What establishes a protein as an allergen?

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

The Th1/Th2 paradigm

1997 • 1,102 citations

Stability of food allergens to digestion in vitro

1996 • 903 citations

Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients.

1990 • 807 citations

Bovine β-lactoglobulin at 1.8 Å resolution — still an enigmatic lipocalin

1997 • 677 citations

Identification of Profilin as a Novel Pollen Allergen; IgE Autoreactivity in Sensitized Individuals

1991 • 646 citations

Profilins constitute a novel family of functional plant pan-allergens.

1992 • 634 citations

The human IgE network

1993 • 504 citations

Allergy to Apple, Carrot and Potato in Children with Birch Pollen Allergy

1983 • 434 citations

Molecular cloning and epitope analysis of the peanut allergen Ara h 3

1999 • 408 citations

X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy

1996 • 384 citations

Identification and Mutational Analysis of the Immunodominant IgE Binding Epitopes of the Major Peanut AllergenAra h 2

1997 • 377 citations

Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography

1992 • 368 citations

Identification of tropomyosin as the major shrimp allergen and characterization of its IgE-binding epitopes.

1993 • 341 citations

Food Hypersensitivity in Patients with Pollen Allergy

1982 • 331 citations

Mapping and Mutational Analysis of the IgE‐Binding Epitopes on Ara h 1, a Legume Vicilin Protein and a Major Allergen in Peanut Hypersensitivity

1997 • 311 citations

Cloning and Sequencing of Mal d 1, the Major Allergen from Apple (Malus domestica), and Its Immunological Relationship to Bet v 1, the Major Birch Pollen Allergen

1995 • 286 citations

Allergenic activity of heated and ovomucoid-depleted egg white

1997 • 284 citations

Common epitopes of birch pollen and apples—Studies by western and northern blot

1991 • 284 citations

Protein modification by thermal processing

1998 • 283 citations

A major house dust mite allergen disrupts the immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases.

1995 • 279 citations

Identification of common allergenic structures in hazel pollen and hazelnuts: A possible explanation for sensitivity to hazelnuts in patients allergic to tree pollen

1992 • 277 citations

The major allergen of peach (Prunus persica) is a lipid transfer protein

1999 • 267 citations

Proteolytic Cleavage of CD25, the α Subunit of the Human T Cell Interleukin 2 Receptor, by Der p 1, a Major Mite Allergen with Cysteine Protease Activity

1998 • 254 citations

T cell activation-inducing epitopes of the house dust mite allergen Der p I. Proliferation and lymphokine production patterns by Der p I-specific CD4+ T cell clones.

1992 • 244 citations

Molecular Characterization of Api g 1, the Major Allergen of Celery (Apium graveolens), and Its Immumological and Structural Relationships to a Group of 17‐kDa Tree Pollen Allergens

1995 • 237 citations

Augmentation of permeability in the bronchial epithelium by the house dust mite allergen Der p1.

1995 • 233 citations

The molecular basis for allergen cross-reactivity: crystal structure and IgE-epitope mapping of birch pollen profilin

1997 • 229 citations

Role of complex asparagine-linked glycans in the allergenicity of plant glycoproteins

1996 • 217 citations

Core 1,3-fucose is a key part of the epitope recognized by antibodies reacting against plant N-linked oligosaccharides and is present in a wide variety of plant extracts

1998 • 202 citations

Celery allergy associated with birch and mugwort pollinosis

1990 • 186 citations

Interaction between Protein-Derived Immunogenic Peptides and Ia

1986 • 180 citations

Identification of the acidic and basic subunit complexes of glycinin.

1981 • 175 citations

Der p I, a major allergen of the house dust mite, proteolytically cleaves the low‐affinity receptor for human IgE (CD23)

1995 • 164 citations

Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy

1997 • 164 citations

The profilin multigene family of maize: differential expression of three isoforms

1993 • 162 citations

Cross‐reactivity among birch pollen, vegetables and fruits as detected by IgE antibodies is due to at least three distinct cross‐reactive structures

1987 • 158 citations

Peanut allergens

1998 • 140 citations

Bet v 1, the major birch pollen allergen, and Mal d 1, the major apple allergen, cross-react at the level of allergen-specific T helper cells☆☆☆★★★

1998 • 137 citations

The biochemistry of common aeroallergens

1996 • 136 citations

The Specificity and Regulation of T-Cell Responsiveness to Allergens

1991 • 135 citations

IgE cross‐reactivity between birch pollen, mugwort pollen and celery is due to at least three distinct cross‐reacting allergens: immunoblot investigation of the birch‐mugwort‐celery syndrome

