Immunotherapy of allergic bronchopulmonary aspergillosis a clinical and experimental approach

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2000 • 6,348 citations

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1999 • 3,351 citations

Aspergillus fumigatusand Aspergillosis

1999 • 2,249 citations

Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy

1999 • 1,100 citations

Practice Guidelines for Diseases Caused by Aspergillus

2000 • 806 citations

Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six‐year follow‐up study.

2001 • 545 citations

Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation

2001 • 522 citations

Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom☆☆☆★★★

1998 • 458 citations

Activation of CD25+CD4+ Regulatory T Cells by Oral Antigen Administration

2001 • 458 citations

CD4+ and CD8+ anergic T cells induced by interleukin-10–treated human dendritic cells display antigen-specific suppressor activity

2002 • 455 citations

Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity

2000 • 394 citations

A Controlled Trial of Immunotherapy for Asthma in Allergic Children

1997 • 349 citations

Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production

2000 • 343 citations

Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia.

1994 • 309 citations

An Overview of Fungal Infections

2001 • 283 citations

Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages

1997 • 283 citations

Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study

2001 • 282 citations

Allergic bronchopulmonary aspergillosis in cystic fibrosis

1984 • 273 citations

Double-blind, placebo-controlled rush immunotherapy with a standardized Alternaria extract

1990 • 251 citations

Molecular and cellular mechanisms of allergic disease☆☆☆

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Involvement of CD14 and Toll-Like Receptors in Activation of Human Monocytes byAspergillus fumigatusHyphae

2001 • 227 citations

The human mast cell: functions in physiology and disease

2001 • 198 citations

Bee venom immunotherapy induces a shift in cytokine responses from a TH‐2 to a TH‐1 dominant pattern: comparison of rush and conventional immunotherapy

1995 • 191 citations

Comparison of the efficacy of subcutaneous and sublingual immunotherapy in mite-sensitive patients with rhinitis and asthma—a placebo controlled study

1999 • 182 citations

Clinical aspects of chronic granulomatous disease

2001 • 180 citations

Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy

2001 • 174 citations

Allergen-Derived T Cell Peptide-Induced Late Asthmatic Reactions Precede the Induction of Antigen-Specific Hyporesponsiveness in Atopic Allergic Asthmatic Subjects

2001 • 172 citations

Efficacy of sublingual immunotherapy in children with asthma and rhinitis: A double‐blind, placebo‐controlled study

2001 • 170 citations

Selected recombinant Aspergillus fumigatus allergens bind specifically to IgE in ABPA

2000 • 160 citations

Proteases fromAspergillus fumigatusInduce Interleukin (IL)–6 and IL‐8 Production in Airway Epithelial Cell Lines by Transcriptional Mechanisms

1999 • 143 citations

CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma☆☆☆★

1999 • 136 citations

Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes TH1 cytokine expression while downregulating TH2 cytokine expression in PBMCs from human patients with ragweed allergy

2001 • 134 citations

Immunotherapy with Fel d 1 peptides decreases IL-4 release by peripheral blood T cells of patients allergic to cats☆☆☆★★★

1998 • 129 citations

IL-4, IL-10, IL-13, and TGF-β from an Altered Peptide Ligand-Specific Th2 Cell Clone Down-Regulate Adoptive Transfer of Experimental Autoimmune Encephalomyelitis

2000 • 128 citations

Fel d 1 peptides: effect on skin tests and cytokine synthesis in cat-allergic human subjects

1996 • 128 citations

Differential IgE recognition of recombinantAspergillus fumigatus allergens by cystic fibrosis patients with allergic bronchopulmonary aspergillosis orAspergillus allergy

1998 • 127 citations

Systemic Immunological Changes Induced by Administration of Grass Pollen Allergens via the Oral Mucosa during Sublingual Immunotherapy

1999 • 124 citations

Grass pollen immunotherapy: Symptomatic improvement correlates with reductions in eosinophils and IL-5 mRNA expression in the nasal mucosa during the pollen season

2001 • 122 citations

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2001 • 118 citations

Hypersensitivity pneumonitis: a comprehensive review.

2001 • 116 citations

Infections with Aspergillus Species

1993 • 114 citations

What establishes a protein as an allergen?

2001 • 112 citations

T Cell Epitope-Containing Hypoallergenic Recombinant Fragments of the Major Birch Pollen Allergen, Bet v 1, Induce Blocking Antibodies

2000 • 111 citations

Effects of Itraconazole Therapy in Allergic Bronchopulmonary Aspergillosis

1999 • 110 citations

Effects of peptide therapy on ex vivo T-cell responses

1998 • 109 citations

Asp f I CD4 + TH2-like T-cell lines in allergic bronchopulmonary aspergillosis

1994 • 105 citations

The spectrum of pulmonary infections in cancer patients

2001 • 103 citations

DNA Vaccines − A Modern Gimmick or a Boon to Vaccinology?

1997 • 101 citations

Antifungal therapies for allergic bronchopulmonary aspergillosis in people with cystic fibrosis

2016 • 99 citations

Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets.

