Chapter 6 Evolving view of quaternary structures of ligand-gated ion channels

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1997 • 8,634 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

1991 • 2,240 citations

Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits

1994 • 1,943 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

1996 • 1,703 citations

Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs

1992 • 1,067 citations

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

1994 • 1,039 citations

Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons

1995 • 1,017 citations

A P2X purinoceptor expressed by a subset of sensory neurons

1995 • 1,014 citations

Acetylcholine receptor channel imaged in the open state

1995 • 1,002 citations

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

1995 • 988 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Primary Structure And Functional Expression of the 5HT ₃ Receptor, A Serotonin-gated Ion Channel

1991 • 976 citations

Structure of the MscL Homolog from Mycobacterium tuberculosis : A Gated Mechanosensitive Ion Channel

1998 • 972 citations

Determination of the subunit stoichiometry of a voltage-activated potassium channel

1991 • 925 citations

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

1994 • 924 citations

Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

1996 • 882 citations

The TINS/TiPS Lecture the molecular biology of mammalian glutamate receptor channels

1993 • 882 citations

The Tetrameric Structure of a Glutamate Receptor Channel

1998 • 790 citations

Sequence differences between glycosylated and non-glycosylated Asn-X-Thr/Ser acceptor sites: implications for protein engineering

1990 • 750 citations

Association and Stoichiometry of KATP Channel Subunits

1997 • 697 citations

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins

1995 • 614 citations

Acetylcholine Receptor: Complex of Homologous Subunits

1980 • 594 citations

The benzodiazepine binding site of GABAA receptors

1997 • 589 citations

The 5-HT3B subunit is a major determinant of serotonin-receptor function

1999 • 555 citations

P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels

1998 • 540 citations

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

1995 • 535 citations

A VIEW OF SUR/K_IR6.X, K_ATP CHANNELS

1998 • 514 citations

Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. Evidence for a hetero-oligomeric structure in rat brain.

1992 • 505 citations

Structure and Function of Cyclic Nucleotide-Gated Channels

1996 • 499 citations

Evidence for a Tetrameric Structure of Recombinant NMDA Receptors

1998 • 487 citations

Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor

1991 • 463 citations

Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons

1993 • 446 citations

Alteration of ionic selectivity of a K+ channel by mutation of the H5 region

1991 • 445 citations

A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem

1995 • 429 citations

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

1991 • 426 citations

Quaternary Structure of the Native GABA_A Receptor Determined by Electron Microscopic Image Analysis

1994 • 423 citations

Stoichiometry of a Recombinant GABA_AReceptor

1996 • 423 citations

The heterotetrameric architecture of the epithelial sodium channel (ENaC)

1998 • 408 citations

Cloning and Functional Characterization of a Novel ATP-sensitive Potassium Channel Ubiquitously Expressed in Rat Tissues, including Pancreatic Islets, Pituitary, Skeletal Muscle, and Heart

1995 • 405 citations

An antagonist-insensitive P2X receptor expressed in epithelia and brain.

1996 • 404 citations

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

1993 • 401 citations

Nucleotide receptors

1997 • 399 citations

Ligand-gated ion channels in the brain: The amino acid receptor superfamily

1990 • 397 citations

Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel

1995 • 390 citations

The functions and consensus motifs of nine types of peptide segments that form different types of nucleotide‐binding sites

1994 • 388 citations

Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.

1988 • 388 citations

Purification by affinity chromatography of the glycine receptor of rat spinal cord.

1982 • 370 citations

Structure and function of voltage‐gated sodium channels

1998 • 349 citations

P2X4: an ATP-activated ionotropic receptor cloned from rat brain.

1996 • 339 citations

Pharmacology and electrophysiology of ATP-activated ion channels

1992 • 326 citations

A Superfamily of ATPases with Diverse Functions Containing Either Classical or Deviant ATP-binding Motif

1993 • 322 citations

Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors).

1995 • 319 citations

Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure

1991 • 313 citations

Two physically distinct pores in the dimeric CIC-0 chloride channel

1996 • 281 citations

Quaternary structure of the acetylcholine receptor

1985 • 281 citations

A P2X purinoceptor cDNA conferring a novel pharmacological profile

1995 • 279 citations

Unraveling the modular design of glutamate-gated ion channels

1995 • 272 citations

P2X Receptors: An Emerging Channel Family

1996 • 265 citations

Ionic permeability of, and divalent cation effects on, two ATP‐gated cation channels (P2X receptors) expressed in mammalian cells.

