The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex

Breeding of a Non-Obese, Diabetic Strain of Mice

1980 • 1,255 citations

Histocompatibility-Linked Immune Response Genes

1972 • 1,194 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.

1981 • 531 citations

HLA-linked congenital adrenal hyperplasia results from a defective gene encoding a cytochrome P-450 specific for steroid 21-hydroxylation.

1984 • 291 citations

New Lymphocyte Antigen System ( Lna ) Controlled by the Ir Region of the Mouse H-2 Complex

1973 • 282 citations

Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.

1983 • 245 citations

Isolation of twelve monoclonal antibodies against Ia and H-2 antigens. Serological characterization and reactivity with B and T lymphocytes

1979 • 193 citations

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells.

1984 • 190 citations

RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex.

1983 • 145 citations

Murine I-Aβ Chain Polymorphism: Nucleotide Sequences of Three Allelic I-Aβ Genes

1983 • 139 citations

Production of autoreactive I region-restricted T cell hybridomas.

1982 • 122 citations

The complete nucleotide sequence of the I-Eα^dimmune response gene

1983 • 90 citations

Can Future Type I Diabetes Be Predicted? A Study in Families of Affected Children

1982 • 87 citations

Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses.

1984 • 78 citations

Genetic control of specific immune suppression. III. Mapping of H-2 complex complementing genes controlling immune suppression by the random copolymer L-glutamic acid(50)-L-Tyrosine(50) (GT)

1976 • 56 citations

Genetic Analysis for Insulitis in NOD Mice

1985 • 56 citations

Interaction between I region loci influences the expression of a cell surface Ia antigen.

1980 • 55 citations

Major histocompatibility complex restriction fragment length polymorphisms define three diabetogenic haplotypes in BB and BBN rats.

1985 • 14 citations

Specific Class II Histocompatibility Gene Polymorphism in BB Rats

1984 • 10 citations