The role of protein kinase C in the development of the complications of diabetes

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

1998 • 19,638 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

1998 • 7,971 citations

Diabetic Retinopathy

1974 • 5,744 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

1994 • 4,626 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

1994 • 3,652 citations

Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study

1995 • 3,109 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Vitamin E Consumption and the Risk of Coronary Heart Disease in Men

1993 • 2,363 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

Vitamin E Consumption and the Risk of Coronary Disease in Women

1993 • 2,158 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Oxidative Stress and Diabetic Vascular Complications

1996 • 1,947 citations

Grading Diabetic Retinopathy from Stereoscopic Color Fundus Photographs—An Extension of the Modified Airlie House Classification

1991 • 1,822 citations

Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis

1991 • 1,703 citations

Predicting Diabetic Nephropathy in Insulin-Dependent Patients

1984 • 1,603 citations

The extended protein kinase C superfamily

1998 • 1,544 citations

Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis

1999 • 1,494 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population‐based cohort

1993 • 1,410 citations

Antioxidants and Atherosclerotic Heart Disease

1997 • 1,390 citations

Flow-induced release of endothelium-derived relaxing factor

1986 • 1,379 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension.

1986 • 1,210 citations

Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1993 • 1,102 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus

1996 • 1,024 citations

Protein kinase recognition sequence motifs

1990 • 1,014 citations

Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1992 • 922 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

1990 • 871 citations

Hypothesis: Vasa Vasorum and Neovascularization of Human Coronary Arteries

1984 • 852 citations

Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.

1993 • 819 citations

The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies

1982 • 807 citations

Role of oxidative stress in development of complications in diabetes

1991 • 787 citations

Glomerular hemodynamics in experimental diabetes mellitus

1981 • 785 citations

Activation of Receptor for Advanced Glycation End Products

1999 • 775 citations

The Sorbitol Pathway and the Complications of Diabetes

1973 • 750 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

NITRIC OXIDE SYNTHASE: Role in the Genesis of Vascular Disease

1997 • 719 citations

Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.

1994 • 702 citations

Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.

1992 • 697 citations

Angiogenesis Inhibitors Endostatin or TNP-470 Reduce Intimal Neovascularization and Plaque Growth in Apolipoprotein E–Deficient Mice

1999 • 690 citations

Hyperglycemia rapidly suppresses flow-mediated endothelium- dependent vasodilation of brachial artery

1999 • 678 citations

Vascular Endothelial Growth Factor–Induced Retinal Permeability Is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform–Selective Inhibitor

1997 • 665 citations

A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines.

1986 • 641 citations

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

1992 • 621 citations

High Blood Glucose Concentration Is a Risk Factor for Mortality in Middle-Aged Nondiabetic Men: 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study

1998 • 612 citations

Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta.

1994 • 593 citations

The Effect of Intensive Diabetes Therapy on the Development and Progression of Neuropathy

1995 • 577 citations

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.

1996 • 567 citations

Free radicals mediate endothelial cell dysfunction caused by elevated glucose

1992 • 566 citations

Predominance of hemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy.

1985 • 532 citations

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

1997 • 532 citations

Treatment Techniques and Clinical Guidelines for Photocoagulation of Diabetic Macular Edema

1987 • 527 citations

Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.

1993 • 521 citations

Identification of intracellular receptor proteins for activated protein kinase C.

1991 • 505 citations

PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH.

1986 • 489 citations

Diabetic Retinopathy

1998 • 484 citations

Regulation of vascular endothelial barrier function

1994 • 481 citations

Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes.

1999 • 466 citations

Glycosylated Hemoglobin and the Risk of Microalbuminuria in Patients with Insulin-Dependent Diabetes Mellitus

1995 • 460 citations

Progression of Incipient Diabetic Retinopathy During Good Glycemic Control

1987 • 453 citations

The Prospective Cardiovascular Münster (PROCAM) study: Prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease

1988 • 445 citations

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

1994 • 444 citations

Impairment of Coronary Vascular Reserve and ACh-Induced Coronary Vasodilation in Diabetic Patients With Angiographically Normal Coronary Arteries and Normal Left Ventricular Systolic Function

1993 • 443 citations

Tissue and cellular distribution of the extended family of protein kinase C isoenzymes

1992 • 441 citations

The Human Preproendothelin-1 Gene

1989 • 441 citations

The Roles of Oxidative Stress and Antioxidant Treatment in Experimental Diabetic Neuropathy

1997 • 436 citations

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

1991 • 429 citations

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

2000 • 425 citations

Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries.

