Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

1979 • 1,139 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.

1980 • 568 citations

Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones.

1986 • 526 citations

Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.

1985 • 471 citations

A protein associated with axon growth, GAP-43, is widely distributed and developmentally regulated in rat CNS

1986 • 435 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 389 citations

Phospholipid Metabolism in Stimulated Human Platelets

1980 • 367 citations

Phospholipids and cellular regulation

1985 • 331 citations

Activation of skeletal muscle myosin light chain kinase by calcium(2+) and calmodulin

1980 • 326 citations

Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids.

1986 • 309 citations

Direct activation of purified protein kinase C by unsaturated fatty acids (oleate and arachidonate) in the absence of phospholipids and Ca²⁺

1985 • 293 citations

Three distinct forms of rat brain protein kinase C: Differential response to unsaturated fatty acids

1987 • 239 citations

Phospholipid-sensitive Ca2+-dependent protein kinase from heart. I. Purification and general properties.

1982 • 235 citations

Polymyxin B is a more selective inhibitor for phospholipid-sensitive Ca2+-dependent protein kinase than for calmodulin-sensitive Ca2+-dependent protein kinase

1982 • 212 citations

Phospholipid-sensitive Ca2+-dependent protein phosphorylation system in various types of leukemic cells from human patients and in human leukemic cell lines HL60 and K562, and its inhibition by alkyl-lysophospholipid.

1983 • 207 citations

[118] 32P-labeling of a (Na+ + K+)-ATPase intermediate

1967 • 203 citations

Nerve growth cones isolated from fetal rat brain. III. Calcium- dependent protein phosphorylation

1985 • 185 citations

Role of substrate in imparting calcium and phospholipid requirements to protein kinase C activation

1987 • 168 citations

Identification and purification of sheep platelet phospholipase A2 isoforms. Activation by physiologic concentrations of calcium ion.

1986 • 147 citations

Stimulation by phosphatidylserine and calmodulin of calcium-dependent phosphorylation of endogenous proteins from cerebral cortex.

1980 • 132 citations

Effect of tamoxifen, a nonsteroidal antiestrogen, on phospholipid/calcium-dependent protein kinase and phosphorylation of its endogenous substrate proteins from the rat brain and ovary

1985 • 125 citations

Immunological quantitation of phospholipid/Ca2+-dependent protein kinase and its fragments. Tissue levels, subcellular distribution, and ontogenetic changes in brain and heart.

1986 • 114 citations

Purification to homogeneity, characterization and monoclonal antibodies of phospholipid-sensitive Ca2+-dependent protein kinase from spleen

1983 • 94 citations

Modulation of protein kinase C activity and [3H]phorbol 12,13-dibutyrate binding by various tumor promoters in mouse brain cytosol.

1985 • 88 citations

Modulation of Ca2+ control of dog and rabbit cardiac myofibrils by Mg2+. Comparison with rabbit skeletal myofibrils.

1976 • 71 citations

Phospholipase A2 stimulation during cell secretion in rat basophilic leukemia cells.

1986 • 54 citations

Role of substrate in determining the phospholipid specificity of protein kinase C activation

1987 • 51 citations

Phospholipase A2 activation in chemotactic peptide-stimulated HL60 granulocytes: Synergism between diacylglycerol and CA2+ in a protein kinase C-independent mechanism

1987 • 48 citations

Guanosine cyclic monophosphate-dependent protein kinase from foetal calf heart. Purification, general properties and catalytic subunit

1977 • 44 citations

Antileukemic agent alkyllysophospholipid regulates phosphorylation of distinct proteins in HL60 and K562 cells and differentiation of HL60 cells promoted by phorbol ester

1987 • 40 citations

Purification of three forms of lipocortin from bovine lung

1987 • 39 citations

Catalytic mechanism of Escherichia coli alkaline phosphatase: resolution of three variants of the acyl-enzyme mechanism

1980 • 22 citations