Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs)

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

2001 • 788 citations

Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc‐binding environments (HEXXHXXGXXH and Met‐turn) and topologies and should be grouped into a common family, the ‘metzincins’

1993 • 729 citations

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases

1995 • 691 citations

Membrane protein secretases

1997 • 634 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3

1998 • 604 citations

The ADAM gene family: surface proteins with adhesion and protease activity

2000 • 582 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding

1999 • 558 citations

Regulated Cleavage of a Contact-Mediated Axon Repellent

2000 • 522 citations

Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis

1997 • 516 citations

Matrix metalloproteinase inhibitors

1997 • 509 citations

Functional Analysis of the Domain Structure of Tumor Necrosis Factor-α Converting Enzyme

2000 • 496 citations

A metalloprotease-disintegrin participating in myoblast fusion

1995 • 492 citations

ADAMs: focus on the protease domain

1998 • 472 citations

A unique signature identifies a family of zinc‐dependent metallopeptidases

1989 • 453 citations

Evidence for a Role of a Tumor Necrosis Factor-α (TNF-α)-converting Enzyme-like Protease in Shedding of TRANCE, a TNF Family Member Involved in Osteoclastogenesis and Dendritic Cell Survival

1999 • 414 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

The in vitro activity of ADAM‐10 is inhibited by TIMP‐1 and TIMP‐3

2000 • 396 citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

1997 • 363 citations

Intracellular maturation and localization of the tumour necrosis factor α convertase (TACE)

2000 • 350 citations

KUZ, a Conserved Metalloprotease-Disintegrin Protein with Two Roles in Drosophila Neurogenesis

1996 • 331 citations

Notch1 Signaling Promotes the Maturation of CD4 and CD8 SP Thymocytes

2000 • 317 citations

A Novel, Secreted Form of Human ADAM 12 (Meltrin α) Provokes Myogenesis in Vivo

1998 • 315 citations

Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity

1999 • 312 citations

ADAM 12-S Cleaves IGFBP-3 and IGFBP-5 and Is Inhibited by TIMP-3

2000 • 309 citations

ADAMs in Fertilization and Development

1996 • 259 citations

Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades

1999 • 248 citations

Membrane-Bound TNF Supports Secondary Lymphoid Organ Structure but Is Subservient to Secreted TNF in Driving Autoimmune Inflammation

2001 • 247 citations

The Cysteine-Rich Domain of Human Adam 12 Supports Cell Adhesion through Syndecans and Triggers Signaling Events That Lead to β1 Integrin–Dependent Cell Spreading

2000 • 246 citations

Remarkable roles of proteolysis on and beyond the cell surface

2000 • 235 citations

Regulation of the α‐secretase ADAM10 by its prodomain and proprotein convertases

2001 • 232 citations

kuzbanian-mediated cleavage of Drosophila Notch

2002 • 226 citations

Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis

2001 • 225 citations

Specific Interaction of the Recombinant Disintegrin-like Domain of MDC-15 (Metargidin, ADAM-15) with Integrin αvβ3

1998 • 214 citations

MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.

1996 • 213 citations

RGD-independent Binding of Integrin α9β1 to the ADAM-12 and -15 Disintegrin Domains Mediates Cell-Cell Interaction

2000 • 211 citations

Mice Lacking the Metalloprotease-Disintegrin MDC9 (ADAM9) Have No Evident Major Abnormalities during Development or Adult Life

2002 • 209 citations

Identification and Characterization of a Pro-tumor Necrosis Factor-α-processing Enzyme from the ADAM Family of Zinc Metalloproteases

1997 • 204 citations

ADAM-TS5, ADAM-TS6, and ADAM-TS7, Novel Members of a New Family of Zinc Metalloproteases

1999 • 198 citations

The Τumor Necrosis Factor-α Converting Enzyme (TACE): A Unique Metalloproteinase with Highly Defined Substrate Selectivity

2002 • 195 citations

Interaction of metargidin (ADAM-15) with αvβ3 and α5β1 integrins on different haemopoietic cells

1999 • 193 citations

Meltrin γ (ADAM-9) mediates cellular adhesion through α6β1 integrin, leading to a marked induction of fibroblast cell motility

2000 • 190 citations

Viper Venom Disintegrins and Related Molecules

1998 • 189 citations

Altered Tumor Necrosis Factor-α (TNF-α) Processing in Adipocytes and Increased Expression of Transmembrane TNF-α in Obesity

