Regulation of Endothelial Constitutive Nitric Oxide Synthase by Protein Kinase C

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Flow-induced release of endothelium-derived relaxing factor

1986 • 1,379 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Chelerythrine is a potent and specific inhibitor of protein kinase C

1990 • 1,208 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

1994 • 941 citations

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

1989 • 905 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Nanogram nitrite and nitrate determination in environmental and biological materials by vanadium(III) reduction with chemiluminescence detection

1989 • 867 citations

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

1993 • 778 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

1992 • 616 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

1992 • 477 citations

Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. Possible role of protein kinase C activation.

1991 • 437 citations

Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters

1987 • 379 citations

Cellular mechanism of endothelin-1 release by angiotensin and vasopressin.

1991 • 243 citations

Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies

1993 • 191 citations

Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to endothelin-1 in septic rats

1997 • 142 citations

Organization of the bovine gene encoding the endothelial nitric oxide synthase

1994 • 124 citations

Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways

1992 • 112 citations

Possible involvement of protein kinase C in platelet-derived growth factor-stimulated DNA synthesis in vascular smooth muscle cells

1987 • 106 citations

Staurosporine, a protein kinase C inhibitor interferes with proliferation of arterial smooth muscle cells

1989 • 106 citations

Protein kinase C alterations in the fetal rat brain after global ischemia.

1988 • 92 citations

Release of NO and EDRF from cultured bovine aortic endothelial cells

1989 • 86 citations

A phorbol ester inhibits the release of endothelium-derived relaxing factor

1987 • 63 citations

Protein phosphorylation in cultured endothelial cells

1986 • 54 citations

Phorbol dibutyrate inhibits release and action of endothelium-derived relaxing factor(s) in canine blood vessels.

1989 • 48 citations

Release of endothelium‐derived relaxing factor from pig cultured aortic endothelial cells, as assessed by changes in endothelial cell cyclic GMP content, is inhibited by a phorbol ester

1990 • 45 citations

Interference of phorbolesters with endothelium-dependent vascular smooth muscle relaxation

1986 • 45 citations

Release of nitrogen oxides from cultured bovine aortic endothelial cells is not impaired by calcium channel antagonists.

1991 • 40 citations

Identification of a protein transiently phosphorylated by activators of endothelial cell function as the heat-shock protein HSP27. A possible role for protein kinase C

1992 • 37 citations

Modulation of endothelial autacoid release by protein kinase C: Feedback inhition or non‐specific attenuation of receptor‐dependent cell activation?

1993 • 32 citations

Impairment of relaxations to acetylcholine and nitric oxide by a phorbol ester in rat isolated aorta

1990 • 28 citations

Chelerythrine, a selective protein kinase C inhibitor, counteracts pyrogen-induced expression of tissue factor without effect on thrombomodulin down-regulation in endothelial cells

1993 • 27 citations

Phorbol-12,13-dibutyrate-induced vasoconstriction in vivo: characterization of response in genetic hypertension.

1990 • 19 citations

Antagonism of acetylcholine-mediated relaxation of rabbit pulmonary arteries by phorbol myristate acetate.

1988 • 14 citations

Vascular responsiveness to phorbol esters in coarctation-hypertensive rats

1990 • 13 citations

Contractile response of spontaneously hypertensive rat caudal artery to phorbol esters.

1988 • 12 citations