Potential Therapeutic Approaches to the Treatment or Prevention of Diabetic Neuropathy: Evidence from Experimental Studies

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Free radicals mediate endothelial cell dysfunction caused by elevated glucose

1992 • 566 citations

Peripheral Nerve Regeneration

1990 • 560 citations

Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes.

1975 • 471 citations

ENDONEURIAL BLOOD FLOW AND OXYGEN TENSION IN THE SCIATIC NERVES OF RATS WITH EXPERIMENTAL DIABETIC NEUROPATHY

1984 • 413 citations

Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system.

1992 • 323 citations

The influence of naloxone on analgesia produced by peripheral conditioning stimulation

1979 • 322 citations

Biochemistry and physiology of n‐3 fatty acids

1992 • 321 citations

Endogenous levels of nerve growth factor (NGF) are altered in experimental diabetes mellitus: A possible role for NGF in the pathogenesis of diabetic neuropathy

1990 • 316 citations

Regeneration and Repair of Myelinated Fibers in Sural-Nerve Biopsy Specimens from Patients with Diabetic Neuropathy Treated with Sorbinil

1988 • 298 citations

Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta

1991 • 283 citations

Nerve blood flow in early experimental diabetes in rats: relation to conduction deficits

1991 • 283 citations

Sural nerve oxygen tension in diabetes.

1986 • 258 citations

Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TxA2

1989 • 245 citations

IMPROVEMENT IN NERVE CONDUCTION FOLLOWING TREATMENT IN NEWLY DIAGNOSED DIABETICS

1971 • 244 citations

Diabetic neuropathy

1967 • 231 citations

Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: Role of polyol pathway

1992 • 216 citations

Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an aldose reductase inhibitor in streptozotocin-diabetic rats

1983 • 215 citations

Nerve Blood Flow and Oxygen Delivery In Normal, Diabetic, and Ischemic Neuropathy

1989 • 212 citations

Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals.

1991 • 210 citations

Enhancement of peripheral nerve regeneration

1990 • 202 citations

Dietary fish oil augments nitric oxide production or release in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1993 • 201 citations

Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta

1988 • 193 citations

Anti-oxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats

1993 • 185 citations

Effect of Insulin and Oral Glutathione on Glutathione Levels and Superoxide Dismutase Activities in Organs of Rats With Streptozocin-Induced Diabetes

1986 • 183 citations

Mechanism of impaired responses of cerebral arterioles during diabetes mellitus

1991 • 179 citations

Effect of Aminoguanidine on Functional and Structural Abnormalities in Peripheral Nerve of STZ-Induced Diabetic Rats

1992 • 178 citations

Hypoxic neuropathy Does hypoxia play a role in diabetic neuropathy?

1989 • 175 citations

Axo-glial dysjunction. A novel structural lesion that accounts for poorly reversible slowing of nerve conduction in the spontaneously diabetic bio-breeding rat.

1986 • 166 citations

Oxygen Free Radical Effects in Sciatic Nerve in Experimental Diabetes

1991 • 161 citations

Excessive Nonenzymatic Glycosylation of Peripheral and Central Nervous System Myelin Components in Diabetic Rats

1983 • 159 citations

Ischemic and reperfusion injury of rat peripheral nerve.

1989 • 158 citations

Retrograde Axonal Transport of Transmitter Enzymes, Fucose-Labeled Protein, and Nerve Growth Factor in Streptozotocin-Diabetic Rats

1981 • 143 citations

A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy

1990 • 142 citations

Angiotensin converting enzyme inhibition prevents development of muscle and nerve dysfunction and stimulates angiogenesis in streptozotocin-diabetic rats

1992 • 139 citations

Effects of aminoguanidine on peripheral nerve function and polyol pathway metabolites in streptozotocin-diabetic rats

1992 • 139 citations

Potential use of glutathione for the prevention and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat

