Structure−Activity Relationship of Hydroxamate-Based Inhibitors on the Secretases that Cleave the Amyloid Precursor Protein, Angiotensin Converting Enzyme, CD23, and Pro-Tumor Necrosis Factor-α

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Phase separation of integral membrane proteins in Triton X-114 solution.

1981 • 3,366 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

1998 • 922 citations

Membrane protein secretases

1997 • 634 citations

MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS

1998 • 576 citations

Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding

1999 • 558 citations

Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease

1995 • 431 citations

Increased Activity‐Regulating and Neuroprotective Efficacy of α‐Secretase‐Derived Secreted Amyloid Precursor Protein Conferred by a C‐Terminal Heparin‐Binding Domain

1996 • 387 citations

Intracellular maturation and localization of the tumour necrosis factor α convertase (TACE)

2000 • 350 citations

Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity

1999 • 312 citations

Membrane-anchored metalloprotease MDC9 has an α-secretase activity responsible for processing the amyloid precursor protein

1999 • 260 citations

Isolation of two differentially glycosylated forms of peptidyl-dipeptidase A (angiotensin converting enzyme) from pig brain: a re-evaluation of their role in neuropeptide metabolism

1987 • 190 citations

Coordinated Expression of β‐Amyloid Precursor Protein and the Putative β‐Secretase BACE and α‐Secretase ADAM10 in Mouse and Human Brain

2000 • 179 citations

Constitutive α‐secretase cleavage of the β‐amyloid precursor protein in the furin‐deficient LoVo cell line: involvement of the pro‐hormone convertase 7 and the disintegrin metalloprotease ADAM10

2001 • 124 citations

Mitogen‐Activated Protein Kinase‐Dependent and Protein Kinase C‐Dependent Pathways Link the m1 Muscarinic Receptor to β‐Amyloid Precursor Protein Secretion

1998 • 122 citations

Characterization of a secretase activity which releases angiotensin-converting enzyme from the membrane

1993 • 111 citations

A High Throughput Fluorogenic Substrate for Interstitial Collagenase (MMP-1) and Gelatinase (MMP-9)

1993 • 103 citations

Mechanism of formation of human IgE-binding factors (soluble CD23): III. Evidence for a receptor (Fc epsilon RII)-associated proteolytic activity.

1990 • 89 citations

Pro-Tumor Necrosis Factor-α Processing Activity Is Tightly Controlled by a Component That Does Not Affect Notch Processing

1998 • 88 citations

Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-α converting enzyme

2001 • 88 citations

Amyloid precursor protein secretion and βA4 amyloid generation are not mutually exclusive

1994 • 75 citations

Angiotensin-converting enzyme secretase is inhibited by zinc metalloprotease inhibitors and requires its substrate to be inserted in a lipid bilayer

1997 • 52 citations

The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor‐α convertase

1998 • 49 citations

Unaltered Cleavage and Secretion of Angiotensin-converting Enzyme in Tumor Necrosis Factor-α-converting Enzyme-deficient Mice

1999 • 49 citations

CD23 (Fc∊RII) release from cell membranes is mediated by a membrane-bound metalloprotease

1998 • 40 citations

A Point Mutation in the Juxtamembrane Stalk of Human Angiotensin I-converting Enzyme Invokes the Action of a Distinct Secretase

2001 • 28 citations

Roles of the juxtamembrane and extracellular domains of angiotensin-converting enzyme in ectodomain shedding

2001 • 27 citations

Angiotensin-converting enzyme and the amyloid precursor protein secretases

1999 • 9 citations

Angiotensin converting enzyme

2021 • 9 citations

Selective inhibition of low affinity IgE receptor (CD23) processing: P1′ bicyclomethyl substituents

1999 • 8 citations