A Molecular Basis for MHC Class II—Associated Autoimmunity

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes

1986 • 1,863 citations

The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells

1987 • 1,040 citations

Molecular mimicry and autoimmune disease

1987 • 943 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 942 citations

The class II molecules of the human and murine major histocompatibility complex

1984 • 664 citations

The T Cell Receptor

1987 • 554 citations

HLA and Disease 1982 ‐ A Survey

1983 • 551 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex

1986 • 424 citations

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.

1987 • 402 citations

In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon.

1987 • 396 citations

Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility.

1988 • 378 citations

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

1987 • 367 citations

DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

1985 • 340 citations

Three Recessive Loci Required for Insulin-Dependent Diabetes in Nonobese Diabetic Mice

1987 • 293 citations

Polymorphism of human Ia antigens: gene conversion between two DR β loci results in a new HLA-D/DR specificity

1986 • 292 citations

HLA-D region β-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals

1983 • 265 citations

Immunological self/nonself discrimination

1999 • 265 citations

Immunology of Insulin-Dependent Diabetes Mellitus

1985 • 240 citations

Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis.

1987 • 237 citations

A Newly Characterized HLA DQ _β Allele Associated with Pemphigus Vulgaris

1988 • 230 citations

In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.

1981 • 228 citations

Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse.

1987 • 222 citations

Allelic variation in the DR subregion of the human major histocompatibility complex.

1987 • 220 citations

HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans

1987 • 212 citations

HLA class II allelic variation and susceptibility to pemphigus vulgaris.

1988 • 211 citations

Regions of allelic hypervariability in the murine Aα immune response gene

1983 • 185 citations

Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis

1986 • 184 citations

Nucleotide sequence of mutant I-Aβbm12 gene is evidence for genetic exchange between mouse immune response genes

1984 • 178 citations

Correcting an immune-response deficiency by creating Eα gene transgenic mice

1985 • 171 citations

Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis.

1987 • 163 citations

Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene.

1983 • 162 citations

Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: studies of the HLA class II loci.

1985 • 160 citations

The molecular basis for HLA class II associations with rheumatoid arthritis

1987 • 142 citations

New HLA DNA polymorphisms associated with autoimmune diseases

1986 • 135 citations

A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus.

1985 • 134 citations

Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene.

1985 • 133 citations

The nucleotide sequence of the murine I-E beta b immune response gene: evidence for gene conversion events in class II genes of the major histocompatibility complex.

1984 • 131 citations

Gene conversion between murine class II major histocompatibility complex loci. Functional and molecular evidence from the bm 12 mutant.

1984 • 126 citations

Measuring the genetic contribution of a single locus to a multilocus disease

1984 • 108 citations

Detection of disease-specific restriction fragment length polymorphisms in pemphigus vulgaris linked to the DQw1 and DQw3 alleles of the HLA-D region.

1987 • 107 citations

Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I-A beta cDNA clones.

1986 • 105 citations

Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.

1987 • 103 citations

Only one DQ-beta restriction fragment pattern of each DR specificity is associated with insulin-dependent diabetes.

1986 • 100 citations

Analysis of the Expression and Function of Class-II Major Histocompatibility Complex-Encoded Molecules by DNA-Mediated Gene Transfer

1986 • 96 citations

Functionally distinct subsites on a class II major histocompatibility complex molecule

1987 • 95 citations

HLA-DO polymorphism associated with resistance to type I diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction fragment length polymorphism.

1986 • 87 citations

A molecular basis for genetic susceptibility to insulin-dependent diabetes mellitus

1988 • 86 citations

Polymorphism of HLA-DR beta chains in DR4, -7, and -9 haplotypes: implications for the mechanisms of allelic variation.

1986 • 79 citations

Serological and cellular definition of a new HLA-DR associated determinant, MC1, and its association with rheumatoid arthritis

1984 • 75 citations

High-affinity fluorescent peptide binding to I-Ad in lipid membranes.

1986 • 73 citations

Shared T cell recognition sites on human histocompatibility leukocyte antigen class II molecules of patients with seropositive rheumatoid arthritis.

1986 • 72 citations

Polymorphism of the HLA-D region in American blacks. A DR3 haplotype generated by recombination.

1988 • 70 citations

Nucleotide sequence of an HLA-DQ alpha chain derived from a DRw9 cell line: genetic and evolutionary implications.

1985 • 62 citations

Structural and functional variability among DQ ? alleles of DR2 subtypes

1987 • 56 citations

Nucleotide sequence of a DRw10 beta chain cDNA clone. Identity of the third D region with that of the DRw53 allele of the beta 2 locus and as the probable site encoding a polymorphic MHC class II epitope.

1988 • 55 citations

Genetics of rheumatoid arthritis

1986 • 47 citations

Autologous mixed lymphocyte reaction in man: XV. Cellular and molecular basis of deficient autologous mixed lymphocyte response in insulin-dependent diabetes mellitus

1984 • 40 citations

Relation of insulin‐dependent diabetes mellitus (IDD) and the HLA‐linked SB system

1984 • 36 citations

Structural relationships between the DR beta 1 and DR beta 2 subunits in DR4, 7, and w9 haplotypes and the DRw53 (MT3) specificity.

1986 • 36 citations

HLA-DQw3.2 allele of the DR4 haplotype is associated with insulin-dependent diabetes; correlation between DQ ? restriction fragments and DQ ? chain variation

1987 • 35 citations

THE LYMPHOCYTE IN NATURAL AND INDUCED RESISTANCE TO TRANSPLANTED CANCER

1918 • 35 citations

Is predisposition to pemphigus vulgaris in Jewish patients mediated by HLA‐Dw10 and DR4?

1984 • 25 citations

Cellular typing and functional heterogeneity of MHC-encoded products

1987 • 18 citations