1992 • 131 citations

Experimental chronic hypoxic neuropathy: relevance to diabetic neuropathy

1986 • 123 citations

Effect of Prostaglandin E1 Analogue TFC 612 on Diabetic Neuropathy in Streptozocin-Induced Diabetic Rats Comparison With Aldose Reductase Inhibitor ONO 2235

1989 • 123 citations

The Effect of γ‐Linolenic Acid on Human Diabetic Peripheral Neuropathy: A Double‐blind Placebo‐controlled Trial

1990 • 117 citations

PROSTACYCLIN AND NORADRENALINE IN PERIPHERAL NERVE OF CHRONIC EXPERIMENTAL DIABETES IN RATS

1989 • 116 citations

Recent advances in the pathogenesis of diabetic neuropathy. Clues from human diabetic neuropathy

1987 • 110 citations

Preventive effect of long-term aldose reductase inhibition (ponalrestat) on nerve conduction and sural nerve structure in the spontaneously diabetic Bio-Breeding rat.

1990 • 109 citations

Effects of Long-Term Aldose Reductase Inhibition on Development of Experimental Diabetic Neuropathy: Ultrastructural and Morphometric Studies of Sural Nerve in Streptozocin-Induced Diabetic Rats

1990 • 107 citations

Aldose reductase inhibitors and diabetic complications

1992 • 105 citations

The effects of Sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat

1986 • 102 citations

Development of diabetic neuropathy in the C57BL/Ks (db/db) mouse and its treatment with gangliosides

1984 • 102 citations

Essential Fatty Acid Diet Supplementation: Effects on Peripheral Nerve and Skeletal Muscle Function and Capillarization in Streptozocin-Induced Diabetic Rats

1991 • 101 citations

The influence of chronic experimental diabetes on contractile responses of rat isolated blood vessels

1985 • 100 citations

Ischemic conduction failure and energy metabolism in experimental diabetic neuropathy

1985 • 99 citations

Delayed nerve regeneration in streptozotocin diabetic rats

1986 • 98 citations

Effects of Chronic α-Adrenergic Receptor Blockade on Peripheral Nerve Conduction, Hypoxic Resistance, Polyols, Na+-K+-ATPase Activity, and Vascular Supply in STZ-D Rats

1991 • 97 citations

Vascular contraction induced by activation of membrane calcium ion channels is enhanced in streptozotocin-diabetes.

1990 • 97 citations

Hypoxic neuropathy: relevance to human diabetic neuropathy

1990 • 95 citations

Glycation of rat sciatic nerve tubulin in experimental diabetes mellitus

1991 • 93 citations

The roles of essential fatty acids in the development of diabetic neuropathy and other complications of diabetes mellitus.

1988 • 92 citations

Pathogenesis and prevention of diabetic neuropathy

1988 • 91 citations

Experimental diabetic neuropathy: similar changes of slow axonal transport and axonal size in different animal models

1988 • 87 citations

Exercise-induced conduction velocity increment: a marker of impaired peripheral nerve blood flow in diabetic neuropathy

1992 • 84 citations

Diabetes mellitus-associated decrease in nerve growth factor levels is reversed by allogeneic pancreatic islet transplantation

1991 • 83 citations

Impaired nerve regeneration in streptozotocin-diabetic rats. Effects of treatment with an aldose reductase inhibitor

1989 • 81 citations

THE EFFECT OF ALDOSE REDUCTASE INHIBITION ON THE PATTERN OF NERVE CONDUCTION DEFICITS IN DIABETIC RATS

1989 • 77 citations

Re‐expression of Nerve Growth Factor Receptor after Axonal Injury Recapitulates a Developmental Event in Motor Neurons: Differential Regulation when Regeneration is Allowed or Prevented

1990 • 75 citations

Blood pressure and vascular reactivity changes in spontaneously hypertensive rats fed fish oil

1991 • 75 citations

Aldose Reductase Inhibitors in the Treatment of Diabetic Neuropathy

1990 • 75 citations

Influence of streptozotocin-induced diabetes on myelinated nerve fibre maturation and on body growth in the rat

