Models for the Generation and Interpretation of Gradients

The chemical basis of morphogenesis

1952 • 11,233 citations

A theory of biological pattern formation

1972 • 3,055 citations

Models of biological pattern formation

1982 • 1,851 citations

Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

2004 • 970 citations

Polycomb silencing mechanisms and the management of genomic programmes

2006 • 847 citations

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

1997 • 836 citations

WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

2000 • 584 citations

Forging patterns and making waves from biology to geology: a commentary on Turing (1952) ‘The chemical basis of morphogenesis’

2015 • 566 citations

A morphogen gradient of Wnt/β-catenin signalling regulates anteroposterior neural patterning inXenopus

2001 • 504 citations

Regeneration of Hydra from Reaggregated Cells

1972 • 459 citations

Polycomb/Trithorax response elements and epigenetic memory of cell identity

2006 • 450 citations

Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.

1993 • 449 citations

β-Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis

2007 • 445 citations

Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development

1996 • 440 citations

Compartments and their boundaries in vertebrate brain development

2005 • 397 citations

THE MECHANICS OF SEA URCHIN DEVELOPMENT, STUDIED BY OPERATIVE METHODS

1939 • 388 citations

Smed- β catenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration

2007 • 355 citations

Nodal and BMP2/4 Signaling Organizes the Oral-Aboral Axis of the Sea Urchin Embryo

2004 • 353 citations

Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus

1997 • 332 citations

Experiments on the development of the fore limb of Amblystoma, a self‐differentiating equipotential system

1918 • 330 citations

Initiation of Rhombomeric Hoxb4 Expression Requires Induction by Somites and a Retinoid Pathway

1998 • 275 citations

Progressive induction of caudal neural character by graded Wnt signaling

2002 • 272 citations

Cell determination boundaries as organizing regions for secondary embryonic fields

1983 • 267 citations

The formation of the mesoderm in urodelean amphibians

1973 • 247 citations

Regulation of ADMP and BMP2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field

2005 • 247 citations

On relations of symmetry in transplanted limbs

1921 • 239 citations

Autoregulation of a drosophila homeotic selector gene

1988 • 229 citations

Models of Biological Pattern Formation: From Elementary Steps to the Organization of Embryonic Axes

2007 • 208 citations

Silencing ofSmed-βcatenin1generates radial-like hypercephalized planarians

2008 • 203 citations

Generation of Robust Left-Right Asymmetry in the Mouse Embryo Requires a Self-Enhancement and Lateral-Inhibition System

2006 • 200 citations

Models and Hypotheses

1976 • 181 citations

Activation and organization of the central nervous system in amphibians. Part III. Synthesis of a new working hypothesis

1952 • 180 citations

The Chemical Basis of Morphogenesis

2020 • 175 citations

Lefty Proteins Are Long-Range Inhibitors of Squint-Mediated Nodal Signaling

2002 • 162 citations

A Model for Pattern Formation of Hypostome, Tentacles, and Foot in Hydra: How to Form Structures Close to Each Other, How to Form Them at a Distance

1993 • 162 citations

Vertebrate Limb Development: Moving from Classical Morphogen Gradients to an Integrated 4-Dimensional Patterning System

2009 • 151 citations

Direct and continuous assessment by cells of their position in a morphogen gradient

1995 • 150 citations

Brain segmentation and forebrain development in amniotes

2001 • 150 citations

Anti-Dorsalizing Morphogenetic Protein is a novel TGF-β homolog expressed in the Spemann organizer

1995 • 145 citations

Twotcf3genes cooperate to pattern the zebrafish brain

2003 • 145 citations

A boundary model for pattern formation in vertebrate limbs

1983 • 134 citations

Space-dependent cell determination under the control of a morphogen gradient

1978 • 127 citations

Axis-inducing activities and cell fates of the zebrafish organizer

2000 • 108 citations

Initiation of the proximodistal axis in insect legs

1995 • 107 citations

High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene.

1991 • 99 citations

Gradients in Planarian Regeneration and Homeostasis

2009 • 98 citations

The radial‐symmetric hydra and the evolution of the bilateral body plan: an old body became a young brain

2002 • 94 citations

Self-Regulatory Circuits in Dorsoventral Axis Formation of the Short-Germ Beetle Tribolium castaneum

2008 • 89 citations

Organizer and axes formation as a self-organizing process.

2001 • 86 citations

Robust Generation and Decoding of Morphogen Gradients

2009 • 84 citations

Feedback Inhibition of JAK/STAT Signaling by Apontic Is Required to Limit an Invasive Cell Population

2008 • 79 citations

Chapter 2 Biological Features and Physical Concepts of Pattern Formation Exemplified By Hydra

1977 • 72 citations

Physical aspects of tissue evagination and biological form

1977 • 71 citations

Defined concentrations of a posteriorizing signal are critical for MafB/Kreisler segmental expression in the hindbrain

1998 • 70 citations

Do vertebrate neural crest and cranial placodes have a common evolutionary origin?

2008 • 70 citations

Development of the two-part pattern during regeneration of the head in hydra

1988 • 69 citations

Axial Patterning in Hydra

2009 • 64 citations

Different strategies for midline formation in bilaterians

2004 • 60 citations

Zebrafish admp is required to restrict the size of the organizer and to promote posterior and ventral development

2001 • 55 citations

Primary body axes of vertebrates: Generation of a near‐Cartesian coordinate system and the role of Spemann‐type organizer

2006 • 53 citations

Cooperative Action of ADMP- and BMP-Mediated Pathways in Regulating Cell Fates in the Zebrafish Gastrula

2002 • 47 citations

De novo induction of the organizer and formation of the primitive streak in an experimental model of notochord reconstitution in avian embryos

1998 • 45 citations

Specification of midbrain territory

2004 • 45 citations

Why thumbs are up

1995 • 35 citations

The formation of the mesoderm in urodelean amphibians VI. The self-organizing capacity of the induced meso-endoderm

1992 • 35 citations

Systems Biology of the Self-regulating Morphogenetic Gradient of the Xenopus Gastrula

2009 • 33 citations

Pattern triplications produced by a cell-lethal mutation in Drosophila

1981 • 29 citations

Progressive induction of caudal neural character by graded Wnt signaling

2002 • 26 citations

Cooperation of Compartments for the Generation of Positional Information

1980 • 24 citations