2002 • 189 citations

Human ADAM 12 (Meltrin α) Is an Active Metalloprotease

1998 • 188 citations

Interaction of the Metalloprotease Disintegrins MDC9 and MDC15 with Two SH3 Domain-containing Proteins, Endophilin I and SH3PX1

1999 • 182 citations

Metargidin, a Membrane-anchored Metalloprotease-Disintegrin Protein with an RGD Integrin Binding Sequence

1996 • 170 citations

Stimulation-induced Down-regulation of Tumor Necrosis Factor-α Converting Enzyme

2000 • 167 citations

Intracellular Maturation of the Mouse Metalloprotease Disintegrin MDC15

1998 • 167 citations

LPS-induced liver injury in<scp>d</scp>-galactosamine-sensitized mice requires secreted TNF-α and the TNF-p55 receptor

2000 • 163 citations

Xenopus ADAM 13 is a metalloprotease required for cranial neural crest-cell migration

2001 • 162 citations

The HHQK Domain of β-Amyloid Provides a Structural Basis for the Immunopathology of Alzheimer's Disease

1998 • 161 citations

Specific Sequence Elements Are Required for the Expression of Functional Tumor Necrosis Factor-α-converting Enzyme (TACE)

1999 • 156 citations

Structure–Function Analysis of the ADAM Family of Disintegrin-Like and Metalloproteinase-Containing Proteins (Review)

1999 • 155 citations

Binding of ADAM12, a Marker of Skeletal Muscle Regeneration, to the Muscle-specific Actin-binding Protein, α-Actinin-2, Is Required for Myoblast Fusion

2000 • 154 citations

Characterization of METH-1/ADAMTS1 Processing Reveals Two Distinct Active Forms

2000 • 145 citations

The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs

2002 • 144 citations

ADAMs and cell fusion

1996 • 143 citations

Structure, function and evolutionary relationship of proteins containing a disintegrin domain

1992 • 138 citations

Tumor Necrosis Factor α Induces a Metalloprotease-Disintegrin, ADAM8 (CD 156): Implications for Neuron–Glia Interactions during Neurodegeneration

2000 • 132 citations

Evidence for Regulation of the Tumor Necrosis Factor α-Convertase (TACE) by Protein-tyrosine Phosphatase PTPH1

2002 • 129 citations

Phosphorylation-dependent Interactions between ADAM15 Cytoplasmic Domain and Src Family Protein-tyrosine Kinases

2002 • 128 citations

Tissue Inhibitor of Metalloproteinases-3 Inhibits Shedding of L-selectin from Leukocytes

1999 • 126 citations

Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28

2000 • 123 citations

The importance of shedding of membrane proteins for cytokine biology.

2000 • 122 citations

Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types

1996 • 121 citations

Matrix metalloproteinase inhibitors 1998

1998 • 115 citations

Evidence for Distinct Serine Protease Activities with a Potential Role in Processing the Sperm Protein Fertilin

1997 • 113 citations

ADAM 13: A Novel ADAM Expressed in Somitic Mesoderm and Neural Crest Cells duringXenopus laevisDevelopment

1997 • 109 citations

Cloning and Initial Characterization of Mouse Meltrin β and Analysis of the Expression of Four MetalloproteaseDisintegrins in Bone Cells

1998 • 109 citations

Spatially- and temporally-restricted expression of meltrin α (ADAM12) and β (ADAM19) in mouse embryo

1998 • 102 citations

New α-Substituted Succinate-Based Hydroxamic Acids as TNFα Convertase Inhibitors

1999 • 90 citations

Pharmacological profile of PKF242‐484 and PKF241‐466, novel dual inhibitors of TNF‐α converting enzyme and matrix metalloproteinases, in models of airway inflammation

2002 • 89 citations

Sperm disintegrins, egg integrins, and other cell adhesion molecules of mammalian gamete plasma membrane interactions

1999 • 88 citations

ADAMTS: A novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats

1999 • 86 citations

Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor.

1997 • 85 citations

Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.

1999 • 84 citations

Isolation and characterization of

2014 • 82 citations

The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone

2000 • 82 citations

Synthesis and biological activity of selective pipecolic acid-based TNF-α converting enzyme (TACE) inhibitors

2002 • 75 citations

The Lymphocyte Metalloprotease MDC-L (ADAM 28) Is a Ligand for the Integrin α4β1

2002 • 74 citations

Design of Selective and Soluble Inhibitors of Tumor Necrosis Factor-α Converting Enzyme (TACE)

2001 • 74 citations

Implication of APP Secretases in Notch Signaling

2001 • 74 citations

Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases.

