Positional Information and Pattern Formation

The chemical basis of morphogenesis

1952 • 11,233 citations

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

Diffusion in Embryogenesis

1970 • 895 citations

Pattern Regulation in Epimorphic Fields

1976 • 871 citations

Positional Information in Chick Limb Morphogenesis

1973 • 718 citations

Cytonemes

1999 • 602 citations

Morphogen Gradients: From Generation to Interpretation

2011 • 588 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

CELLULAR MOVEMENT AND CONTACT IN SEA URCHIN MORPHOGENESIS

1967 • 484 citations

The interpretation of morphogen gradients

2006 • 471 citations

Applications of a theory of biological pattern formation based on lateral inhibition

1974 • 468 citations

Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients

2014 • 464 citations

Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

2013 • 369 citations

Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism

2012 • 325 citations

Self-Enhanced Ligand Degradation Underlies Robustness of Morphogen Gradients

2003 • 292 citations

Morphogen Gradient Formation

2009 • 289 citations

A marker induction mechanism for the establishment of ordered neural mappings: its application to the retinotectal problem

1979 • 272 citations

ORIGIN OF MELANOPHORES AND THEIR RÔLE IN DEVELOPMENT OF COLOR PATTERNS IN VERTEBRATES

1948 • 261 citations

Thresholds in development

1977 • 247 citations

Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate

2012 • 245 citations

Morphogen transport

2013 • 245 citations

Cytoneme-Mediated Contact-Dependent Transport of the Drosophila Decapentaplegic Signaling Protein

2014 • 215 citations

The number of polarizing region cells required to specify additional digits in the developing chick wing

1981 • 209 citations

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

2010 • 197 citations

A model of pattern formation in insect embryogenesis

1977 • 154 citations

Coordination of Patterning and Growth by the Morphogen DPP

2014 • 152 citations

Scaling of morphogen gradients by an expansion-repression integral feedback control

2010 • 151 citations

A System of Repressor Gradients Spatially Organizes the Boundaries of Bicoid-Dependent Target Genes

2012 • 147 citations

Specifying Positional Information in the Embryo: Looking Beyond Morphogens

2007 • 146 citations

Pattern formation and determination in the antenna of the homoeotic mutant Antennapedia of Drosophila melanogaster

1971 • 138 citations

Space-dependent cell determination under the control of a morphogen gradient

1978 • 127 citations

Interkalare Regeneration und segmentale Gradienten bei den Extremit�ten vonLeucophaea-Larven (Blattaria)

1970 • 126 citations

Positional information and patterning revisited

2010 • 121 citations

Polarity and Patterns in the Postembryonic Development of Insects

1970 • 113 citations

The principle of non-equivalence in development

1976 • 112 citations

Positional Information and Positional Signalling in Hydra

1974 • 110 citations

A morphogenetic trigger: is there an emerging concept in plant developmental biology?

2009 • 108 citations

Construction of a Vertebrate Embryo from Two Opposing Morphogen Gradients

2014 • 106 citations

The effect of cell killing by X-irradiation on pattern formation in the chick limb

1979 • 105 citations

A plausible mechanism for auxin patterning along the developing root

2010 • 99 citations

Models for the Generation and Interpretation of Gradients

2009 • 94 citations

Morphogen interpretation: the transcriptional logic of neural tube patterning

2013 • 94 citations

Positional identity of adult stem cells in salamander limb regeneration

2007 • 85 citations

Positional Signalling along Hydra

1972 • 80 citations

Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo

2013 • 80 citations

Positional Information Is Reprogrammed in Blastema Cells of the Regenerating Limb of the Axolotl (Ambystoma mexicanum)

2013 • 80 citations

Single cells can sense their position in a morphogen gradient

1999 • 77 citations

Gradients of signalling in the developing limb

2011 • 72 citations

A reevaluation of X-irradiation-induced phocomelia and proximodistal limb patterning

2009 • 66 citations

Pattern Formation by Graded and Uniform Signals in the Early Drosophila Embryo

2012 • 62 citations

The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands

2013 • 61 citations

Attenuation of positional signalling in the chick limb by high doses of γ-radiation

1978 • 58 citations

Transcriptional components of anteroposterior positional information during zebrafish fin regeneration

2013 • 57 citations

Positional signal transmission in the developing chick limb

1981 • 55 citations

Developmental patterning by gradients of mobile small RNAs

2014 • 53 citations

Mechanisms underlying vertebrate limb regeneration: lessons from the salamander

2014 • 52 citations

Self-organization phenomena resulting from cell-cell contact

1977 • 52 citations

Generation and interpretation of FGF morphogen gradients in vertebrates

2013 • 47 citations

Gradients and the Specification of Planar Polarity in the Insect Cuticle

2009 • 44 citations

Directive versus permissive induction: a working hypothesis.

1977 • 44 citations

The Emergence and Regulation of Spatial Organization in Early Animal Development

1975 • 38 citations

Covalent modification of proteins as a threshold mechanism in development

1990 • 23 citations

Mechanical forces as information: an integrated approach to plant and animal development

2014 • 21 citations

Limb Patterning: From Signaling Gradients to Molecular Oscillations

2013 • 18 citations

Nonsegmental organization of positional information in regenerating Ambystoma limbs

1981 • 11 citations

Morphogen Gradients: Limits to Signaling or Limits to Measurement?

2010 • 11 citations

Robustness of Morphogen gradients with "bucket brigade" transport through membrane-associated non-receptors

2013 • 10 citations