Evidence for Regulation of the Tumor Necrosis Factor α-Convertase (TACE) by Protein-tyrosine Phosphatase PTPH1

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1999 • 1,484 citations

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

1997 • 1,371 citations

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

1999 • 1,115 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

1998 • 922 citations

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

2002 • 727 citations

PDZ Domains: Structural Modules for Protein Complex Assembly

2002 • 696 citations

MEMBRANE-ANCHORED GROWTH FACTORS

1993 • 676 citations

Membrane protein secretases

1997 • 634 citations

The ADAM gene family: surface proteins with adhesion and protease activity

2000 • 582 citations

Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding

1999 • 558 citations

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

1992 • 557 citations

A metalloprotease-disintegrin, MDC9/meltrin-gamma /ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor

1998 • 523 citations

Regulated Cleavage of a Contact-Mediated Axon Repellent

2000 • 522 citations

Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis

1997 • 516 citations

Functional Analysis of the Domain Structure of Tumor Necrosis Factor-α Converting Enzyme

2000 • 496 citations

ADAMs: focus on the protease domain

1998 • 472 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

Shedding of Syndecan-1 and -4 Ectodomains Is Regulated by Multiple Signaling Pathways and Mediated by a Timp-3–Sensitive Metalloproteinase

2000 • 409 citations

Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors

1996 • 404 citations

Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells

2002 • 354 citations

Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity

1999 • 312 citations

Tumor Necrosis Factor-α-converting Enzyme Is Required for Cleavage of erbB4/HER4

2000 • 310 citations

Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

1991 • 287 citations

Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades

1999 • 248 citations

Remarkable roles of proteolysis on and beyond the cell surface

2000 • 235 citations

Mice Lacking the Metalloprotease-Disintegrin MDC9 (ADAM9) Have No Evident Major Abnormalities during Development or Adult Life

2002 • 209 citations

Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin.

1991 • 203 citations

Role of Src Kinases in the ADAM-mediated Release of L1 Adhesion Molecule from Human Tumor Cells

2000 • 186 citations

The Shedding of Membrane-anchored Heparin-binding Epidermal-like Growth Factor Is Regulated by the Raf/Mitogen-activated Protein Kinase Cascade and by Cell Adhesion and Spreading

1999 • 185 citations

Interaction of the Metalloprotease Disintegrins MDC9 and MDC15 with Two SH3 Domain-containing Proteins, Endophilin I and SH3PX1

1999 • 182 citations

Roles of Meltrin β/ADAM19 in the Processing of Neuregulin

2001 • 181 citations

Metargidin, a Membrane-anchored Metalloprotease-Disintegrin Protein with an RGD Integrin Binding Sequence

1996 • 170 citations

Intracellular Maturation of the Mouse Metalloprotease Disintegrin MDC15

1998 • 167 citations

Stimulation-induced Down-regulation of Tumor Necrosis Factor-α Converting Enzyme

2000 • 167 citations

Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor.

1992 • 152 citations

Metalloprotease-dependent Protransforming Growth Factor-α Ectodomain Shedding in the Absence of Tumor Necrosis Factor-α-converting Enzyme

2001 • 133 citations

14-3-3 proteins: biological function and domain structure

1995 • 125 citations

Role of the Juxtamembrane Domains of the Transforming Growth Factor-α Precursor and the β-Amyloid Precursor Protein in Regulated Ectodomain Shedding

1997 • 120 citations

Subcellular localization of intracellular protein tyrosine phosphatases in T cells

2000 • 113 citations

Serine Phosphorylation-dependent Association of the Band 4.1-related Protein-tyrosine Phosphatase PTPH1 with 14-3-3ॆ Protein

1997 • 110 citations

Identification of the Cell Cycle Regulator VCP (p97/CDC48) as a Substrate of the Band 4.1-related Protein-tyrosine Phosphatase PTPH1

1999 • 106 citations

Cutting edge: a dominant negative form of TNF-alpha converting enzyme inhibits proTNF and TNFRII secretion.

1999 • 101 citations

Structural requirements for inducible shedding of the p55 tumor necrosis factor receptor.

1994 • 94 citations

Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.

1999 • 84 citations

14-3-3 Proteins: Hot numbers in signal transduction

1995 • 82 citations

Cutting Edge: A Dominant Negative Form of TNF-α Converting Enzyme Inhibits ProTNF and TNFRII Secretion

1999 • 81 citations

14-3-3 proteins and growth control

2000 • 60 citations

Evidence for an interaction of the metalloprotease–disintegrin tumour necrosis factor α convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease–disintegrin MDC9 with a novel MAD2-related protein, MAD2β

1999 • 53 citations

Transmembrane kit ligand cleavage does not require a signal in the cytoplasmic domain and occurs at a site dependent on spacing from the membrane.

1994 • 44 citations

Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal‐associated proteins

1993 • 13 citations

cDNA Cloning of New Protein Tyrosine Phosphatases in the Human Colon

1992 • 6 citations