1988 • 422 citations

Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels

1996 • 416 citations

Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain.

1994 • 406 citations

Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle

1986 • 380 citations

Lipoic Acid Improves Nerve Blood Flow, Reduces Oxidative Stress, and Improves Distal Nerve Conduction in Experimental Diabetic Neuropathy

1995 • 377 citations

Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta.

1990 • 375 citations

Angiogenesis and the atherosclerotic carotid plaque: An association between symptomatology and plaque morphology

1999 • 354 citations

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats

1986 • 350 citations

Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery.

1982 • 345 citations

A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.

1992 • 340 citations

(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and Related Analogues: Isozyme Selective Inhibitors of Protein Kinase Cβ

1996 • 336 citations

High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes.

1999 • 326 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.

1991 • 316 citations

Hemodynamic factors in the genesis of diabetic microangiopathy

1983 • 314 citations

Metabolic and Vascular Factors in the Pathogenesis of Diabetic Neuropathy

1997 • 314 citations

Renal cytochrome P450-related arachidonate metabolite inhibits (Na+ + K+)ATPase

1985 • 314 citations

Short and long term effects of antihypertensive therapy in the diabetic rat

1989 • 310 citations

α-Tocopherol Inhibits Aggregation of Human Platelets by a Protein Kinase C–Dependent Mechanism

1996 • 309 citations

Bipartite Ca ²⁺ -Binding Motif in C ₂ Domains of Synaptotagmin and Protein Kinase C

1996 • 307 citations

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation

1993 • 306 citations

Hyperglycemic pseudohypoxia and diabetic complications

1993 • 305 citations

Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy.

1996 • 302 citations

Pathogenesis of diabetic neuropathy

1986 • 301 citations

Vascular Endothelial Growth Factor in Ocular Neovascularization and Proliferative Diabetic Retinopathy

1997 • 301 citations

Fiber loss is primary and multifocal in sural nerves in diabetic polyneuropathy

1986 • 297 citations

Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes

1993 • 290 citations

Microangiopathy in human diabetic neuropathy: relationship between capillary abnormalities and the severity of neuropathy

1989 • 286 citations

Effect of intensive diabetes treatment on nerve conduction in the diabetes control and complications trial

1995 • 282 citations

Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus

1997 • 282 citations

Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules

1998 • 279 citations

The pathogenesis of a coronary thrombus.

1966 • 277 citations

Glucose-Induced Protein Kinase C Activation Regulates Vascular Permeability Factor mRNA Expression and Peptide Production by Human Vascular Smooth Muscle Cells In Vitro

1997 • 276 citations

Banting Lecture 1986: Does a Common Mechanism Induce the Diverse Complications of Diabetes?

1987 • 275 citations

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

1988 • 275 citations

Enhanced Expression of Vascular Matrix Metalloproteinases Induced In Vitro by Cytokines and in Regions of Human Atherosclerotic Lesions^a

1994 • 272 citations

Increased endothelial albumin permeability mediated by protein kinase C activation.

1990 • 271 citations

Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction.

1988 • 270 citations

The epidemiology of cardiovascular disease in type 2 diabetes mellitus: how sweet it is … or is it?

1997 • 269 citations

DISFUNCTION OF VASCULAR ENDOTHELIUM IN DIABETES MELLITUS

1993 • 259 citations

Sural nerve oxygen tension in diabetes.

1986 • 258 citations

The Extracellular Matrix in Diabetic Nephropathy

1993 • 256 citations

Intravitreal Sustained Release of VEGF Causes Retinal Neovascularization in Rabbits and Breakdown of the Blood– Retinal Barrier in Rabbits and Primates

1997 • 251 citations

The spatial distribution of fiber loss in diabetic polyneuropathy suggests ischemia

1986 • 250 citations

Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats

1994 • 244 citations

Arachidonic Acid Metabolism: Implications of Biological Chemistry for Lung Function and Disease

1991 • 240 citations

Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy

1999 • 239 citations

Expression of transforming growth factor-β1 during diabetic renal hypertrophy

1994 • 237 citations

Acute Amelioration of Diabetic Endothelial Dysfunction with a Derivative of the Nitric Oxide Synthase Cofactor, Tetrahydrobiopterin

1997 • 224 citations

A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.

