Positional information and patterning revisited

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

Diffusion in Embryogenesis

1970 • 895 citations

Pattern Regulation in Epimorphic Fields

1976 • 871 citations

Morphogen gradient interpretation

2001 • 738 citations

Positional Information in Chick Limb Morphogenesis

1973 • 718 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

A morphogen gradient of Wnt/β-catenin signalling regulates anteroposterior neural patterning inXenopus

2001 • 504 citations

The interpretation of morphogen gradients

2006 • 471 citations

Kinetics of Morphogen Gradient Formation

2007 • 398 citations

Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules

2009 • 367 citations

Shaping Morphogen Gradients by Proteoglycans

2009 • 338 citations

Morpheus Unbound: Reimagining the Morphogen Gradient

2007 • 329 citations

Self-Enhanced Ligand Degradation Underlies Robustness of Morphogen Gradients

2003 • 292 citations

Morphogen Gradient Formation

2009 • 289 citations

On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes

2010 • 255 citations

Signaling Gradients during Paraxial Mesoderm Development

2009 • 253 citations

Thresholds in development

1977 • 247 citations

Scaling of the BMP activation gradient in Xenopus embryos

2008 • 230 citations

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

2010 • 197 citations

Growing models of vertebrate limb development

2008 • 174 citations

A Model for Pattern Formation of Hypostome, Tentacles, and Foot in Hydra: How to Form Structures Close to Each Other, How to Form Them at a Distance

1993 • 162 citations

Modelling the Bicoid gradient

2010 • 157 citations

Scaling of morphogen gradients by an expansion-repression integral feedback control

2010 • 151 citations

Direct and continuous assessment by cells of their position in a morphogen gradient

1995 • 150 citations

Specifying Positional Information in the Embryo: Looking Beyond Morphogens

2007 • 146 citations

Making digit patterns in the vertebrate limb

2005 • 140 citations

Control of Dpp morphogen signalling by a secreted feedback regulator

2010 • 136 citations

A boundary model for pattern formation in vertebrate limbs

1983 • 134 citations

Regulative feedback in pattern formation: towards a general relativistic theory of positional information

2008 • 110 citations

A morphogenetic trigger: is there an emerging concept in plant developmental biology?

2009 • 108 citations

The Core Protein of Glypican Dally-Like Determines Its Biphasic Activity in Wingless Morphogen Signaling

2009 • 107 citations

A plausible mechanism for auxin patterning along the developing root

2010 • 99 citations

Models for the Generation and Interpretation of Gradients

2009 • 94 citations

Positional information and pattern regulation in regeneration of hydra.

1971 • 87 citations

Extracellular regulation of BMP signaling

2010 • 86 citations

The Measure of Success: Constraints, Objectives, and Tradeoffs in Morphogen-mediated Patterning

2009 • 86 citations

Visualisation and Quantification of Morphogen Gradient Formation in the Zebrafish

2009 • 85 citations

Positional identity of adult stem cells in salamander limb regeneration

2007 • 85 citations

Robust Generation and Decoding of Morphogen Gradients

2009 • 84 citations

Establishment and maintenance of planar epithelial cell polarity by asymmetric cadherin bridges: A computer model

2005 • 83 citations

Integrating positional information at the level of Smad1/5/8

2008 • 80 citations

Positional Signalling along Hydra

1972 • 80 citations

Temporal dynamics of patterning by morphogen gradients

2009 • 73 citations

Axial Patterning in Hydra

2009 • 64 citations

Interpretation of the Wingless Gradient Requires Signaling-Induced Self-Inhibition

2009 • 55 citations

Evolutionary shifts of vertebrate structures and Hox expression up and down the axial series of segments: a consideration of possible mechanisms.

2000 • 52 citations

Theoretical and experimental approaches to understand morphogen gradients

2008 • 50 citations

Morphogen profiles can be optimized to buffer against noise

2009 • 46 citations

Systems Biology of the Self-regulating Morphogenetic Gradient of the Xenopus Gastrula

2009 • 33 citations

When it pays to rush: interpreting morphogen gradients prior to steady-state

2009 • 31 citations

Forming and Interpreting Gradients in the Early Xenopus Embryo

2009 • 29 citations

Establishment and maintenance.

1955 • 28 citations

Robustness of positional specification by the Hedgehog morphogen gradient

2010 • 24 citations

Covalent modification of proteins as a threshold mechanism in development

1990 • 23 citations

Understanding how morphogens work

2008 • 23 citations

Mathematical Model of the Formation of Morphogen Gradients Through Membrane-Associated Non-receptors

2009 • 21 citations

Nonsegmental organization of positional information in regenerating Ambystoma limbs

1981 • 11 citations

Morphogen Gradients: Limits to Signaling or Limits to Measurement?

2010 • 11 citations

Establishing positional information through gradient dynamics

2010 • 4 citations

Deleted Work

1955 • 0 citations