Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2.

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1994 • 552 citations

Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.

1993 • 521 citations

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

1994 • 444 citations

Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2

1993 • 424 citations

The Ca2(+)-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells.

1991 • 413 citations

Inhibition of Macrophage Ca2+-independent Phospholipase A2 by Bromoenol Lactone and Trifluoromethyl Ketones

1995 • 401 citations

Serum rapidly stimulates ouabain-sensitive 86-RB+ influx in quiescent 3T3 cells.

1975 • 329 citations

Renal cytochrome P450-related arachidonate metabolite inhibits (Na+ + K+)ATPase

1985 • 314 citations

Banting Lecture 1986: Does a Common Mechanism Induce the Diverse Complications of Diabetes?

1987 • 275 citations

Increased Synthesis of Prostaglandin-E-like Material by Platelets from Patients with Diabetes Mellitus

1977 • 195 citations

Thrombin-induced phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in human platelets.

1993 • 191 citations

Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.

1991 • 191 citations

Phospholipase A2 and signal transduction.

1992 • 187 citations

Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues

1994 • 186 citations

Role for Protein Kinase C in the Mediation of Increased Fibronectin Accumulation by Mesangial Cells Grown in High-Glucose Medium

1993 • 178 citations

Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus.

1985 • 171 citations

Identification of NaK-ATPase inhibitors in human plasma as nonesterified fatty acids and lysophospholipids.

1986 • 167 citations

Structure-function relationships of cation binding in the Na+/K+-ATPase

1993 • 157 citations

Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells.

1993 • 141 citations

Cellular and Molecular Abnormalities in the Vascular Endothelium of Diabetes Mellitus

1994 • 129 citations

Prostaglandin E2 inhibits sodium transport in rabbit cortical collecting duct by increasing intracellular calcium.

1991 • 125 citations

Effects of isolation and culture on prostaglandin synthesis by porcine aortic endothelial and smooth muscle cells

1982 • 120 citations

Intracellular signaling in the regulation of renal Na-K-ATPase. II. Role of eicosanoids.

1993 • 118 citations

Characterization of Glucose-Induced In Situ Protein Kinase C Activity in Cultured Vascular Smooth Muscle Cells

1992 • 118 citations

Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide.

1992 • 115 citations

Conformation-dependent phosphorylation of Na,K-ATPase by protein kinase A and protein kinase C.

1994 • 109 citations

Protein Kinase C Agonists Acutely Normalize Decreased Ouabain-inhibitable Respiration in Diabetic Rabbit Nerve: Implications for (Na,K)-ATPase Regulation and Diabetic Complications

1986 • 109 citations

Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia

1994 • 106 citations

The hormone-sensitive hepatic Na+-pump. Evidence for regulation by diacylglycerol and tumor promoters.

1986 • 102 citations

Altered retinal metabolism in diabetes. II. Measurement of sodium-potassium ATPase and total sodium and potassium in individual retinal layers.

1986 • 102 citations

Solubilization and properties of Ca2+-dependent human platelet phospholipase A2

1986 • 94 citations

Growth factors activate the bumetanide-sensitive Na+/K+/Cl-cotransport in hamster fibroblasts.

1986 • 78 citations

In vivo phosphorylation of the Na,K-ATPase alpha subunit in sciatic nerves of control and diabetic rats: effects of protein kinase modulators.

1994 • 62 citations

Lipid metabolism and signal transduction in endothelial cells

1990 • 56 citations

Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium

1993 • 56 citations

Elevated glucose alters eicosanoid release from porcine aortic endothelial cells.

1988 • 48 citations

Role of protein kinase C in insulin activation of the Na-K pump in cultured skeletal muscle

1994 • 41 citations

Human and rodent muscle Na(+)-K(+)-ATPase in diabetes related to insulin, starvation, and training

1994 • 39 citations

Protein kinase C agonists acutely normalize decreased ouabain-inhibitable respiration in diabetic rabbit nerve. Implications for (Na,K)-ATPase regulation and diabetic complications

1986 • 33 citations

Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells

1992 • 32 citations

Effect of fasting and streptozotocin-diabetes on the coronary flow in isolated rat hearts: A possible role of endogenous catecholamines and prostaglandins

1977 • 31 citations

PGE2 inhibits Na-K-ATPase activity and ouabain binding in MDCK cells

1993 • 29 citations

Altered aortic and cremaster muscle prostaglandin synthesis in diabetic rats

1985 • 25 citations

Expression, purofocation and biochemical comparison of natural and recombinant human non-pancreatic phospholipase A2

1992 • 22 citations

Ca(2+)-sensitive cytosolic phospholipase A2 (cPLA2) in human platelets.

1993 • 10 citations

Insulin Action on the (Na+,K+)ATPase

1985 • 6 citations

Deleted Work

1955 • 0 citations