1981 • 73 citations

The Natriuretic Hormone: Recent Developments

1982 • 73 citations

Axonal transport of labeled protein and regeneration rate in nerves of streptozocin-diabetic rats

1980 • 71 citations

Reduced Glomerular Angiotensin II Receptor Density in Diabetes Mellitus in the Rat: Time Course and Mechanism*

1987 • 71 citations

Effect of prostaglandin E1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats. Comparison with aldose reductase inhibitor ONO 2235

1989 • 68 citations

Effect of Niceritrol on Streptozocin-Induced Diabetic Neuropathy in Rats

1992 • 68 citations

Enhanced vascular alpha-adrenergic neuroeffector system in diabetes: importance of calcium

1988 • 68 citations

Effect of hyperglycemia and the aldose reductase inhibitor tolrestat on sural nerve biochemistry and morphometry in advanced diabetic peripheral polyneuropathy

1993 • 68 citations

Nerve regeneration and serum levels of insulin-like growth factor-I in rats with streptozotocin-induced insulin deficiency

1989 • 67 citations

Correlations between nerve function and tissue oxygenation in diabetic patients: further clues to the aetiology of diabetic neuropathy?

1992 • 67 citations

Chronic exposure of cultured endothelial cells to eicosapentaenoic acid potentiates the release of endothelium‐derived relaxing factor(s)

1990 • 66 citations

Inhibition of cAMP- and Ca-dependent Cl- secretion by phorbol esters: inhibition of basolateral K+ channels

1993 • 66 citations

Regulation of rat nerve blood flow: role of epineurial alpha‐receptors.

1990 • 66 citations

Essential fatty acid treatment ? effects on nerve conduction, polyol pathway and axonal transport in streptozotocin diabetic rats

1989 • 64 citations

Aldose reductase inhibitors: Recent developments

1993 • 62 citations

Excessive nonenzymatic glycosylation of peripheral and central nervous system myelin components in diabetic rats

1983 • 62 citations

Reduced ciliary neuronotrophic factor-like activity in nerves from diabetic or galactose-fed rats

1992 • 61 citations

Alterations of the prostacyclin-thromboxane ratio in streptozotocin induced diabetic rats

1982 • 61 citations

Essential fatty acids prevent slowed nerve conduction in streptozotocin diabetic rats

1988 • 59 citations

Angiogenesis. The Growth of the Vascular System

1987 • 58 citations

Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus

1981 • 58 citations

Altered blood rheology in the pathogenesis of diabetic and other neuropathies

1988 • 57 citations

Myoinositol and function of peripheral nerves in human diabetics A CONTROLLED CLINICAL TRIAL

2009 • 55 citations

Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes

1989 • 55 citations

Amelioration of Nerve Na+-K+-ATPase Activity Independently of myo-Inositol Level by PGE1 Analogue OP-1206 · α-CD in Streptozocin-Induced Diabetic Rats

1991 • 55 citations

Ganglioside treatment of neuropathy in diabetic mice

1982 • 54 citations

Influence of dietary myoinositol on nerve conduction and inositol phospholipids in normal and diabetic rats.

1978 • 54 citations

Action of the stable prostacyclin analogue iloprost on microvascular tone and -permeability in the hamster cheek pouch

1987 • 54 citations

Clinical observations and experiments in diabetic neuropathy

1992 • 52 citations

Aldose Reductase Inhibition

1990 • 49 citations

Inhibition of Diabetes-Associated Complications by Nucleophilic Compounds

1991 • 47 citations

Beneficial Effect of Org 2766 in Treatment of Peripheral Neuropathy in Streptozocin-Induced Diabetic Rats

1989 • 47 citations

The effect of the calcium antagonist nifedipine on peripheral nerve function in streptozotocin-diabetic rats

1992 • 46 citations

Essential fatty acid diet supplementation. Effects on peripheral nerve and skeletal muscle function and capillarization in streptozocin-induced diabetic rats