1999 • 223 citations

Increase in Diacylglycerol Mass in Isolated Glomeruli by Glucose From De Novo Synthesis of Glycerolipids

1990 • 219 citations

Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol.

1997 • 218 citations

Diabetic Neuropathy—New Concepts of Its Etiology

1979 • 218 citations

Capillary number and percentage closed in human diabetic sural nerve.

1985 • 216 citations

Shear stress increases inositol trisphosphate levels in human endothelial cells

1990 • 215 citations

Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart.

1991 • 212 citations

Nerve Blood Flow and Oxygen Delivery In Normal, Diabetic, and Ischemic Neuropathy

1989 • 212 citations

α-Tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity

1991 • 209 citations

Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation.

1996 • 203 citations

Mechanical forces and their second messengers in stimulating cell growth in vitro

1992 • 201 citations

Vascular factors in diabetic neuropathy

1994 • 199 citations

Altered Retinal Vascular Response to 100% Oxygen Breathing in Diabetes Mellitus

1984 • 194 citations

Phosphorylation of Protein Kinase C-α on Serine 657 Controls the Accumulation of Active Enzyme and Contributes to Its Phosphatase-resistant State

1997 • 194 citations

Untitled

1998 • 194 citations

The wisconsin epidemiological study of diabetic retinopathy: A review

1989 • 193 citations

Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.

1991 • 191 citations

Inhibition of Endothelial Nitric Oxide Synthase Activity by Protein Kinase C

1995 • 188 citations

Activation of the second promoter of the transforming growth factor-β1 gene by transforming growth factor-β1 and phorbol ester occurs through the same target sequences

1989 • 185 citations

Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor

1997 • 184 citations

Abnormalities of endoneurial microvessels and sural nerve pathology in diabetic neuropathy

1987 • 183 citations

The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment

1986 • 183 citations

Quantification of glomerular TGF-β1 mRNA in patients with diabetes mellitus

1996 • 182 citations

The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoprotein

1992 • 179 citations

Mechanism of impaired responses of cerebral arterioles during diabetes mellitus

1991 • 179 citations

Renal function in streptozotocin-diabetic rats

1981 • 178 citations

Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2.

1995 • 175 citations

Impairment of endothelium-dependent dilatation of cerebral arterioles during diabetes mellitus

1989 • 174 citations

Glomerular filtration surface in type I diabetes mellitus

1986 • 174 citations

Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus.

1985 • 171 citations

Normalization of Diacylglycerol-Protein Kinase C Activation by Vitamin E in Aorta of Diabetic Rats and Cultured Rat Smooth Muscle Cells Exposed to Elevated Glucose Levels

1994 • 170 citations

Impaired blood flow and arterio-venous shunting in human diabetic neuropathy: a novel technique of nerve photography and fluorescein angiography

1993 • 169 citations

Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKCbeta inhibition with LY333531.

1998 • 167 citations

Sequential alterations in glomerular prostaglandin and thromboxane synthesis in diabetic rats: Relationship to the hyperfiltration of early diabetes

1987 • 163 citations

Protein kinase C phosphorylates caldesmon₇₇ and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1992 • 163 citations

Oxygen Free Radical Effects in Sciatic Nerve in Experimental Diabetes

1991 • 161 citations

Neovascularization in atherectomy specimens from patients with unstable angina: Implications for pathogenesis of unstable angina

1998 • 159 citations

Extending the C2 domain family: C2s in PKCs δ, ϵ,η,θ, phospholipases, GAPs, and perforin

1996 • 158 citations

Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway

1995 • 158 citations

Endoneurial localisation of microvascular damage in human diabetic neuropathy

1993 • 155 citations

Regulation of Endothelial Constitutive Nitric Oxide Synthase by Protein Kinase C

1995 • 154 citations

Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols

1989 • 154 citations

Mutagenesis of the pseudosubstrate site of protein kinase C leads to activation

1990 • 144 citations

Peripheral nerves in early experimental diabetes

1978 • 143 citations

Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells.

1993 • 141 citations

Lysophosphatidylcholine increases vascular superoxide anion production via protein kinase C activation.

1994 • 139 citations

The impact of experimental diabetes mellitus in rats on glomerular capillary number and sizes

1993 • 138 citations

Nifedipine versus fosinopril in uninephrectomized diabetic rats

1992 • 136 citations

Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells

1997 • 135 citations

Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C.