1996 • 257 citations

Homodimeric architecture of a CIC-type chloride ion channel

1996 • 255 citations

Neuronal nicotinic receptors: Molecular organization and regulations

1995 • 254 citations

Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli

1997 • 251 citations

Central P2X₄and P2X₆Channel Subunits Coassemble into a Novel Heteromeric ATP Receptor

1998 • 246 citations

GABAc receptors

1995 • 243 citations

Biochemical Characterization and Localization of a Non‐N‐Methyl‐D‐Aspartate Glutamate Receptor in Rat Brain

1992 • 242 citations

Biochemical properties of acetylcholine receptor subunits from Torpedo californica

1979 • 239 citations

The benzodiazepine binding site of GABAA receptors

1997 • 238 citations

GABAC receptors: relatively simple transmitter-gated ion channels?

1996 • 236 citations

Electrophysiological and Biochemical Evidence That DEG/ENaC Cation Channels Are Composed of Nine Subunits

1998 • 234 citations

Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists

1989 • 232 citations

Structure of the NMDA Receptor Channel M2 Segment Inferred from the Accessibility of Substituted Cysteines

1996 • 228 citations

Subunit Stoichiometry of the Epithelial Sodium Channel

1998 • 222 citations

Determination of the subunit stoichiometry of an inwardly rectifying potassium channel

1995 • 222 citations

Characterization of Recombinant Human P2X₄ Receptor Reveals Pharmacological Differences to the Rat Homologue

1997 • 220 citations

Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel.

1994 • 219 citations

Identification of amino acid residues contributing to the pore of a P2X receptor

1997 • 207 citations

The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex

1995 • 205 citations

A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain.

1996 • 205 citations

Electrophysiological properties of P2X‐purinoceptors in rat superior cervical, nodose and guinea‐pig coeliac neurones.

1995 • 200 citations

Active multi-subunit ACh receptor assembled by translation of heterologous mRNA in Xenopus oocytes

1981 • 197 citations

Neurotransmitter-gated ion channels as unconventional allosteric proteins

1994 • 197 citations

The Emerging Three‐Dimensional Structure of a Receptor

1996 • 197 citations

A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain

1996 • 188 citations

Subunit positional effects revealed by novel heteromeric inwardly rectifying K+ channels.

1996 • 185 citations

Assembly of the inhibitory glycine receptor: Identification of amino acid sequence motifs governing subunit stoichiometry

1993 • 183 citations

Effect of pyridoxal phosphate on the DNA binding site of activated hepatic glucocorticoid receptor.

1978 • 182 citations

The 5-HT3 Receptor Channel

1995 • 180 citations

Identification of Acetylcholine Receptor Channel-Lining Residues in the M1 Segment of the .alpha.-Subunit

1995 • 179 citations

Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli.

1996 • 177 citations

The InsP3 receptor and intracellular Ca2+ signaling

1997 • 166 citations

Stoichiometry of a recombinant GABAA receptor deduced from mutation-induced rectification

1993 • 164 citations

Desensitization of the P2X₂ receptor controlled by alternative splicing

1997 • 160 citations

Structural conservation of ion conduction pathways in K channels and glutamate receptors.

1995 • 158 citations

Protein chemical characterization and immunocytochemical localization of the NMDA receptor subunit NMDA R1.

1993 • 155 citations

Families of ion channels with two hydrophobic segments

1996 • 150 citations

FROM GABA_A RECEPTOR DIVERSITY EMERGES A UNIFIED VISION OF GABAergic INHIBITION

1998 • 147 citations

Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels.

1991 • 146 citations

A tetrameric subunit stoichiometry for a glutamate receptor–channel complex

1998 • 137 citations

A domain contributing to the ion channel of ATP-gated P2X2 receptors identified by the substituted cysteine accessibility method.

1998 • 136 citations

Ultrastructure of the 5‐Hydroxytryptamine₃ Receptor

1995 • 132 citations

Molecular composition of GABAC receptors

1998 • 131 citations

Expression of Recombinant Homo-oligomeric 5-Hydroxytryptamine3 Receptors Provides New Insights into Their Maturation and Structure

1995 • 129 citations

Molecular cloning and functional expression of a novel rat heart P2X purinoceptor

1996 • 126 citations

Purification, Reconstitution, and Subunit Composition of a Voltage-Gated Chloride Channel from Torpedo Electroplax

1994 • 125 citations

Baculovirus Expression Provides Direct Evidence for Heteromeric Assembly of P2X₂and P2X₃Receptors

1997 • 123 citations

Homomeric and native α7 acetylcholine receptors exhibit remarkably similar but non‐identical pharmacological properties, suggesting that the native receptor is a heteromeric protein complex

1993 • 122 citations

Membrane Topology of an ATP-gated Ion Channel (P2X Receptor)

