The InsP3 receptor and intracellular Ca2+ signaling

Capacitative calcium entry revisited

1990 • 1,499 citations

Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400

1989 • 1,039 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

1994 • 818 citations

trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry

1996 • 688 citations

TRPC1, a human homolog of a Drosophila store-operated channel.

1995 • 623 citations

FK506 binding protein associated with the calcium release channel (ryanodine receptor).

1992 • 525 citations

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

1995 • 484 citations

Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor

1996 • 457 citations

Cloning and Functional Expression of a Human Ca2+-Permeable Cation Channel Activated by Calcium Store Depletion

1996 • 391 citations

The Drosophila Light-Activated Conductance Is Composed of the Two Channels TRP and TRPL

1996 • 368 citations

The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum.

1993 • 353 citations

The ligand binding site and transduction mechanism in the inositol-1,4,5-triphosphate receptor.

1990 • 339 citations

Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.

1995 • 288 citations

Co-expression in vertebrate tissues and cell lines of multiple inositol 1,4,5-trisphosphate (InsP3) receptors with distinct affinities for InsP3.

1994 • 279 citations

Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Trisphosphate Receptor

1996 • 268 citations

The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner.

1991 • 262 citations

Regulation of the TRP Ca2+ Channel by INAD in Drosophila Photoreceptors

1996 • 256 citations

Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

1992 • 253 citations

Mutational Analysis of the Ligand Binding Site of the Inositol 1,4,5-Trisphosphate Receptor

1996 • 229 citations

Activation of recombinant trp by thapsigargin in Sf9 insect cells

1994 • 226 citations

Heterotetrameric Complex Formation of Inositol 1,4,5-Trisphosphate Receptor Subunits

1995 • 214 citations

Regulation of the Inositol 1,4,5-Trisphosphate Receptor by Tyrosine Phosphorylation

1996 • 212 citations

Widespread expression of inositol 1,4,5-trisphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system.

1993 • 201 citations

Adenophostins, newly discovered metabolites of Penicillium brevicompactum, act as potent agonists of the inositol 1,4,5-trisphosphate receptor.

1994 • 200 citations

Intracellular channels

1994 • 186 citations

Cell-cycle calcium transients driven by cyclic changes in inositol trisphosphate levels

1994 • 180 citations

Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.

1995 • 179 citations

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.

1994 • 177 citations

Reorganization of the Endoplasmic Reticulum during Meiotic Maturation of the Mouse Oocyte

1995 • 175 citations

Molecular recognition of inositol polyphosphates by intracellular receptors and metabolic enzymes

1989 • 163 citations

Structure-function relationships of the mouse inositol 1,4,5-trisphosphate receptor.

1991 • 160 citations

Cyclic AMP-dependent phosphorylation of an immunoaffinity-purified homotetrameric inositol 1,4,5-trisphosphate receptor (type I) increases Ca2+ flux in reconstituted lipid vesicles.

1994 • 156 citations

Characterization of an Exchange Reaction between Soluble FKBP-12 and the FKBP·Ryanodine Receptor Complex

1995 • 145 citations

The inositol 1,4,5-trisphosphate receptor is essential for T-cell receptor signaling.

1995 • 143 citations

Inositol 1,4,5-Trisphosphate receptor causes formation of ER cisternal stacks in transfected fibroblasts and in cerebellar purkinje cells

1994 • 138 citations

Quantal calcium release by purified reconstituted inositol 1,4,5-trisphosphate receptors

1992 • 136 citations

The calmodulin-binding domain in the mouse type 1 inositol 1,4,5-trisphosphate receptor

1995 • 128 citations

Heteroligomers of Type-I and Type-III Inositol Trisphosphate Receptors in WB Rat Liver Epithelial Cells

1995 • 128 citations

Characterization of a Cytosolic and a Luminal Ca2+ Binding Site in the Type I Inositol 1,4,5-Trisphosphate Receptor

1996 • 126 citations

A localized elevation of cytosolic free calcium is associated with cytokinesis in the zebrafish embryo.

1995 • 124 citations

Developmental Changes in the Distribution of the Endoplasmic Reticulum and Inositol 1,4,5-Trisphosphate Receptors and the Spatial Pattern of Ca2+ Release during Maturation of Hamster Oocytes

1995 • 124 citations

Plasma membrane inositol 1,4,5-trisphosphate receptor of lymphocytes: selective enrichment in sialic acid and unique binding specificity.

