Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin.

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

1996 • 581 citations

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.

1987 • 402 citations

Lessons from Animal Diabetes

1984 • 358 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain

1990 • 334 citations

Major Histocompatibility Complex Class I-Deficient NOD-B2mnull Mice are Diabetes and Insulitis Resistant

1994 • 301 citations

Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.

1993 • 254 citations

β2-Microglobulin–Deficient NOD Mice Do Not Develop Insulitis or Diabetes

1994 • 241 citations

Structure of wild-type and mutant mouse β2-microglobulin genes

1982 • 230 citations

Linkage of Faulty Major Histocompatibility Complex Class I to Autoimmune Diabetes

1991 • 212 citations

Prevention of diabetes in non-obese diabetic I-Ak transgenic mice

1990 • 204 citations

Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice

1990 • 203 citations

Major histocompatibility complex class I molecules are required for the development of insulitis in non‐obese diabetic mice

1993 • 201 citations

Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies.

1988 • 199 citations

On the pathogenesis of IDDM

1994 • 181 citations

Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C.

1993 • 162 citations

NOR/Lt Mice: MHC-Matched Diabetes-Resistant Control Strain for NOD Mice

1992 • 151 citations

Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.

1994 • 147 citations

Crosses of NOD Mice With the Related NON Strain: A Polygenic Model for IDDM

1995 • 140 citations

Genetic and pathogenic basis of autoimmune diabetes in NOD mice

1994 • 136 citations

Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent.

1997 • 134 citations

Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.

1997 • 129 citations

An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells.

1993 • 118 citations

A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population

1994 • 101 citations

Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping.

1995 • 98 citations

Self peptides isolated from MHC glycoproteins of non-obese diabetic mice.

1994 • 92 citations

NOD Marrow Stem Cells Adoptively Transfer Diabetes to Resistant (NOD × NON)F1 Mice

1988 • 87 citations

Prevention of insulitis and diabetes in Β2-microglobulin-deficjent non-obese diabetic mice

1994 • 82 citations

Expression of genetically determined diabetes and insulitis in the nonobese diabetic (NOD) mouse at the level of bone marrow-derived cells. Transfer of diabetes and insulitis to nondiabetic (NOD X B10) F1 mice with bone marrow cells from NOD mice.

1988 • 82 citations

Genomic analysis of the C57BL/Ks mouse strain

1995 • 66 citations

β2-Microglobulin restriction of antigen presentation

1990 • 66 citations

Development of diabetogenic T cells from NOD/Lt marrow is blocked when an allo-H-2 haplotype is expressed on cells of hemopoietic origin, but not on thymic epithelium.

1991 • 57 citations

A new marker in the HLA class I region is associated with the age at onset of IDDM

1995 • 50 citations

Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides.

1994 • 43 citations

Protection against autoimmune diabetes in mixed bone marrow chimeras: mechanisms involved.

1997 • 37 citations

Polymorphism in the mouse Tap-1 gene. Association with abnormal CD8+ T cell development in the nonobese nondiabetic mouse.

1993 • 35 citations

Altered structure of HLA class I heavy chains associated with mouse beta-2 microglobulin

1985 • 33 citations

Abnormal class I assembly and peptide presentation in the nonobese diabetic mouse.

1994 • 27 citations

Expression of glycogen synthase and phosphofructokinase in muscle from Type 1 (insulin-dependent) diabetic patients before and after intensive insulin treatment

1994 • 26 citations

The association of H-2Ld with human beta-2 microglobulin induces localized conformational changes in the alpha-1 and- 2 superdomain

1989 • 26 citations

MHC Class I-Mediated Antigen Presentation and Induction of CD8+ Cytotoxic T-Cell Responses in Autoimmune Diabetes-Prone NOD Mice

1996 • 24 citations

Transplantation analysis of B cell destruction in (NOD x CBA)F1 mouse bone marrow chimeras

1990 • 21 citations

Beta 2-microglobulin induces a conformational change in an MHC class I H chain that occurs intracellularly and is maintained at the cell surface.

1994 • 18 citations

Levels of Tap-1 and Tap-2 mRNA and Expression of Kd and Db on Splenic Lymphocytes Are Normal in NOD Mice

1995 • 8 citations

Elimination of Self-Peptide Major Histocompatibility Complex Class I Reactivity in NOD and β2-Microglobulin-Negative Mice

1995 • 7 citations