1992 • 135 citations

Protein kinase C effects on nerve function, perfusion, Na + ,K + -ATPase activity and glutathione content in diabetic rats

1999 • 130 citations

Cellular and Molecular Abnormalities in the Vascular Endothelium of Diabetes Mellitus

1994 • 129 citations

A carbon-centered free radical intermediate in the prostaglandin synthetase oxidation of arachidonic acid. Spin trapping and oxygen uptake studies.

1980 • 128 citations

Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response.

1994 • 128 citations

Mechanical stretch induces vascular permeability factor in human mesangial cells: Mechanisms of signal transduction

1997 • 125 citations

Metabolic Control and Prevalent Cardiovascular Disease in Non-Insulin-dependent Diabetes Mellitus (NIDDM): The NIDDM Patient Outcomes Research Team

1997 • 125 citations

Lysophosphatidylcholine in oxidized low-density lipoprotein increases endothelial susceptibility to polymorphonuclear leukocyte-induced endothelial dysfunction in porcine coronary arteries. Role of protein kinase C.

1994 • 123 citations

Prevention of some electrophysiologic and biochemical abnormalities with oxygen supplementation in experimental diabetic neuropathy.

1984 • 122 citations

Activation of protein kinase C pathway contributes to hydrogen peroxide-induced increase in endothelial permeability.

1992 • 122 citations

Potential Therapeutic Approaches to the Treatment or Prevention of Diabetic Neuropathy: Evidence from Experimental Studies

1993 • 121 citations

Enhanced Expression of Inducible Nitric Oxide Synthase in Murine Macrophages and Glomerular Mesangial Cells by Elevated Glucose Levels: Possible Mediation via Protein Kinase C

1995 • 120 citations

Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in naive and streptozotocin-induced diabetic rats.

1989 • 118 citations

Differential localization of protein kinase C isozymes in U937 cells: evidence for distinct isozyme functions during monocyte differentiation

1995 • 117 citations

Vascular endothelial growth factor expression in peripheral nerves and dorsal root ganglia in diabetic neuropathy in rats

1999 • 116 citations

Autocrine secretion of transforming growth factor-β in cultured rat mesangial cells

1992 • 116 citations

Studies in the diabetic mutant mouse. VI. Evolution of glomerular lesions and associated proteinuria.

1972 • 111 citations

Neovascularization in early atherosclerotic lesions of human carotid arteries: Its potential contribution to plaque development

1999 • 110 citations

Responses of Cardiac Protein Kinase C Isoforms to Distinct Pathological Stimuli Are Differentially Regulated

1999 • 109 citations

Hydroperoxide-Induced Diacylglycerol Formation and Protein Kinase C Activation in Vascular Endothelial Cells

1993 • 109 citations

Protein Kinase C Agonists Acutely Normalize Decreased Ouabain-inhibitable Respiration in Diabetic Rabbit Nerve: Implications for (Na,K)-ATPase Regulation and Diabetic Complications

1986 • 109 citations

A strong correlation between glomerular filtration rate and filtration surface in diabetic nephropathy

1988 • 107 citations

Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases.

1998 • 106 citations

Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia

1994 • 106 citations

Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function

1993 • 104 citations

Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy

1995 • 103 citations

Calcium dependency of prostaglandin E2 production in rat glomerular mesangial cells. Evidence that protein kinase C modulates the Ca2+-dependent activation of phospholipase A2.

1988 • 103 citations

Altered retinal metabolism in diabetes. II. Measurement of sodium-potassium ATPase and total sodium and potassium in individual retinal layers.

1986 • 102 citations

Nitric oxide synthases: biochemical and molecular regulation

1995 • 101 citations

High glucose induces alteration of gap junction permeability and phosphorylation of connexin-43 in cultured aortic smooth muscle cells.

1998 • 100 citations

Exogenous oxidants initiate hydrolysis of endothelial cell inositol phospholipids

1988 • 100 citations

Progression of incipient diabetic retinopathy during good glycemic control

1987 • 99 citations

Is arachidonic acid a second messenger in signal transduction?