1991 • 46 citations

Effects of chronic alpha-adrenergic receptor blockade on peripheral nerve conduction, hypoxic resistance, polyols, Na(+)-K(+)-ATPase activity, and vascular supply in STZ-D rats

1991 • 45 citations

Regional blood flow in resting and stimulated sciatic nerve of diabetic rats

1988 • 43 citations

Guanethidine-induced adrenergic sympathectomy augments endoneurial perfusion and lowers endoneurial microvascular resistance

1990 • 42 citations

Is resistance to ischaemic conduction failure induced by hypoxia?

1988 • 41 citations

Clinical efficacy of a stable prostacyclin analog, iloprost, in diabetic neuropathy

1991 • 40 citations

Microvascular Reactivity to Norepinephrine at Different Arteriolar Levels and Durations of Streptozocin-Induced Diabetes

1990 • 40 citations

Impaired nerve regeneration in streptozotocin-diabetic rats is improved by treatment with gangliosides

1990 • 39 citations

Elevated serum angiotensin I converting enzyme activity in type I, insulin-dependent diabetic subjects with persistent microalbuminuria

1992 • 39 citations

Prevention and reversal of motor and sensory peripheral nerve conduction abnormalities in streptozotocin-diabetic rats by the prostacyclin analogue iloprost

1993 • 38 citations

Effects of PP-56 and Vitamin E on Platelet Hyperaggregability, Fatty Acid Abnormalities, and Clinical Manifestations in Streptozocin-Induced Diabetic Rats

1991 • 38 citations

Rapid reversal of a motor nerve conduction deficit in streptozotocin-diabetic rats by the angiotensin converting enzyme inhibitor lisinopril

1993 • 37 citations

Retrograde Axonal Transport of 125I-Nerve Growth Factor in Rat Heal Mesenteric Nerves: Effect of Streptozocin Diabetes

1985 • 37 citations

Dissociation between biochemical and functional effects of the aldose reductase inhibitor, ponalrestat, on peripheral nerve in diabetic rats

1992 • 37 citations

Effect of niceritrol on streptozocin-induced diabetic neuropathy in rats

1992 • 36 citations

Changes in Blood Pressure, Body Fluids, Circulating Angiotensin II and Aldosterone, with Improved Diabetic Control

1982 • 35 citations

The pharmacology of diabetic neuropathy

1992 • 35 citations

Effect of 4-methylcatechol on sciatic nerve growth factor level and motor nerve conduction velocity in experimental diabetic neuropathic process in rats

1992 • 34 citations

Ganglioside Treatment and Improved Axonal Regeneration Capacity in Experimental Diabetic Neuropathy

1989 • 34 citations

Slow Axonal Transport of Structural Polypeptides in Rat, Early Changes in Streptozocin Diabetes, and Effect of Insulin Treatment

1989 • 33 citations

Aldose reductase and myo-inositol in endothelial cell dysfunction caused by elevated glucose.

1992 • 33 citations

Effects of Sorbinil, Dietary myo-Inositol Supplementation, and Insulin on Resolution of Neuroaxonal Dystrophy in Mesenteric Nerves of Streptozocin-Induced Diabetic Rats

1991 • 32 citations

Treatment of Diabetic Neuropathy, A New Approach

1993 • 31 citations

The effects of dietary treatment with essential fatty acids on sciatic nerve conduction and activity of the Na⁺/K⁺ pump in streptozotocin‐diabetic rats

1992 • 31 citations

Beneficial effect of Org 2766 in treatment of peripheral neuropathy in streptozocin-induced diabetic rats

1989 • 31 citations

Slow Axonal Transport Impairment of Cytoskeletal Proteins in Streptozociti‐Induced Diabetic Neuropathy

1989 • 30 citations

A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats

1988 • 29 citations

Amelioration of nerve Na(+)-K(+)-ATPase activity independently of myo-inositol level by PGE1 analogue OP-1206.alpha-CD in streptozocin-induced diabetic rats

