New insight into immunological mechanisms of venom immunotherapy

Role of interleukin 10 in specific immunotherapy.

1998 • 980 citations

A Controlled Trial of Immunotherapy in Insect Hypersensitivity

1978 • 705 citations

Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures.

1995 • 533 citations

Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity

2000 • 394 citations

Treatment of cat allergy with T-cell reactive peptides.

1996 • 364 citations

Immunoglobulin E–independent Major Histocompatibility Complex–restricted T Cell Peptide Epitope–induced Late Asthmatic Reactions

1999 • 336 citations

IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells.

1994 • 328 citations

Insect venom immunotherapy induces interleukin‐10 production and a Th2‐to‐Th1 shift, and changes surface marker expression in venom‐allergic subjects

1997 • 287 citations

Immunotherapy with honeybee venom and yellow jacket venom is different regarding efficacy and safety

1992 • 280 citations

B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10.

1994 • 251 citations

IL‐10‐induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy

1999 • 250 citations

IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway

2000 • 233 citations

Insect allergy: The state of the art

1979 • 200 citations

Bee venom immunotherapy induces a shift in cytokine responses from a TH‐2 to a TH‐1 dominant pattern: comparison of rush and conventional immunotherapy

1995 • 191 citations

Clinical relevance of the venom-specific immunoglobulin G antibody level during immunotherapy

1982 • 177 citations

A molecular basis for T cell suppression by IL‐10: CD28‐associated IL‐10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3‐kinase binding

2000 • 177 citations

Regulation of Murine Airway Eosinophilia and Th2 Cells by Antigen-Conjugated CpG Oligodeoxynucleotides as a Novel Antigen-Specific Immunomodulator

2000 • 166 citations

Dose dependence of Hymenoptera venom immunotherapy

1981 • 147 citations

Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4⁺ T cells precedes the development of tolerance in vivo

1996 • 137 citations

The evaluation of the common diagnostic methods of hypersensitivity for bee and yellow jacket venom by means of an in-hospital insect sting

1985 • 134 citations

Mechanisms of allergen‐specific immunotherapy

2000 • 126 citations

Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-γ production of T cells

1999 • 121 citations

TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma Is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria

2000 • 108 citations

DNA‐based immunotherapeutics for the treatment of allergic disease

2001 • 102 citations

Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils

1996 • 99 citations

Immunostimulatory DNA Prepriming: A Novel Approach for Prolonged Th1-Biased Immunity

1999 • 91 citations

Modulation by IL-10 of antigen-induced IL-5 generation, and CD4+ T lymphocyte and eosinophil infiltration into the mouse peritoneal cavity.

1996 • 90 citations

Type I skin reactivity to native and recombinant phospholipase A from honeybee venom is similar

1995 • 87 citations

Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis

2000 • 82 citations

Allergen-derived long peptide immunotherapy down-regulates specific IgE response and protects from anaphylaxis

2000 • 81 citations

IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression

2001 • 75 citations

Regulation of T-helper Type 2 Cell and Airway Eosinophilia by Transmucosal Coadministration of Antigen and Oligodeoxynucleotides Containing CpG Motifs

2000 • 73 citations

Regulation of Specific Immune Responses by Chemical and Structural Modifications of Allergens

2000 • 68 citations

Kinetics and functional implications of Th1 and Th2 cytokine production following activation of peripheral blood mononuclear cells in primary culture

1996 • 67 citations

Peptide-Mediated Immune Responses in Specific Immunotherapy

2000 • 67 citations

Inducing Tolerance by Intranasal Administration of Long Peptides in Naive and Primed CBA/J Mice

2000 • 64 citations

Provocation test with a living insect as a diagnostic tool in systemic reactions to bee and wasp venom: a prospective study with emphasis on the clinical aspects

1987 • 62 citations

DNA-based vaccination reduces the risk of lethal anaphylactic hypersensitivity in mice

2000 • 57 citations

Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities.

1997 • 55 citations

Surface membrane antigen alteration on blood basophils in patients with Hymenoptera venom allergy under immunotherapy

2000 • 48 citations

An Altered Peptide Ligand Specifically Inhibits Th2 Cytokine Synthesis by Abrogating TCR Signaling

1999 • 44 citations

A comparative study of IgG subclass antibodies in patients allergic to wasp or bee venom

1994 • 41 citations

Purification and Immunobiochemical Characterization of Folding Variants of the Recombinant Major Wasp Allergen Ves v 5 (Antigen 5)

2000 • 40 citations

Early effect of ultrarush venom immunotherapy on the IgG antibody response

2000 • 38 citations

Allergen Dose Dependent Cytokine Production Regulates Specific Ige And Igg Antibody Production

1996 • 37 citations

EARLY MODIFICATIONS OF CHEMOKINE PRODUCTION AND mRNA EXPRESSION DURING RUSH VENOM IMMUNOTHERAPY

1998 • 21 citations