Specific Sequence Elements Are Required for the Expression of Functional Tumor Necrosis Factor-α-converting Enzyme (TACE)

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Analytical ultracentrifugation in biochemistry and polymer science

1995 • 1,970 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

PROTEINS, AMINO ACIDS AND PEPTIDES as Ions and Dipolar Ions

1943 • 897 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

Proteins, Amino Acids and Peptides as Ions and Dipolar Ions

1944 • 443 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme

1998 • 376 citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

1997 • 363 citations

Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity

1999 • 312 citations

Stromelysin‐1: Three‐dimensional structure of the inhibited catalytic domain and of the C‐truncated proenzyme

1995 • 289 citations

A protein-folding reaction under kinetic control

1992 • 284 citations

Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.

1995 • 247 citations

Human pro-Tumor Necrosis Factor Is a Homotrimer

1996 • 150 citations

Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus.

1994 • 138 citations

Localization of Furin to the trans-Golgi Network and Recycling from the Cell Surface Involves Ser and Tyr Residues within the Cytoplasmic Domain

1995 • 131 citations

Activation of snake venom metalloproteinases by a cysteine switch‐like mechanism

1993 • 118 citations

Assembly of SIV Virus-like Particles Containing Envelope Proteins Using a Baculovirus Expression System

1995 • 91 citations

APMA (4-Aminophenylmercuric Acetate) Activation of Stromelysin-1 Involves Protein Interactions in Addition to Those with Cysteine-75 in the Propeptide

1996 • 64 citations

Roles of the Propeptide and Metal Ions in the Folding and Stability of the Catalytic Domain of Stromelysin (Matrix Metalloproteinase 3)

1996 • 56 citations

The glycosylation of human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) is important for the efficient intracellular transport of the envelope precursor gp160

1995 • 53 citations

Processing and secretion of tumor necrosis factor alpha in endotoxin-treated Mono Mac 6 cells are dependent on phorbol myristate acetate

1992 • 48 citations

Metalloproteinases as Targets for Anti-Inflammatory Drugs

1999 • 46 citations

Length of the Linking Domain of Human pro-Tumor Necrosis Factor Determines the Cleavage Processing

1996 • 41 citations

Engineering the Independent Folding of the Subtilisin BPN‘ Pro-Domain: Correlation of Pro-Domain Stability with the Rate of Subtilisin Folding

1998 • 38 citations

Thermodynamic data for biochemistry and biotechnology

1987 • 27 citations

Expression and Purification of Correctly Processed, Active Human TACE Catalytic Domain inSaccharomyces cerevisiae

1998 • 22 citations