Morphogen interpretation: the transcriptional logic of neural tube patterning

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube

2000 • 1,077 citations

Hedgehog Signaling in Development and Cancer

2008 • 1,013 citations

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

2008 • 714 citations

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

2000 • 704 citations

Coordinate Regulation of Motor Neuron Subtype Identity and Pan-Neuronal Properties by the bHLH Repressor Olig2

2001 • 614 citations

Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

2007 • 602 citations

Emerging properties of animal gene regulatory networks

2010 • 564 citations

THE SPECIFICATION OF DORSAL CELL FATES IN THE VERTEBRATE CENTRAL NERVOUS SYSTEM

1999 • 536 citations

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

1998 • 497 citations

Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

2012 • 452 citations

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

1998 • 448 citations

Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

2000 • 394 citations

Shadow Enhancers Foster Robustness of Drosophila Gastrulation

2010 • 392 citations

Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube.

1997 • 323 citations

SnapShot: Spinal Cord Development

2011 • 321 citations

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

2002 • 313 citations

SOX genes and neural progenitor identity

2005 • 310 citations

Canalization of Gene Expression in the Drosophila Blastoderm by Gap Gene Cross Regulation

2009 • 293 citations

Different Levels of Repressor Activity Assign Redundant and Specific Roles to Nkx6 Genes in Motor Neuron and Interneuron Specification

2001 • 256 citations

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

2008 • 239 citations

Gli proteins and the control of spinal‐cord patterning

2003 • 226 citations

The role of binding site cluster strength in Bicoid-dependent patterning in Drosophila

2005 • 177 citations

Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning

2012 • 174 citations

A System of Repressor Gradients Spatially Organizes the Boundaries of Bicoid-Dependent Target Genes

2012 • 147 citations

Mechanistic Differences in the Transcriptional Interpretation of Local and Long-Range Shh Morphogen Signaling

2012 • 140 citations

Dorsal-Ventral Gene Expression in the Drosophila Embryo Reflects the Dynamics and Precision of the Dorsal Nuclear Gradient

2012 • 114 citations

The cis-Regulatory Logic of Hedgehog Gradient Responses: Key Roles for Gli Binding Affinity, Competition, and Cooperativity

2011 • 105 citations

Noise drives sharpening of gene expression boundaries in the zebrafish hindbrain

2012 • 91 citations

A gene regulatory motif that generates oscillatory or multiway switch outputs

2012 • 75 citations

Gradients of signalling in the developing limb

2011 • 72 citations

Pattern Formation by Graded and Uniform Signals in the Early Drosophila Embryo

2012 • 62 citations

Temporal dynamics, spatial range, and transcriptional interpretation of the Dorsal morphogen gradient

2012 • 51 citations