The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands

The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)

1995 • 6,935 citations

Effective targeted gene ‘knockdown’ in zebrafish

2000 • 2,464 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

TGFβ–SMAD signal transduction: molecular specificity and functional flexibility

2007 • 1,199 citations

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

1997 • 1,098 citations

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

2002 • 1,088 citations

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

2007 • 975 citations

Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter

2002 • 849 citations

A Transposon-Mediated Gene Trap Approach Identifies Developmentally Regulated Genes in Zebrafish

2004 • 833 citations

The regulation of TGFβ signal transduction

2009 • 788 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning

1997 • 518 citations

Functional Dissection of the Tol2 Transposable Element Identified the Minimal cis-Sequence and a Highly Repetitive Sequence in the Subterminal Region Essential for Transposition

2006 • 511 citations

Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish

1993 • 458 citations

Dpp Gradient Formation in the Drosophila Wing Imaginal Disc

2000 • 453 citations

Ventral and Lateral Regions of the Zebrafish Gastrula, Including the Neural Crest Progenitors, Are Established by abmp2b/swirlPathway of Genes

1998 • 424 citations

Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes

1996 • 408 citations

Shaping Morphogen Gradients by Proteoglycans

2009 • 338 citations

Shaping BMP morphogen gradients in theDrosophilaembryo and pupal wing

2005 • 288 citations

A Transgenic Lef1/β-Catenin-Dependent Reporter Is Expressed in Spatially Restricted Domains throughout Zebrafish Development

2002 • 285 citations

Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation

2000 • 269 citations

Transforming Growth Factor β-Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

2008 • 257 citations

Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

2009 • 240 citations

Scaling of the BMP activation gradient in Xenopus embryos

2008 • 230 citations

Zebrafish ΔNp63 Is a Direct Target of Bmp Signaling and Encodes a Transcriptional Repressor Blocking Neural Specification in the Ventral Ectoderm

2002 • 221 citations

The BMP Signaling Gradient Patterns Dorsoventral Tissues in a Temporally Progressive Manner along the Anteroposterior Axis

2008 • 214 citations

Differential Regulation ofchordinExpression Domains in Mutant Zebrafish

1997 • 210 citations

Fgf signalling controls the dorsoventral patterning of the zebrafish embryo

2004 • 198 citations

Maternal and Zygotic Control of Zebrafish Dorsoventral Axial Patterning

2011 • 186 citations

TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch

2008 • 164 citations

Two-color fluorescent in situ hybridization in the embryonic zebrafish brain using differential detection systems

2011 • 164 citations

One for All—A Highly Efficient and Versatile Method for Fluorescent Immunostaining in Fish Embryos

2011 • 157 citations

Zebrafish Bmp4 regulates left–right asymmetry at two distinct developmental time points

2007 • 155 citations

The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo

2001 • 153 citations

Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development

2005 • 143 citations

Double in Situ Hybridization Techniques in Zebrafish

2001 • 140 citations

Signalling by TGF-β family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin

1996 • 132 citations

Positional information and patterning revisited

2010 • 121 citations

Multicolor fluorescent in situ hybridization to define abutting and overlapping gene expression in the embryonic zebrafish brain

2011 • 121 citations

Transforming Growth Factor β Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

2009 • 121 citations

Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity

2006 • 116 citations

Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton

2011 • 101 citations

Transforming Growth Factor β Inhibits Bone Morphogenetic Protein-Induced Transcription through Novel Phosphorylated Smad1/5-Smad3 Complexes

2012 • 92 citations

Dynamic smad‐mediated BMP signaling revealed through transgenic zebrafish

2011 • 89 citations

Spatial regulation of BMP activity

2012 • 88 citations

Sustained Bmp signaling is essential for cloaca development in zebrafish

2006 • 88 citations

Lumenal Transmission of Decapentaplegic in Drosophila Imaginal Discs

2002 • 87 citations

bozozokdirectly repressesbmp2btranscription and mediates the earliest dorsoventral asymmetry ofbmp2bexpression in zebrafish

2003 • 82 citations

The nieuwkoid/dharma Homeobox Gene Is Essential for bmp2b Repression in the Zebrafish Pregastrula

1999 • 82 citations

Formation of the Long Range Dpp Morphogen Gradient

2011 • 80 citations

The nieuwkoid gene characterizes and mediates a Nieuwkoop-center-like activity in the zebrafish

1998 • 80 citations

Dorsoventral Patterning in the Zebrafish: Bone Morphogenetic Proteins and Beyond

2002 • 76 citations

In vivo analysis using variants of zebrafish BMPR-IA: range of action and involvement of BMP in ectoderm patterning

1999 • 72 citations

Real time monitoring of BMP Smads transcriptional activity during mouse development

2008 • 72 citations

Maternal induction of ventral fate by zebrafish radar

2003 • 70 citations

Zebrafish bmp4 functions during late gastrulation to specify ventroposterior cell fates

2007 • 70 citations

Gdf6a is required for the initiation of dorsal–ventral retinal patterning and lens development

2009 • 69 citations

Spindle Position in Symmetric Cell Divisions during Epiboly Is Controlled by Opposing and Dynamic Apicobasal Forces

2012 • 65 citations

Cancer-Associated Transforming Growth Factor β Type II Receptor Gene Mutant Causes Activation of Bone Morphogenic Protein-Smads and Invasive Phenotype

2008 • 61 citations

Intersegmental vessel formation in zebrafish: requirement for VEGF but not BMP signalling revealed by selective and non‐selective BMP antagonists

2010 • 59 citations

Dynamic analysis of BMP‐responsive smad activity in live zebrafish embryos

2011 • 51 citations

FGF signaling is required for β-catenin-mediated induction of the zebrafish organizer

2006 • 51 citations

The Decapentaplegic morphogen gradient: a precise definition

2008 • 48 citations

SNW1 Is a Critical Regulator of Spatial BMP Activity, Neural Plate Border Formation, and Neural Crest Specification in Vertebrate Embryos

2011 • 44 citations

Bmp inhibition is necessary for post-gastrulation patterning and morphogenesis of the zebrafish tailbud

2009 • 42 citations

In vivo imaging reveals a role for Cdc42 in spindle positioning and planar orientation of cell divisions during vertebrate neural tube closure

2009 • 42 citations

BMP regulation of myogenesis in zebrafish

2010 • 40 citations

SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling

2010 • 39 citations

Visualization of Gli Activity in Craniofacial Tissues of Hedgehog-Pathway Reporter Transgenic Zebrafish

2010 • 39 citations

Morphogenesis and Cell Fate Determination within the Adaxial Cell Equivalence Group of the Zebrafish Myotome

2012 • 36 citations

Regulation of BMP activity and range in Drosophila wing development

2011 • 36 citations

The ventralizing activity of Radar, a maternally expressed bone morphogenetic protein, reveals complex bone morphogenetic protein interactions controlling dorso-ventral patterning in zebrafish

2000 • 36 citations

Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutations

2001 • 34 citations

Tailbud-derived Bmp4 drives proliferation and inhibits maturation of zebrafish chordamesoderm

2008 • 32 citations

SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo

2010 • 24 citations

Formation and maintenance of morphogen gradients: An essential role for the endomembrane system inDrosophila melanogasterwing development

2011 • 12 citations