PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH.

Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

1974 • 1,004 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1976 • 668 citations

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

1976 • 600 citations

Coronary Arterial Smooth Muscle Contraction by a Substance Released from Platelets: Evidence That It Is Thromboxane A ₂

1976 • 504 citations

Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.

1980 • 481 citations

Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of ‘free’ iron in biological systems by using bleomycin-dependent degradation of DNA

1981 • 469 citations

Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands

1977 • 421 citations

Superoxide production in experimental brain injury

1986 • 420 citations

Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in cats.

1985 • 296 citations

Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats.

1980 • 290 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron salts

1983 • 289 citations

Cerebral Arteriolar Damage by Arachidonic Acid and Prostaglandin G ₂

1980 • 245 citations

Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats.

1981 • 222 citations

Oxygen radicals mediate the cerebral arteriolar dilation from arachidonate and bradykinin in cats.

1984 • 215 citations

Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland.

1975 • 209 citations

Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats

1977 • 208 citations

Superoxide generation and reversal of acetylcholine-induced cerebral arteriolar dilation after acute hypertension.

1985 • 205 citations

Studies on Cytochrome c Peroxidase

1966 • 179 citations

Subcellular localization of prostaglandin-forming cyclooxygenase in Swiss mouse 3T3 fibroblasts by electron microscopic immunocytochemistry.

1980 • 174 citations

Prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. Inactivation and activation by heme and other metalloporphyrins.

1978 • 167 citations

Cyclooxygenase Products of Arachidonic Acid Metabolism in Cat Cerebral Cortex After Experimental Concussive Brain Injury

1981 • 167 citations

The spectra of the enzyme-substrate complexes of catalase and peroxidase

1952 • 163 citations

Reduction of hydroperoxides in the prostaglandin biosynthetic pathway by a microsomal peroxidase.

1979 • 162 citations

Spectral properties of the higher oxidation states of prostaglandin H synthase.

1985 • 159 citations

Chemical Nature of the Secondary Hydrogen Peroxide Compound Formed by Cytochrome-C Peroxidase and Horseradish Peroxidase

1952 • 153 citations

One-electron reactions in biochemical systems as studied by pulse radiolysis. IV. Oxidation of dihydronicotinamide-adenine dinucleotide

1971 • 153 citations

Analysis and computer simulation of aerobic oxidation of reduced nicotinamide adenine dinucleotide catalyzed by horseradish peroxidase

1977 • 143 citations

Increased phospholipase C activity after experimental brain injury

1982 • 143 citations

Electron-nuclear double resonance of horseradish peroxidase compound I. Detection of the porphyrin pi-cation radical.

1981 • 141 citations

Mechanism of cerebral arteriolar abnormalities after acute hypertension

1981 • 131 citations

Reaction of peroxidase with reduced nicotinamide-adenine dinucleotide and reduced nicotinamide-adenine dinucleotide phosphate

1965 • 129 citations

Effects of oxygen radicals on cerebral arterioles

1985 • 128 citations

Oxidation reactions by prostaglandin cyclooxygenase-hydroperoxidase.

1981 • 124 citations

Oxygen 18 investigation of the prostaglandin synthetase-dependent co-oxidation of diphenylisobenzofuran.

1979 • 66 citations

Electron-nuclear double resonance of the hydrogen peroxide compound of cytochrome c peroxidase: identification of the free radical site with a methionyl cluster.

1979 • 62 citations

In vitro O2 uptake and histochemical fiber type of resting hamster muscles

1984 • 42 citations

Chapter 5 Enzymes in the arachidonic acid cascade

1983 • 24 citations

Effects of 15-hydroperoxy-eicosatetraenoic acid (15-HPETE) on cerebral arterioles of cats

1984 • 12 citations

Reduction in cerebral arteriolar oxygen consumption by arachidonate

1985 • 8 citations

HYDROGEN PEROXIDE, OXYGEN, SUPEROXIDE ANION, SINGLET OXYGEN AND PEROXIDASE

1979 • 7 citations