1996 • 135 citations

The crystal structure of a major allergen from plants

1997 • 128 citations

A major continuous allergenic epitope of bovine β‐lactoglobulin recognized by human IgE binding

1994 • 127 citations

Identification of profilin as an IgE‐binding component in latex from Hevea brasiliensis: clinical implications

1995 • 127 citations

Involvement of Carbohydrate Epitopes in the IgE Response of Celery–Allergic Patients

1999 • 122 citations

IgE-binding and histamine-release capabilities of the main carbohydrate component isolated from the major allergen of olive tree pollen, Ole e 1

1999 • 117 citations

Identification of Soybean Allergens by Immunoblotting with Sera from Soy-Allergic Adults

1990 • 117 citations

Structure of antigens

1992 • 111 citations

T-cell responses to allergens: epitope-specificity and clinical relevance

1996 • 110 citations

Solution Structure of Der f 2, the Major Mite Allergen for Atopic Diseases

1998 • 107 citations

The biosynthesis and processing of high molecular weight precursors of soybean glycinin subunits.

1982 • 91 citations

Evidence for a lipid transfer protein as the major allergen of apricot

2000 • 89 citations

Overlapping T-cell epitopes in the group I allergen of species restricted by HLA-DP and HLA-DR class II molecules

1994 • 89 citations

Cloning and sequencing of a cDNA expressing a recombinant house dust mite protein that binds human IgE and corresponds to an important low molecular weight allergen.

1989 • 88 citations

What Makes an Allergen an Allergen

1978 • 86 citations

T-cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense): Evidence for crossreacting and non-crossreacting T-cell epitopes within grass group I allergens

1995 • 84 citations

Characterization of cat dander-specific T lymphocytes from atopic patients.

1994 • 82 citations

Probing the Molecular Basis of Allergy

1999 • 82 citations

IgE reactivity to Api g 1, a major celery allergen, in a Central European population is based on primary sensitization by Bet v 1☆☆☆★

1999 • 69 citations

Immunological and structural similarities among allergens: Prerequisite for a specific and component‐based therapy of allergy

1996 • 68 citations

The amino acid sequence of the A2B1a subunit of glycinin.

1984 • 68 citations

Identification of epitopes within beta lactoglobulin recognised by polyclonal antibodies using phage display and PEPSCAN

1998 • 65 citations

Epitope analysis of the allergen ovalbumin (Gal d II) with monoclonal antibodies and patients' IgE

1992 • 65 citations

Recombinant allergen fragments as candidate preparations for allergen immunotherapy

1997 • 62 citations

A study of allergens in celery with cross‐sensitivity to mugwort and birch pollens

1988 • 61 citations

Food allergen (peanut)–specific T clones generated from the peripheral blood of a patient with peanut allergy

1996 • 59 citations

Analysis of the IgE-epitope of Der f 2, a major mite allergen, by in vitro mutagenesis

1995 • 59 citations

Serological studies on heat-induced interactions of α-lactalbumin and milk proteins

1976 • 55 citations

Purification, Characterization, and cDNA Cloning of Profilin from Phaseolus vulgaris

1995 • 54 citations

Allergenic epitopes of ovalbumin (OVA) in patients with hen’s egg allergy: inhibition of basophil histamine release by haptenic ovalbumin peptide

1996 • 53 citations

Twenty years with IgE: from the identification of IgE to regulatory factors for the IgE response.

1985 • 50 citations

The Biological Function of Allergens: Relevant for the Induction of Allergic Diseases?

1998 • 46 citations

Overview on denominated allergens

1996 • 45 citations

X-Ray Crystal Structures of Birch Pollen Profilin and Phl p 2

1997 • 45 citations

An immunogenetic analysis of T-cell reactive regions on the major allergen from the house dust mite, Der p I, with recombinant truncated fragments

1994 • 45 citations

Polyclonal and clonal analysis of human CD4+ T-lymphocyte responses to nut extracts.

1995 • 44 citations

Polymerase Chain Reaction Based cDNA Cloning of Wheat Profilin: A Potential Plant Allergen

1994 • 40 citations

Cord blood mononuclear cells and milk-specific T-cell clones are tools to evaluate the residual immunogenicity of hydrolyzed milk formulas

1998 • 21 citations