1997 • 97 citations

Differentiation of Regulatory T Cells 1 Is Induced by CD2 Costimulation

2001 • 97 citations

Allergic bronchopulmonary aspergillosis in corticosteroid-dependent asthmatics

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Immunotherapy of allergy: anergy, deletion, and immune deviation

1998 • 86 citations

DNA-based vaccination against murine paracoccidioidomycosis using the gp43 gene from Paracoccidioides brasiliensis

2000 • 86 citations

Allergen‐induced Th1 and Th2 cytokine secretion in relation to specific allergen sensitization and atopic symptoms in children

2001 • 83 citations

Polarized Type 1 Cytokine Profile in Bronchoalveolar Lavage T Cells of Patients with Hypersensitivity Pneumonitis

1999 • 83 citations

Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis

2000 • 82 citations

T Cell Costimulatory Blockade

1999 • 75 citations

Aspergillus fumigatus and Aspergillosis

2021 • 73 citations

Increased antigen-specific Th-2 response in allergic bronchopulmonary aspergillosis (ABPA) in patients with cystic fibrosis

1999 • 72 citations

Role of chemokines in fungal infections

2001 • 72 citations

Diagnosis and Treatment of Allergic Bronchopulmonary Aspergillosis

2001 • 70 citations

Aspergillus fumigatus spore concentration in outside air: Cardiff and St Louis compared

1984 • 70 citations

CD40‐deficient dendritic cells producing interleukin‐10, but not interleukin‐12, induce T‐cell hyporesponsiveness in vitro and prevent acute allograft rejection

1999 • 69 citations

The Role of Interleukin 10 in the Regulation of Allergic Immune Responses

2001 • 69 citations

Regulation of Specific Immune Responses by Chemical and Structural Modifications of Allergens

2000 • 68 citations

Peptide-Mediated Immune Responses in Specific Immunotherapy

2000 • 67 citations

Molecular cloning and expression of a recombinant Aspergillus fumigatus protein Asp f II with significant immunoglobulin E reactivity in allergic bronchopulmonary aspergillosis

1996 • 66 citations

Regulatory function ofin vivoanergized CD4⁺T cells

2001 • 63 citations

Serum Stimulates Growth of and Proteinase Secretion byAspergillus fumigatus

2002 • 63 citations

Diagnosis and Treatment of Allergic Bronchopulmonary Aspergillosis

2001 • 63 citations

Toll-like receptors: cellular signal transducers for exogenous molecular patterns causing immune responses

2001 • 63 citations

Purified Recombinant A. fumigatus Allergens Induce Different Responses in Mice

2001 • 62 citations

Production of cytokines by alveolar and peritoneal macrophages stimulated byAspergillus fumigatusconidia or hyphae

1996 • 62 citations

Oligodeoxynucleotides containing CpG motifs modulate the allergic TH2 response of BALB/c mice to Bet v 1, the major birch pollen allergen☆☆☆★

1999 • 62 citations

Immunotherapy with a calcium phosphate‐adsorbed five‐grass‐pollen extract in seasonal rhinoconjunctivitis: a double‐blind, placebo‐controlled study

2001 • 60 citations

Allergic bronchopulmonary aspergillosis: New concepts of pathogenesis and treatment

2001 • 57 citations

DNA-based vaccination reduces the risk of lethal anaphylactic hypersensitivity in mice

2000 • 57 citations

Conformational and Linear B-Cell Epitopes of Asp f 2, a Major Allergen ofAspergillus fumigatus, Bind Differently to Immunoglobulin E Antibody in the Sera of Allergic Bronchopulmonary Aspergillosis Patients

1999 • 56 citations

Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities.

1997 • 55 citations

An overview of macrophage-fungal interactions

1986 • 54 citations

Get into the groove! Targeting antigens to MHC class II

1999 • 52 citations

Specific IgG subclass antibody pattern to Aspergillus fumigatus in patients with cystic fibrosis with allergic bronchopulmonary aspergillosis (ABPA)

1999 • 52 citations

Polysaccharide Recognition by Surfactant Protein D: Novel Interactions of a C-Type Lectin with Nonterminal Glucosyl Residues

2001 • 51 citations

Role of IL-10 in allergen-specific immunotherapy and normal response to allergens

2001 • 50 citations

Effect of rush immunotherapy on airway inflammation and airway hyperresponsiveness after bronchoprovocation with allergen in asthma☆☆☆★

1998 • 49 citations

Skin‐test reactivity and isotype‐specific immune responses to recombinant Asp f 3, a major allergen of Aspergillus fumigatus

1998 • 49 citations

Inhibition of the transcription factors NF-kappa B and AP-1 underlies loss of cytokine gene expression in rat alveolar macrophages treated with a diffusible product from the spores of Aspergillus fumigatus.