2001 • 74 citations

Biology of TACE inhibition

2001 • 73 citations

A Novel Metalloproteinase Associated with Brain Myelin Membranes

1989 • 72 citations

Catalytic activity of ADAM28

2001 • 72 citations

A novel inhibitor of tumor necrosis factor-α converting enzyme ameliorates polycystic kidney disease

2001 • 71 citations

PACSIN2 Is a Regulator of the Metalloprotease/Disintegrin ADAM13

2000 • 70 citations

Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1′ group

2002 • 70 citations

Effect of TNF-α–Converting Enzyme Inhibitor on Insulin Resistance in Fructose-Fed Rats

2002 • 68 citations

Intracellular Processing of Metalloprotease Disintegrin ADAM12

2002 • 65 citations

Metalloproteinase super–families and drug design

1994 • 62 citations

Meltrin α cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src

2000 • 61 citations

Expression and Enzymatic Activity of Human Disintegrin and Metalloproteinase ADAM19/Meltrin Beta

2001 • 60 citations

Intracellular Activation of Human Adamalysin 19/Disintegrin and Metalloproteinase 19 by Furin Occurs via One of the Two Consecutive Recognition Sites

2002 • 60 citations

Processing of tumor necrosis factor by the membrane‐bound TNF‐α‐converting enzyme, but not its truncated soluble form

2001 • 57 citations

Role for ADAM-family proteinases as membrane protein secretases

1999 • 54 citations

Cloning and Expression in Pichia pastoris of Metalloprotease Domain of ADAM 9 Catalytically Active against Fibronectin

2001 • 54 citations

Advances in developmental biochemistry

1992 • 53 citations

Intracellular maturation and localization of the tumour necrosis factor α convertase (TACE)

2000 • 53 citations

Structure−Activity Relationship of Hydroxamate-Based Inhibitors on the Secretases that Cleave the Amyloid Precursor Protein, Angiotensin Converting Enzyme, CD23, and Pro-Tumor Necrosis Factor-α

2002 • 52 citations

β-Aryl-Succinic Acid Hydroxamates as Dual Inhibitors of Matrix Metalloproteinases and Tumor Necrosis Factor Alpha Converting Enzyme

2002 • 51 citations

Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-α converting enzyme

2001 • 51 citations

TNFα processing enzyme inhibitors prevent aspirin‐induced TNFα release and protect against gastric mucosal injury in rats

1998 • 49 citations

The Effect of a Metalloproteinase Inhibitor (GI5402) on Tumor Necrosis Factor- (TNF-) and TNF- Receptors During Human Endotoxemia

1999 • 48 citations

KB-R7785, a novel matrix metalloproteinase inhibitor, exerts its antidiabetic effect by inhibiting tumor necrosis factor-α production

1997 • 46 citations

Anti-arthritic activity of hydroxamic acid-based pseudopeptide inhibitors of matrix metalloproteinases and TNFα processing

1997 • 44 citations

Molecular cloning and characterization of a human metalloprotease disintegrin— a novel marker for dendritic cell differentiation

2000 • 44 citations

Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

2001 • 43 citations

Treatment with BB-94, a broad spectrum inhibitor of zinc-dependent metalloproteinases, causes deviation of the cytokine profile towards Type-2 in experimental pulmonary tuberculosis in Balb/c mice

2000 • 42 citations

Metalloprotease-disintegrin ADAM 12 interacts with α-actinin-1

2001 • 41 citations

Notch on the cutting edge

1997 • 40 citations

Neural Crest-Specific and General Expression of Distinct Metalloprotease–Disintegrins in EarlyXenopus laevisDevelopment

1998 • 38 citations

Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28

2000 • 32 citations

Proteases as Targets for Therapy

2000 • 31 citations

Identification, sequence analysis and expression of transcripts encoding a putative metalloproteinase, eMDC II, in human and macaque epididymis

1999 • 26 citations

Evidence for an interaction of the metalloprotease‒disintegrin tumour necrosis factor α convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease‒disintegrin MDC9 with a novel MAD2-related protein, MAD2β

1999 • 22 citations

Neuronal specification: Notch signals Kuz it's cleaved

1997 • 13 citations

Metalloproteinase inhibitor prevents hepatic injury in endotoxemic mice

1998 • 12 citations