The Sorbitol Pathway and the Complications of Diabetes

Formation of Polyols by the Lens of the Rat with ‘Sugar’ Cataract

1959 • 431 citations

Sorbitol Pathway: Presence in Nerve and Cord with Substrate Accumulation in Diabetes

1966 • 395 citations

Studies on the metabolism of semen

1946 • 343 citations

Le mécanisme de la transformation de glucose en fructose par les vésicules séminales

1956 • 180 citations

ACTIVE TRANSPORT INTO THE HUMAN ERYTHROCYTE: EVIDENCE FROM COMPARATIVE KINETICS AND COMPETITION AMONG MONOSACCHARIDES

1951 • 178 citations

The Sorbitol Pathway: Enzyme Localization and Content in Normal and Diabetic Nerve and Cord

1968 • 175 citations

The Course of Juvenile Diabetes Treated with Unmeasured Diet

1965 • 169 citations

Variations in motor conduction velocity produced by acute changes of the metabolic state in diabetic patients

1968 • 168 citations

POLYOL ACCUMULATIONS IN NERVOUS TISSUE OF RATS WITH EXPERIMENTAL DIABETES AND GALACTOSAEMIA *

1967 • 166 citations

Osmotic changes in experimental galactose cataracts

1962 • 150 citations

SCHWANN-CELL ABNORMALITIES IN DIABETIC NEUROPATHY

1965 • 139 citations

Factors affecting the formation of sugar alcohols in ocular lens

1963 • 124 citations

Metabolic alterations in the human erythrocyte produced by increases in glucose concentration

1971 • 122 citations

INCREASED CEREBROSPINAL-FLUID PRESSURE DURING TREATMENT OF DIABETIC KETOSIS

1971 • 110 citations

Osmotic Changes caused by the Accumulation of Dulcitol in the Lenses of Rats fed with Galactose

1962 • 106 citations

The effect of an aldose reductase inhibitor on the galactose-exposed rabbit lens

1968 • 101 citations

CHANGES IN REFRACTION IN DIABETES MELLITUS

1925 • 99 citations

Role of Sorbitol Pathway in Neuropathy

1973 • 86 citations

Studies on the metabolism of semen. 6. Role of hormones. Effect of castration, hypophysectomy and diabetes. Relation between blood glucose and seminal fructose

1950 • 84 citations

Polyol dehydrogenases. 4. Crystallization of the <scp>l</scp>-iditol dehydrogenase of sheep liver

1962 • 79 citations

PURIFICATION AND PROPERTIES OF BRAIN ALDOSE REDUCTASE AND <scp>l</scp>‐HEXONATE DEHYDROGENASE*

1967 • 75 citations

Enzymic Studies on TPN L-Hexonate Dehydrogenase from Rat Liver

1961 • 75 citations

Aldose reductase activity in the lens and other tissues

1966 • 70 citations

Diabetic Neuropathy: a Metabolic or a Vascular Disease?

1965 • 69 citations

Nerve Conduction Defect in Galactose-fed Rats

1972 • 67 citations

ACUTE CEREBRAL ŒDEMA DURING TREATMENT OF HYPERGLYCÆMIA

1968 • 65 citations

A BIOCHEMICAL AND MORPHOLOGIC STUDY OF MYELINATION AND DEMYELINATION

1958 • 59 citations

Action of Insulin on the Permeability of Cells to Sorbitol

1951 • 57 citations

Free sugars in alloxan diabetic rat nerve

1966 • 57 citations

Inhibition of Glucose-Induced Release of Insulin by Aldose Reductase Inhibitors

1972 • 55 citations

INOSITOL CHANGES IN NERVE AND LENS OF GALACTOSE FED RATS¹

1968 • 51 citations

The accumulation of dulcitol and water in rabbit lens incubated with galactose

1962 • 49 citations

The sorbitol pathway in diabetes and galactosemia: enzyme and sobstrate localization and changes in kidney.

1968 • 37 citations

Identification of fructose in mammalian nerve

1964 • 20 citations

Laevulose in the Blood of the Human Foetus

1924 • 18 citations

THE FRUCTOSE CONTENT OF SPINAL FLUID

1937 • 17 citations

Free fructose in human cerebrospinal fluid

1966 • 17 citations