A System of Repressor Gradients Spatially Organizes the Boundaries of Bicoid-Dependent Target Genes

The chemical basis of morphogenesis

1952 • 11,233 citations

An optimized transgenesis system for Drosophila using germ-line-specific φC31 integrases

2007 • 1,874 citations

Quantifying similarity between motifs

2007 • 1,805 citations

The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

1988 • 1,022 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

1989 • 672 citations

The gradient morphogen bicoid is a concentration-dependent transcriptional activator

1989 • 655 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

1996 • 629 citations

Morphogen Gradients: From Generation to Interpretation

2011 • 588 citations

Establishment of developmental precision and proportions in the early Drosophila embryo

2002 • 496 citations

Predicting expression patterns from regulatory sequence in Drosophila segmentation

2008 • 495 citations

Transcription Factors Bind Thousands of Active and Inactive Regions in the Drosophila Blastoderm

2008 • 495 citations

The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila

2008 • 483 citations

Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

2012 • 452 citations

The Decapentaplegic morphogen gradient: from pattern formation to growth regulation

2007 • 377 citations

Multiplex Detection of RNA Expression in Drosophila Embryos

2004 • 367 citations

Site-Specific Transformation of Drosophila via ϕC31 Integrase-Mediated Cassette Exchange

2006 • 361 citations

Transcriptional regulation of a pair-rule stripe in Drosophila.

1991 • 354 citations

Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen

1993 • 322 citations

Regulation of a Segmentation Stripe by Overlapping Activators and Repressors in the Drosophila Embryo

1991 • 321 citations

Transducing the Dpp Morphogen Gradient in the Wing of Drosophila

1999 • 280 citations

Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function

2011 • 277 citations

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

2007 • 272 citations

One hundred years of positional information

1996 • 269 citations

Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins

1998 • 266 citations

The Drosophila Gene brinker Reveals a Novel Mechanism of Dpp Target Gene Regulation

1999 • 262 citations

brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes

1999 • 232 citations

Relief of gene repression by Torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning

2000 • 231 citations

Borders of parasegments in Drosophila embryos are delimited by the fushi tarazu and even-skipped genes

1987 • 230 citations

Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1

2004 • 223 citations

Conversion of an Extracellular Dpp/BMP Morphogen Gradient into an Inverse Transcriptional Gradient

2003 • 181 citations

The Formation of the Bicoid Morphogen Gradient Requires Protein Movement from Anteriorly Localized mRNA

2011 • 178 citations

The role of binding site cluster strength in Bicoid-dependent patterning in Drosophila

2005 • 177 citations

Homotypic Regulatory Clusters in Drosophila

2003 • 168 citations

A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system

2008 • 167 citations

Isolation of the Drosophila segmentation gene runt and analysis of its expression during embryogenesis.

1988 • 135 citations

How the Dorsal gradient works: Insights from postgenome technologies

2008 • 132 citations

cis-acting control elements for Krüppel expression in the Drosophila embryo.

1990 • 120 citations

Down-regulation of the Drosophila morphogen bicoid by the torso receptor-mediated signal transduction cascade

1993 • 116 citations

Sequence specificity of the core-binding factor

1993 • 108 citations

Cells’ Perception of Position in a Concentration Gradient

1998 • 107 citations

The localized requirements for a gene affecting segmentation in Drosophila: Analysis of larvae mosaic for runt

1985 • 106 citations

The value of position-specific priors in motif discovery using MEME

2010 • 106 citations

Capicua DNA-binding sites are general response elements for RTK signaling inDrosophila

2011 • 105 citations

Drosophila embryonic pattern repair: how embryos respond to bicoid dosage alteration

1997 • 102 citations

Anterior-posterior positional information in the absence of a strong Bicoid gradient

2009 • 97 citations

Capicua Regulates Cell Proliferation Downstream of the Receptor Tyrosine Kinase/Ras Signaling Pathway

2007 • 94 citations

Targeting gene expression to the head: the Drosophila orthodenticle gene is a direct target of the Bicoid morphogen

1998 • 86 citations

NEW EMBO MEMBER'S REVIEW: In and out of Torso RTK signalling

2003 • 85 citations

Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains

2009 • 76 citations

Gap gene properties of the pair-rule gene runt during Drosophila segmentation

1994 • 76 citations

Two distinct mechanisms for differential positioning of gene expression borders involving the Drosophila gap protein giant

1998 • 68 citations

orthodenticle regulation during embryonic head development in Drosophila

1996 • 63 citations

Precise Registration of Gene Expression Boundaries by a Repressive Morphogen in Drosophila

2008 • 58 citations

Stubb: a program for discovery and analysis of cis-regulatory modules

2006 • 56 citations

Gene Regulation by MAPK Substrate Competition

2011 • 56 citations

Combinatorial activation and concentration-dependent repression of the Drosophila even skipped stripe 3+7 enhancer

2011 • 53 citations

Groucho-dependent repression by Sloppy-paired 1 differentially positions anterior pair-rule stripes in the Drosophila embryo

2004 • 52 citations

Statistical tests to compare motif count exceptionalities

2007 • 36 citations

[10] In Vivo analysis of lacZ fusion genes in transgenic Drosophila melanogaster

2000 • 24 citations