1992 • 120 citations

The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse.

1997 • 120 citations

Appearance of a Novel Ca2+ Influx Pathway in Sf9 Insect Cells Following Expression of the Transient Receptor Potential-like (trpl) Protein of Drosophila

1994 • 108 citations

Coexpression of Drosophila TRP and TRP-like proteins in Xenopus oocytes reconstitutes capacitative Ca ²⁺ entry

1996 • 105 citations

The Type 1 Inositol 1,4,5-Trisphosphate Receptor Gene Is Altered in theopisthotonosMouse

1997 • 101 citations

Type-I, Type-II and Type-III Inositol 1,4,5-Trisphosphate Receptor Co-Immunoprecipitation as Evidence for the Existence of Heterotetrameric Receptor Complexes

1995 • 97 citations

Local perinuclear calcium signals associated with mitosis-entry in early sea urchin embryos.

1996 • 93 citations

Phosphorylation of the InaD Gene Product, a Photoreceptor Membrane Protein Required for Recovery of Visual Excitation

1996 • 90 citations

Ca2+ differentially regulates the ligand-affinity states of type 1 and type 3 inositol 1,4,5-trisphosphate receptors

1997 • 88 citations

Monoclonal antibodies distinctively recognizing the subtypes of inositol 1,4,5‐trisphosphate receptor: Application to the studies on inflammatory cells

1994 • 87 citations

Adenophostin‐medicated quantal Ca²⁺ release in the purified and reconstituted inositol 1,4,5‐trisphosphate receptor type 1

1995 • 83 citations

Calcium waves along the cleavage furrows in cleavage-stage Xenopus embryos and its inhibition by heparin.

1996 • 81 citations

A Comparison of Sperm- and IP3-Induced Ca2+Release in Activated and Aging Mouse Oocytes

1996 • 75 citations

The Human Type 1 Inositol 1,4,5-Trisphosphate Receptor from T Lymphocytes

1995 • 75 citations

Expression of inositol 1,4,5-trisphosphate receptors changes the Ca2+ signal of Xenopus oocytes

1996 • 68 citations

Developmental Expression of the Inositol 1,4,5-Trisphosphate Receptor and Structural Changes in the Endoplasmic Reticulum during Oogenesis and Meiotic Maturation ofXenopus laevis

1997 • 68 citations

Native structure and arrangement of inositol-1,4,5-trisphosphate receptor molecules in bovine cerebellar Purkinje cells as studied by quick-freeze deep-etch electron microscopy.

1996 • 66 citations

The COOH-terminal Domain of Drosophila TRP Channels Confers Thapsigargin Sensitivity

1996 • 65 citations

Ins(1,4,5)P3 activates Drosophila cation channel Trpl in recombinant baculovirus-infected Sf9 insect cells

1995 • 63 citations

Subtypes of inositol 1,4,5‐trisphosphate receptor in human hematopoietic cell lines: Dynamic aspects of their cell‐type specific expression

1994 • 63 citations

Degradation of Inositol 1,4,5-Trisphosphate Receptors during Cell Stimulation Is a Specific Process Mediated by Cysteine Protease Activity

1996 • 57 citations

Mechanisms responsible for quantal Ca2+ release from inositol trisphosphate-sensitive calcium stores

1996 • 47 citations

The inositol 1,4,5-trisphosphate receptor binding sites of platelet membranes. pH-dependency, inhibition by polymeric sulphates, and the possible presence of arginine at the binding site

1990 • 42 citations

Isolation and characterization of vascular smooth muscle inositol 1,4,5-trisphosphate receptor

1996 • 41 citations

Calcium signalling: Setting store by calcium channels

1996 • 30 citations

Molecular recognition at the myo-inositol 1,4,5-trisphosphate receptor. 3-position substituted myo-inositol 1,4,5-trisphosphate analogues reveal the binding and Ca2+ release requirements for high affinity interaction with the myo-inositol 1,4,5-trisphosphate receptor.

1994 • 30 citations

Regulation of inositol trisphosphate-induced membrane currents in Xenopus oocytes by a Jurkat cell calcium influx factor

1996 • 28 citations

6-Deoxy-6-hydroxymethyl scyllo-inositol 1,2,4-trisphosphate: A potent agonist at the inositol 1,4,5-trisphosphate receptor

1996 • 17 citations