Specifying Positional Information in the Embryo: Looking Beyond Morphogens

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Principles of Development

2019 • 1,040 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

2004 • 970 citations

Diffusion in Embryogenesis

1970 • 895 citations

Morphogen gradient interpretation

2001 • 738 citations

Probing the Limits to Positional Information

2007 • 698 citations

Lipoprotein particles are required for Hedgehog and Wingless signalling

2005 • 678 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Dynamic control of positional information in the early Drosophila embryo

2004 • 577 citations

Stability and Nuclear Dynamics of the Bicoid Morphogen Gradient

2007 • 510 citations

Establishment of developmental precision and proportions in the early Drosophila embryo

2002 • 496 citations

Dpp Gradient Formation in the Drosophila Wing Imaginal Disc

2000 • 453 citations

Do Morphogen Gradients Arise by Diffusion?

2002 • 403 citations

A Hedgehog-Insensitive Form of Patched Provides Evidence for Direct Long-Range Morphogen Activity of Sonic Hedgehog in the Neural Tube

2001 • 364 citations

Fidelity in planar cell polarity signalling

2003 • 320 citations

Facilitated Transport of a Dpp/Scw Heterodimer by Sog/Tsg Leads to Robust Patterning of the Drosophila Blastoderm Embryo

2005 • 291 citations

Shaping BMP morphogen gradients in theDrosophilaembryo and pupal wing

2005 • 288 citations

A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

2005 • 270 citations

Mesodermal patterning by an inducer gradient depends on secondary cell–cell communication

1994 • 267 citations

Patterning Systems—From One End of the Limb to the Other

2003 • 224 citations

Drosophilaglypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc

2005 • 216 citations

Coupling segmentation to axis formation

2004 • 211 citations

Regulation of Cell Proliferation by a Morphogen Gradient

2005 • 209 citations

Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic

2005 • 205 citations

Mechanisms for Positional Signalling by Morphogen Transport: a Theoretical Study

1998 • 181 citations

Cell interactions and planar polarity in the abdominal epidermis ofDrosophila

2004 • 166 citations

Regulatory Principles of Developmental Signaling

2002 • 155 citations

Space-dependent cell determination under the control of a morphogen gradient

1978 • 127 citations

Incredible journey: how do developmental signals travel through tissue?

2004 • 115 citations

Short-Range Signaling by Candidate Morphogens of the TGFβ Family and Evidence for a Relay Mechanism of Induction

1996 • 104 citations

Establishment and maintenance of planar epithelial cell polarity by asymmetric cadherin bridges: A computer model

2005 • 83 citations

Visualizing Long-Range Movement of the Morphogen Xnr2 in the Xenopus Embryo

2004 • 71 citations

Activin redux: specification of mesodermal pattern inXenopusby graded concentrations of endogenous activin B

2004 • 57 citations

Control of growth and positional information by the graded vestigial expression pattern in the wing of Drosophila melanogaster

2006 • 57 citations

Refinement of gene expression patterns in the earlyXenopusembryo

2004 • 53 citations

Noise, delays, robustness, canalization and all that

2004 • 38 citations

New “Hogs” in Hedgehog Transport and Signal Reception

2006 • 22 citations