Primary Structure And Functional Expression of the 5HT ₃ Receptor, A Serotonin-gated Ion Channel

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction

1986 • 3,400 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

A Method for Isolation of Intact, Translationally Active Ribonucleic Acid

1983 • 1,469 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

1986 • 1,255 citations

Cloning by functional expression of a member of the glutamate receptor family

1989 • 1,009 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Molecular biology of GABA _A receptors

1990 • 947 citations

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

1990 • 923 citations

Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

1987 • 866 citations

Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs

1985 • 845 citations

TWO KINDS OF TRYPTAMINE RECEPTOR

1957 • 838 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

1987 • 730 citations

Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor

1988 • 691 citations

5-HT3 receptors are membrane ion channels

1989 • 630 citations

SERUM VASOCONSTRICTOR (SEROTONIN)

1948 • 530 citations

THE PATHWAY OF EUKARYOTIC mRNA FORMATION

1983 • 429 citations

Ligand-gated ion channels in the brain: The amino acid receptor superfamily

1990 • 397 citations

Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.

1988 • 388 citations

The pharmacology and function of 5-HT3receptors

1986 • 380 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

5-Hydroxytryptamine Receptor Subtypes

1988 • 361 citations

Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel

1986 • 315 citations

Molecular biology of the GABAA receptor: the receptor/channel superfamily

1987 • 303 citations

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1990 • 275 citations

5-HT3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line

1988 • 261 citations

Cloning and expression of the 58 kd β subunit of the inhibitory glycine receptor

1990 • 237 citations

Molecular Biology of Serotonin Receptors

1991 • 200 citations

Subtypes of Receptors for Serotonin

1990 • 199 citations

Single Subunits of the GABA _A Receptor Form Ion Channels with Properties of the Native Receptor

1988 • 193 citations

Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor.

1989 • 192 citations

1-(m-Chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist

1990 • 188 citations

5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord

1989 • 184 citations

Identification of serotonin 5-HT3 recognition sites in membranes of N1E-115 neuroblastoma cells by radioligand binding.

1988 • 149 citations

The TiPS lecture the nicotinic acetylcholine receptor: an allosteric protein prototype of ligand-gated ion channels

1990 • 133 citations

The properties of 5‐HT₃ receptors in clonal cell lines studied by patch‐clamp techniques

1989 • 129 citations

Ion permeation through 5-hydroxytryptamine-gated channels in neuroblastoma N18 cells.

1990 • 125 citations

A molecular view of neurotransmitter receptors and ionic channels.

1987 • 121 citations

Pharmacological characterization of serotonin 5-HT3 receptor-mediated electrical response in cultured mouse neuroblastoma cells

1988 • 110 citations

Molecular anatomy and molecular design of channel proteins

1990 • 104 citations

Identification of serotonin 5-HT3 recognition sites by radioligand binding in NG108-15 neuroblastoma-glioma cells

1987 • 99 citations

Biogenic amines as regulators of the proliferative activity of normal and neoplastic intestinal epithelial cells (review).

1987 • 98 citations

Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells

1988 • 83 citations

Kinetics of the membrane current mediated by serotonin 5‐HT3 receptors in cultured mouse neuroblastoma cells.

1989 • 76 citations

Characterization of [³H]Quipazine Binding to 5‐Hydroxytryptamine₃ Receptors in Rat Brain Membranes

1989 • 68 citations

Site-directed mutagenesis and single-channel currents define the ionic channel of the nicotinic acetylcholine receptor

1989 • 65 citations

Clinical evaluation of 5-HT3 receptor antagonists as anti-emetics

1991 • 61 citations

Expression of phenotypes in hybrid somatic cells derived from the nervous system.

1975 • 53 citations

Enteric receptors for 5-hydroxytryptamine

1984 • 53 citations

[3H]ICS 205-930 labels 5-HT3 recognition sites in membranes of cat and rabbit vagus nerve and superior cervical ganglion

1989 • 50 citations

Differentiation of NG108-15 cells alters channel conductance and desensitization kinetics of the 5-HT3 receptor

1991 • 35 citations

Purification of the 5-hydroxytryptamine 5-HT3 receptor from NCB20 cells.

1990 • 31 citations

[3H]zacopride binding to 5-hydroxytryptamine3 sites on partially purified rabbit enteric neuronal membranes.

1989 • 21 citations

Solubilisation of the 5‐Hydroxytryptamine₃ Receptor from Pooled Rat Cortical and Hippocampal Membranes

1990 • 18 citations