1991 • 25 citations

Altered aortic and cremaster muscle prostaglandin synthesis in diabetic rats

1985 • 25 citations

Early arteriolar disturbances following streptozotocin-induced diabetes mellitus in adult mice

1980 • 25 citations

Neurofilament Protein Phosphorylation in Spinal Cord of Experimentally Diabetic Rats

1991 • 22 citations

Ganglioside treatment and improved axonal regeneration capacity in experimental diabetic neuropathy

1989 • 21 citations

Guanethidine adrenergic neuropathy: an animal model of selective autonomic neuropathy

1988 • 21 citations

Chronic low frequency electrical activation for one week corrects nerve conduction velocity deficits in rats with diabetes of three months duration

1989 • 20 citations

Microvascular reactivity to norepinephrine at different arteriolar levels and durations of streptozocin-induced diabetes

1990 • 20 citations

A new prostaglandin E1 analogue (TFC-612) improves the reduction in motor nerve conduction velocity in spontaneously diabetic GK (Goto-Kakizaki) rats

1990 • 19 citations

Adenosine Triphosphatase Activity in Sciatic Nerve Tissue of Streptozocin-Induced Diabetic Rats with and without High Dietary Sucrose: Effect of Aldose Reductase Inhibitors

1991 • 19 citations

Central hypoxaemia in rats provokes neurological defects similar to those seen in experimental diabetes mellitus: Evidence for a partial role of endoneurial hypoxia in diabetic neuropathy

1991 • 19 citations

Retrograde axonal transport of 125I-nerve growth factor in rat ileal mesenteric nerves. Effect of streptozocin diabetes

1985 • 19 citations

Inhibition of diabetes-associated complications by nucleophilic compounds

1991 • 18 citations

The Ca2+ antagonist nimodipine counteracts the onset of an experimental neuropathy in streptozotocin induced, diabetic rats

1992 • 18 citations

Diabetes mellitus, the Renin-Angiotensin System, and Angiotensin-Converting Enzyme Inhibition

1990 • 17 citations

Effect of a prostaglandin I2 derivative (Iloprost) on peripheral neuropathy of diabetic rats

1992 • 17 citations

PLASMA ANGIOTENSIN II AND THE CONTROL OF DIABETES MELLITUS

1980 • 17 citations

Restriction Fragment Length Polymorphisms at the GLUT4 and GLUT1 Gene Loci in Type 2 Diabetes

1992 • 16 citations

Ganglioside treatment of diabetic rats; Effects on nerve adenosine triphosphatase activity and motor nerve conduction velocity

1988 • 15 citations

Impaired induction of ornithine decarboxylase activity following nerve crush in the streptozotocin-diabetic rat

1987 • 13 citations

Mechanisms in rabbit aorta for hyperglycaemia-induced alterations in angiotensin II and norepinephrine effects

1992 • 12 citations

Sciatic Nerve ATPase Activity Is Unaffected in Diabetic Mutant C57BI/Ks (db/db) Mice

1987 • 10 citations

Ganglioside stimulation of nerve growth factor synthesis in cultured rat Schwann cells.

1990 • 9 citations

Impaired induction of nerve ornithine decarboxylase activity in the streptozotocin‐diabetic rat is prevented by the aldose reductase inhibitor ponalrestat

1990 • 8 citations

Ganglioside Stimulation of Nerve Growth Factor Synthesis in Cultured Rat Schwann Cells.

1991 • 8 citations

Reduced number of angiotensin II receptors on platelets in insulin-dependent diabetes

1986 • 7 citations

Sciatic nerve ATPase activity is unaffected in diabetic mutant C57Bl/Ks (db/db) mice

1987 • 5 citations

Lisinopril

1988 • 4 citations

The effect of mixed bovine brain gangliosides on hypoxic conduction block in control and streptozotocin-diabetic rats

1992 • 2 citations