1991 • 98 citations

Hepatocyte Growth Factor in Vitreous Fluid of Patients With Proliferative Diabetic Retinopathy and Other Retinal Disorders

1998 • 97 citations

Effects of indomethacin on glomerular hemodynamics in experimental diabetes

1986 • 93 citations

Protein kinase C β1 overexpression augments phorbol ester-induced increase in endothelial permeability

1996 • 93 citations

Galactose neuropathy: Impact of chronic endoneurial edema on nerve blood flow

1984 • 89 citations

Diabetic Polyneuropathy: The Importance of Insulin Deficiency, Hyperglycemia and Alterations in Myoinositol Metabolism in Its Pathogenesis

1976 • 88 citations

Lysophosphatidylcholine stimulates the expression and production of MCP-1 by human vascular endothelial cells

1996 • 87 citations

Small vessel disease in progressive diabetic neuropathy associated with good metabolic control.

1985 • 85 citations

Transforming Growth Factor-β1 Enhances Glomerular Collagen Synthesis in Diabetic Rats

1993 • 85 citations

19(S)-hydroxyeicosatetraenoic acid is a potent stimulator of renal Na+-K+-ATPase

1988 • 84 citations

Relationship of Endoneurial Capillary Abnormalities to Type and Severity of Diabetic Polyneuropathy

1990 • 82 citations

Adenylate cyclase and protein kinase C mediate opposite actions on endothelial junctions

1990 • 81 citations

Protein kinase C in cyclic stretch-induced nerve growth factor production by urinary tract smooth muscle cells

1995 • 80 citations

Lipid abnormalities in tissues of the KKAy mouse: effects of pioglitazone on malonyl-CoA and diacylglycerol

1994 • 79 citations

The effects of insulin, glucose and diabetes on prostaglandin production by rat kidney glomeruli and cultured glomerular mesangial cells

1983 • 79 citations

Protein kinase C inhibitors prevent impairment of endothelium-dependent relaxation by oxidatively modified LDL.

1993 • 77 citations

Impairment of Endothelium-Dependent Relaxation by Increasing Percentages of Glycosylated Human Hemoglobin

1996 • 77 citations

Three-dimensional analysis of increased vasculature around the glomerular vascular pole in diabetic nephropathy

1993 • 74 citations

Protein kinase C-activated oxidant generation in endothelial cells signals intercellular adhesion molecule-1 gene transcription.

1999 • 72 citations

Reduced Glomerular Sodium/Potassium Adenosine Triphosphatase Activity in Acute Streptozocin Diabetes and Its Prevention by Oral Sorbinil

1985 • 71 citations

Protein kinase C and phospholipase C: bilayer interactions and regulation

1997 • 70 citations

Protein kinase C isozyme expression in sciatic nerves and spinal cords of experimentally diabetic rats

1997 • 69 citations

Ca2+-independent protein kinase Cs contain an amino-terminal domain similar to the C2 consensus sequence

1993 • 68 citations

Evolution of renal function abnormalities in the db/db mouse that parallels the development of human diabetic nephropathy.

1996 • 67 citations

Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle

1993 • 65 citations

Diminished Specific Activity of Cytosolic Protein Kinase C In Sciatic Nerve of Streptozocin-Induced Diabetic Rats and Its Correction by Dietary myo-Inositol

1991 • 64 citations

Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets

1994 • 62 citations

Oxygen free radical effects in sciatic nerve in experimental diabetes

1991 • 61 citations

Effects of a variety of cytokines and inducing agents on vascular permeability factor mRNA levels in U937 cells

1991 • 61 citations

Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro

1997 • 61 citations

α, βI, βII, δ, and ε Protein Kinase C Isoforms and Compound Activity in the Sciatic Nerve of Normal and Diabetic Rats

1994 • 60 citations

Role of Enhanced Arachidonate Availability Through Phospholipase A2 Pathway in Mediation of Increased Prostaglandin Synthesis by Glomeruli From Diabetic Rats

1988 • 58 citations

Prostaglandin E2 inhibits Na+-K+-ATPase activity in the inner medullary collecting duct

1989 • 55 citations

Normal blood flow but lower oxygen tension in diabetes of young rats: microenvironment and the influence of sympathectomy

1992 • 55 citations

2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain.