1996 • 48 citations

Fungal infections in transplant recipients

2001 • 48 citations

Identification of vacuolar serine proteinase as a major allergen of Aspergillus fumigatus by immunoblotting and N‐terminal amino acid sequence analysis

2001 • 48 citations

TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27Kip1

2001 • 46 citations

Isoforms of the Major Allergen of Birch Pollen Induce Different Immune Responses after Genetic Immunization

1999 • 45 citations

Cloning and expression of Aspergillus fumigatus allergen Asp f 16 mediating both humoral and cell‐mediated immunity in allergic bronchopulmonary aspergillosis (ABPA)

2001 • 45 citations

Genetic Immunisation with Bovine β-Lactoglobulin cDNA Induces a Preventive and Persistent Inhibition of Specific Anti-BLG IgE Response in Mice

2001 • 44 citations

The role of antigen-presenting cells in the regulation of allergen-specific T cell responses

1998 • 44 citations

Mechanisms and consequences of peptide selection by the I‐A^k class II molecule

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CpG oligonucleotide modulation of allergic inflammation

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2001 • 41 citations

Immunodominant peptide epitopes of allergen, Asp f 1 from the fungus aspergillus fumigatus

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Non-anaphylactic combination of partially deleted fragments of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy

1999 • 40 citations

The Efficacy of Immunotherapy in an Experimental Murine Model of Allergic Asthma Is Related to the Strength and Site of T Cell Activation During Immunotherapy

2000 • 38 citations

Role of costimulatory molecules in autoimmunity.

2000 • 36 citations

Expression and functional significance of CTLA-4, a negative regulator of T cell activation.

2001 • 35 citations

Venom immunotherapy induces monocyte activation

2001 • 35 citations

Antibody Binding of Deletion Mutants of Asp f 2, the Major Aspergillus fumigatus Allergen

2000 • 33 citations

T Cell Proliferation and Cytokine Secretion to T Cell Epitopes of Asp f 2 in ABPA Patients

2001 • 32 citations

Killing ofAspergillus fumigatusspores by human lung macrophages: a paradoxical effect of heat-labile serum components

1989 • 32 citations

Modified T‐cell activation pattern during specific immunotherapy (SIT) in cat‐allergic patients

1999 • 27 citations

Mechanisms and Target Sites of Damage in Killing ofCandida albicansHyphae by Human Polymorphonuclear Neutrophils

1997 • 27 citations

Intravenous injection of major and cryptic peptide epitopes of ribotoxin, Asp f 1 inhibits T cell response induced by crude Aspergillus fumigatus antigens in mice☆

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35 Allergic Bronchopulmonary Aspergillosis in cystic fibrosis

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CD28 and T cell co-stimulation.

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Current pharmacotherapy of allergic bronchopulmonary aspergillosis

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2000 • 24 citations

Cross-Reactivity of T-Cell Clones Specific for Altered Peptide Ligands of Myelin Basic Protein

1999 • 23 citations

Allergic bronchopulmonary aspergillosis: New concepts of pathogenesis and treatment

2001 • 21 citations

Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy

2001 • 21 citations

Identification and evaluation of a major cytotoxin of A. fumigatus.

1997 • 20 citations

Clinical and immunologic changes after allergen immunotherapy with Hop Japanese pollen

2001 • 20 citations

Allergic Bronchopulmonary Aspergillosis in Patients with Cystic Fibrosis

1990 • 19 citations

Cytokine production by peripheral blood mononuclear cells following birch-pollen immunotherapy

2000 • 19 citations

Diagnosis and immunotherapy of mould allergy. VIII. Qualitative and quantitative estimation of IgE in Cladosporium immunotherapy.

1988 • 18 citations

New insight into immunological mechanisms of venom immunotherapy

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Immune response modulation by recombinant peptides expressed in virus-like particles

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Class specific antibodies in serodiagnosis of farmer's lung.

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Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis

1991 • 15 citations

Marker antigens to assess exposure to molds and their allergens.I. Aspergillus fumigatus

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Overexpression of IL-10 mRNA in gut mucosa of patients with allergic asthma

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Detection of immunoglobulins G and A to Aspergillus fumigatus by immunoblot analysis for monitoring Aspergillus-induced lung diseases

1998 • 13 citations

Differential IgE recognition of recombinant Aspergillus fumigatus allergens by cystic fibrosis patients with allergic bronchopulmonary aspergillosis or Aspergillus allergy

1998 • 10 citations

Detection of IgG and IgE antibodies to Aspergillus fumigatus in human sera by immunogold assay

1990 • 9 citations

TNF-alpha, IL-6 and IFN-gamma secreted by bronchoalveolar leukocytes isolated from patients with bronchial asthma, complicated by fungal airways infections.

1998 • 8 citations

Use of altered peptide ligands to modulate immune responses as a possible immunotherapy for allergies

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New insight into immunological mechanisms of venom immunotherapy

2001 • 6 citations

Serum IFN-gamma and IL-10 levels before and after specific immunotherapy in patients with allergic rhinitis.

1999 • 4 citations

Genetic immunisation with bovine beta-lactoglobulin cDNA induces a preventive and persistent inhibition of specific anti-BLG IgE response in mice

2001 • 2 citations

Regulatory function of in vivo anergized CD4+ T cells

2001 • 2 citations

913 Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis

2000 • 2 citations