmune β-Cell Insufficiency in Type I Diabetes

1987 • 41 citations

T-Lymphocyte–Receptor Repertoire of Infiltrating T Lymphocytes Into NOD Mouse Pancreas

1991 • 41 citations

Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells.

1998 • 40 citations

Autoreactive Diabetogenic T-Cells in NOD Mice Can Efficiently Expand From a Greatly Reduced Precursor Pool

2001 • 40 citations

Complete characterization of the expressed immune response genes in Biozzi AB/H mice: structural and functional identity between AB/H and NOD A region molecules

1993 • 38 citations

Two Mechanisms for the Non-MHC-Linked Resistance to Spontaneous Autoimmunity

1999 • 35 citations

Localization of Idd11 using NOD congenic mouse strains: elimination of Slc9a1 as a candidate gene

2000 • 34 citations

Role of Inflammatory Infiltrate in Activation and Effector Function of Cloned Islet Reactive Nonobese Diabetic CD8+ T Cells: Involvement of a Nitric Oxide-Dependent Pathway

1999 • 33 citations

Derivation of Diabetes-Resistant Congenic Lines from the Nonobese Diabetic Mouse

2000 • 32 citations

Reevaluation of the major histocompatibility complex genes of the NOD-progenitor CTS/Shi strain.

2000 • 32 citations

MHC-Linked Diabetogenic Gene of the NOD Mouse: Molecular Mapping of the 3′ Boundary of the Diabetogenic Region

1993 • 27 citations

Potential Autoantigens In IDDM: Expression of Carboxypeptidase-H and Insulin But Not Glutamate Decarboxylase on the β-Cell Surface

1994 • 27 citations

Expression of the IL-1 receptor discriminates Th2 from Th1 cloned CD4+ T cells specific for Plasmodium chabaudi.

1994 • 24 citations

The Role of Environmental Factors in Modulating Insulin Dependent Diabetes

1990 • 23 citations

Suppression of diabetes mellitus in the non-obese diabetic (NOD) mouse by an autoreactive (anti-I-Ag7) islet-derived CD4+ T-cell line

1993 • 22 citations

In vivo activity of an islet-reactive T-cell clone

1990 • 22 citations

Analysis of Leukocytes Recruited to the Pancreas by Diabetogenic T Cell Clones

1998 • 20 citations

Functional analysis of cloned macrophage hybridomas. VII. Modulation of suppressor T cell-inducing activity.

1989 • 20 citations

MHC characterization of ALR and ALS mice: respective similarities to the NOD and NON strains

1999 • 17 citations

HLA and infectious diseases

1979 • 15 citations

Lymph Node T-Cells Do Not Optimally Transfer Diabetes in NOD Mice

1993 • 12 citations

Congenic mapping and functional analysis of a second component of the MHC-linked diabetogenic gene (Idd16)

2000 • 8 citations