1998 • 121 citations

Subunit-dependent assembly of inward-rectifier K ⁺ channels

1995 • 121 citations

Stoichiometry of Recombinant N-Methyl-<scp>d</scp>-Aspartate Receptor Channels Inferred from Single-channel Current Patterns

1997 • 119 citations

A Domain Contributing to the Ion Channel of ATP-Gated P2X₂Receptors Identified by the Substituted Cysteine Accessibility Method

1998 • 117 citations

Images of purified Shaker potassium channels

1994 • 111 citations

Number and Stoichiometry of Subunits in the Native Atrial G-protein-gated K+ Channel, IKACh

1998 • 111 citations

Cloning and Tissue Distribution of a Novel P2X Receptor from Rat Brain

1996 • 109 citations

The Phe-Met-Arg-Phe-amide-activated Sodium Channel Is a Tetramer

1998 • 103 citations

The GABAA/benzodiazepine receptor is a heterotetramer of homologous alpha and beta subunits.

1987 • 101 citations

Nucleotide receptors in the nervous system

1997 • 100 citations

Cloned Ligand-gated Channels Activated by Extracellular ATP (P2X Receptors)

1997 • 99 citations

Pentameric subunit stoichiometry of a neuronal glutamate receptor.

1996 • 94 citations

Cloning and Pharmacological Characterization of a Fourth P2X Receptor Subtype Widely Expressed in Brain and Peripheral Tissues Including Various Endocrine Tissues

1996 • 94 citations

Chloride Channel Expression with the Tandem Construct of α6-β2 GABAA Receptor Subunit Requires a Monomeric Subunit of α6 or γ2

1995 • 80 citations

P2X purinoceptor plethora

1996 • 76 citations

Topological analysis of the ATP‐gated ionotrophic P2X₂ receptor subunit

1998 • 74 citations

P2X Receptors: A Third Major Class of Ligand‐Gated Ion Channels

2007 • 62 citations

Design and pharmacology of selective P₂‐purinoceptor antagonists

1996 • 62 citations

Structure and function of glutamate and nicotinic acetylcholine receptors

1995 • 62 citations

Molecular Assembly of the Extracellular Domain of P2X2, an ATP-Gated Ion Channel

1997 • 61 citations

Presynaptic potassium channels

1996 • 57 citations

Characterization of a Mouse Serotonin 5‐HT₃ Receptor Purified from Mammalian Cells

1998 • 56 citations

Structural Motif and Characteristics of the Extracellular Domain of P2XReceptors

1997 • 56 citations

Promiscuous coassembly of serotonin 5-HT ₃ and nicotinic α4 receptor subunits into Ca ²⁺ -permeable ion channels

1998 • 56 citations

Solubilization and molecular size determination of the P2x purinoceptor from rat vas deferens.

1992 • 55 citations

Cooperative interactions among subunits of a voltage-dependent potassium channel. Evidence from expression of concatenated cDNAs.

1992 • 55 citations

Core sequence of ATP regulatory module in receptor guanylate cyclases

1993 • 53 citations

Tetrameric Subunit Structure of the Native Brain Inwardly Rectifying Potassium Channel Kir 2.2

1998 • 52 citations

A Hexameric Transmembrane Pore Revealed by Two-dimensional Crystallization of the Large Mechanosensitive Ion Channel (MscL) ofEscherichia coli

1998 • 51 citations

ATP binding site of P2X channel proteins: structural similarities with class II aminoacyl‐tRNA synthetases

1998 • 47 citations

Ionotropic glutamate receptors: new types and new concepts

1997 • 46 citations

A study of the oligomeric state of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring glutamate receptors in the synaptic junctions of porcine brain

1996 • 38 citations

Molecular Properties of 5‐Hydroxytryptamine3 Receptor‐Type Binding Sites Purified from NG1O8‐15 Cells

1992 • 37 citations

Blue Native Page as a Useful Method for the Analysis of the Assembly of Distinct Combinations of Nicotinic Acetylcholine Receptor Subunits

1999 • 36 citations

Purification of the 5-hydroxytryptamine 5-HT3 receptor from NCB20 cells.

1990 • 31 citations

Evidence that porcine native 5-HT3 receptors do not contain nicotinic acetylcholine receptor subunits

1998 • 21 citations

Native Serotonin 5‐HT₃ Receptors Expressed in Xenopus Oocytes Differ from Homopentameric 5‐HT₃ Receptors

1997 • 18 citations

Homologies and disparities of glutamate receptors: A critical analysis

1993 • 11 citations

Modelling of binding sites of the nicotinic acetylcholine receptor and their relation to models of the whole receptor.

1990 • 7 citations

Modelling of binding sites of the nicotinic acetylcholine receptor and their relation to models of the whole receptor.

1990 • 4 citations