1992 • 52 citations

Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels

1994 • 49 citations

Effects of diabetes on reactivity of sciatic vasa nervorum in rats

1997 • 48 citations

Atrial Natriuretic Peptide and Prostacyclin Synergistically Mediate Hyperfiltration and Hyperperfusion of Diabetic Rats

1992 • 48 citations

Protein kinase C activity is altered in diabetic rat hearts

1992 • 48 citations

Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids

1990 • 46 citations

Protein kinase C in diabetic nephropathy

1995 • 45 citations

Inhibition of Protein Kinase C Restores Na⁺, K⁺‐ATPase Activity in Sciatic Nerve of Diabetic Mice

1992 • 44 citations

Transperineurial Arterioles in Human Sural Nerve

1991 • 42 citations

Trapped Immunoglobulins on Peripheral Nerve Myelin From Patients With Diabetes Mellitus

1986 • 41 citations

Sustained Recovery of Na+-K+-ATPase Activity in Sciatic Nerve of Diabetic Mice by Administration of H7 or Calphostin C, Inhibitors of PKC

1993 • 40 citations

Na,K-ATPase

1997 • 39 citations

Diabetic neuropathy. Structural analysis of nerve hydration by magnetic resonance spectroscopy

1988 • 39 citations

Increased endoneurial albumin in diabetic polyneuropathy

1985 • 39 citations

Activation of purified human protein kinase C α and β I isoenzymes in vitro by Ca2+, phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate

1993 • 39 citations

Effects of a nonpeptide endothelin-1 ETA antagonist on neurovascular function in diabetic rats: interaction with the renin-angiotensin system.

1996 • 37 citations

Relationship of endoneurial capillary abnormalities to type and severity of diabetic polyneuropathy

1990 • 34 citations

Protein kinase C agonists acutely normalize decreased ouabain-inhibitable respiration in diabetic rabbit nerve. Implications for (Na,K)-ATPase regulation and diabetic complications

1986 • 33 citations

Glomerular Hyperfiltration and Urinary Prostaglandins in Type 1 Diabetes Mellitus

1989 • 33 citations

Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets

1981 • 33 citations

Characterization of Endothelin Receptors and Effects of Endothelin on Diacylglycerol and Protein Kinase C in Retinal Capillary Pericytes

1989 • 32 citations

Modulation of endothelial autacoid release by protein kinase C: Feedback inhition or non‐specific attenuation of receptor‐dependent cell activation?

1993 • 32 citations

Diabetic Neuropathy

1988 • 31 citations

Structure-function relationships within peripheral nerves in diabetic neuropathy: the hydration hypothesis

1996 • 29 citations

Reduced glomerular sodium/potassium adenosine triphosphatase activity in acute streptozocin diabetes and its prevention by oral sorbinil

1985 • 29 citations

Nerve function and blood flow in Otsuka Long-Evans Tokushima Fatty rats with sucrose feeding: effect of an anticoagulant

1996 • 28 citations

Increased peripheral nerve microvessels in early experimental diabetic neuropathy: quantitative studies of nerve and dorsal root ganglia

1999 • 28 citations

Chronic elevation of endoneurial fluid pressure is associated with low-grade fiber pathology

1982 • 27 citations

Diminished specific activity of cytosolic protein kinase C in sciatic nerve of streptozocin-induced diabetic rats and its correction by dietary myo-inositol

1991 • 25 citations

DIABETIC EYE DISEASE

1996 • 23 citations

Role of enhanced arachidonate availability through phospholipase A2 pathway in mediation of increased prostaglandin synthesis by glomeruli from diabetic rats

1988 • 21 citations

Atrial natriuretic peptide and prostacyclin synergistically mediate hyperfiltration and hyperperfusion of diabetic rats

1992 • 21 citations

Transforming growth factor-beta 1 enhances glomerular collagen synthesis in diabetic rats

1993 • 20 citations

Trapped immunoglobulins on peripheral nerve myelin from patients with diabetes mellitus

1986 • 20 citations

Sustained recovery of Na(+)-K(+)-ATPase activity in sciatic nerve of diabetic mice by administration of H7 or calphostin C, inhibitors of PKC

1993 • 19 citations

Galactose Neuropathy: Structural Changes Evaluated by Nuclear Magnetic Resonance Spectroscopy

1987 • 19 citations

Modulation of Endothelial Cell Nitric Oxide Synthase Expression

1996 • 16 citations

Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats

1995 • 15 citations

Phosphoinositide metabolism, Na,K-ATPase and protein kinase C are altered in peripheral nerve from Zucker diabetic fatty rats (ZDF/Gmi-fa)

1997 • 14 citations

Action of protein kinase C in endothelin-induced contractions in rat aortic rings

1996 • 14 citations

Galactose neuropathy. Structural changes evaluated by nuclear magnetic resonance spectroscopy

1987 • 7 citations

Deleted Work

1955 • 0 citations