Limb Patterning: From Signaling Gradients to Molecular Oscillations

Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

2004 • 970 citations

Avian hairy Gene Expression Identifies a Molecular Clock Linked to Vertebrate Segmentation and Somitogenesis

1997 • 954 citations

Positional Information in Chick Limb Morphogenesis

1973 • 718 citations

Functions of FGF signalling from the apical ectodermal ridge in limb development

2002 • 554 citations

Dynamic Changes in the Response of Cells to Positive Hedgehog Signaling during Mouse Limb Patterning

2004 • 498 citations

Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

2012 • 452 citations

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

2003 • 379 citations

Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning

2008 • 362 citations

Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes

2000 • 314 citations

A re-examination of proximodistal patterning during vertebrate limb development

2002 • 297 citations

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

2008 • 289 citations

Rethinking the proximodistal axis of the vertebrate limb in the molecular era

2007 • 262 citations

MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb

2003 • 257 citations

Signaling Gradients during Paraxial Mesoderm Development

2009 • 253 citations

Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling

2002 • 237 citations

Vertebrate Limb Development

1994 • 204 citations

Mouse GLI3 Regulates Fgf8 Expression and Apoptosis in the Developing Neural Tube, Face, and Limb Bud

2002 • 204 citations

A Self-Regulatory System of Interlinked Signaling Feedback Loops Controls Mouse Limb Patterning

2009 • 191 citations

The Initiation and Propagation of Hes7 Oscillation Are Cooperatively Regulated by Fgf and Notch Signaling in the Somite Segmentation Clock

2007 • 187 citations

Retinoic Acid Promotes Limb Induction through Effects on Body Axis Extension but Is Unnecessary for Limb Patterning

2009 • 164 citations

Initiation of Proximal-Distal Patterning in the Vertebrate Limb by Signals and Growth

2011 • 157 citations

Diffusible Signals, Not Autonomous Mechanisms, Determine the Main Proximodistal Limb Subdivision

2011 • 143 citations

Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb

2007 • 131 citations

SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling

2011 • 110 citations

GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis

2012 • 103 citations

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

2007 • 103 citations

Retinoic Acid Synthesis Controlled by Raldh2 Is Required Early for Limb Bud Initiation and Then Later as a Proximodistal Signal during Apical Ectodermal Ridge Formation

2004 • 99 citations

Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development

2005 • 97 citations

The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord

2003 • 89 citations

A gene regulatory motif that generates oscillatory or multiway switch outputs

2012 • 75 citations

Gradients of signalling in the developing limb

2011 • 72 citations

Sonic hedgehog in temporal control of somite formation

2010 • 67 citations

Specification of cell fate along the proximal-distal axis in the developing chick limb bud

2007 • 64 citations

Retinoic Acid Repression of Bone Morphogenetic Protein 4 in Inner Ear Development

2003 • 62 citations

Levels of Gli3 repressor correlate withBmp4expression and apoptosis during limb development

2004 • 61 citations

A Molecular Clock Operates During Chick Autopod Proximal-distal Outgrowth

2007 • 60 citations

Ultradian Oscillations in Notch Signaling Regulate Dynamic Biological Events

2010 • 57 citations

Retinoic acid inhibits BMP4-induced C3H10T1/2 stem cell commitment to adipocyte via downregulating Smad/p38MAPK signaling

2011 • 30 citations

The Sonic hedgehog gradient in the developing limb

2012 • 26 citations

The Synchrony and Cyclicity of Developmental Events

2012 • 15 citations

Joint interpretation of AER/FGF and ZPA/SHH over time and space underlies hairy2 expression in the chick limb

2012 • 14 citations

Watch-ing out for chick limb development

2007 • 6 citations

Retinoic acid signaling regulates embryonic clock hairy2 gene expression in the developing chick limb

2012 • 6 citations