Non-anaphylactic combination of partially deleted fragments of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy

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1911 • 1,317 citations

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Dust mite allergens and asthma—A worldwide problem

1989 • 692 citations

The Receptor with High Affinity for Immunoglobulin E

1986 • 540 citations

Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization.

1996 • 524 citations

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1987 • 472 citations

The house-dust mite (Dermatophagoides pteronyssinus) and the allergens it produces. Identity with the house-dust allergen

1967 • 429 citations

Activation of Mast Cells for Mediator Release through IgE Receptors

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Treatment of cat allergy with T-cell reactive peptides.

1996 • 364 citations

Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: potential use of hypoallergenic isoforms for immunotherapy.

1996 • 315 citations

Immunoprophylaxis of allergen–induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization

1996 • 293 citations

Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type.

1995 • 271 citations

Nomenclature for Factors of the HLA System, 1995

1995 • 265 citations

Recombinant allergens for diagnosis and therapy of allergic disease

2000 • 248 citations

T cell activation-inducing epitopes of the house dust mite allergen Der p I. Proliferation and lymphokine production patterns by Der p I-specific CD4+ T cell clones.

1992 • 244 citations

Allergenic identity between the common floor mite (Dermatophagoides farinae Hughes, 1961) and house dust as a causative antigen in bronchial asthma

1968 • 237 citations

T CELL RECEPTOR GENE DIVERSITY AND SELECTION

1990 • 234 citations

Genetic linkage of T-cell receptor $alpha;/$delta; complex to specific IgE responses

1994 • 219 citations

Conversion of the major birch pollen allergen, Bet v 1, into two nonanaphylactic T cell epitope-containing fragments: candidates for a novel form of specific immunotherapy.

1997 • 214 citations

Conformational stability of B cell epitopes on group I and group II Dermatophagoides spp. allergens. Effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies.

1990 • 179 citations

Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy

1997 • 164 citations

Reduction in IgE binding to allergen variants generated by site-directed mutagenesis: Contribution of disulfide bonds to the antigenic structure of the major house dust mite allergen Der p 2

1996 • 162 citations

Isolation of cDNA Coding for the Major Mite Allergen <i>Der </i><i>p</i> II by IgE Plaque Immunoassay

1990 • 151 citations

Recombinant allergens for diagnosis and therapy of allergic diseases

1995 • 131 citations

T cell epitopes of house dust mite major allergen Der p II.

1993 • 124 citations

T-cell responses to allergens: epitope-specificity and clinical relevance

1996 • 110 citations

Epitope mapping of the Dermatophagoides pteronyssinus house dust mite major allergen Der p II using overlapping synthetic peptides

1991 • 103 citations

Analysis of human T cell responses to the group II allergen of Dermatophagoides species: Localization of major antigenic sites

1993 • 94 citations

Isolation of an immunodominant IgE hapten from an epitope expression cDNA library. Dissection of the allergic effector reaction.

1994 • 84 citations

House dust mite immunotherapy results in a decrease in Der p 2‐specific IFN‐γ and IL‐4 expression by circulating T lymphocytes

1997 • 78 citations

Altered T cell ligands derived from a major house dust mite allergen enhance IFN-gamma but not IL-4 production by human CD4+ T cells.

1996 • 72 citations

IgE binding studies with large peptides expressed from Der p II cDNA constructs

1991 • 64 citations

Analysis of the IgE-epitope of Der f 2, a major mite allergen, by in vitro mutagenesis

1995 • 59 citations

Allergens of the house dust mite —Immunochemical studies of four allergenic fractions

1985 • 54 citations

An immunogenetic analysis of the T-cell recognition of the major house dust mite allergen Der p 2: identification of high- and low-responder HLA-DQ alleles and localization of T-cell epitopes.

1995 • 51 citations

Effects of Amino Acid Variations in Recombinant Der f ll on Its Human IgE and Mouse IgG Recognition

1994 • 50 citations

Determination of the N- and C-terminal sequences required to bind human IgE of the major house dust mite allergen Der f 2 and epitope mapping for monoclonal antibodies

1997 • 47 citations

Regulation of the human immune response to ragweed pollen by immunotherapy. A controlled trial comparing the effect of immunosuppressive peptic fragments of short ragweed with standard treatment

1991 • 47 citations

Determination of Three Disulfide Bonds in a Major House Dust Mite Allergen, <i>Der </i><i>f</i> ll

1993 • 42 citations

Cloning and sequencing of cDNAs corresponding to mite major allergen Der f II.

1990 • 42 citations

Cloning and expression of cDNA coding for the major house dust mite allergen Der f II in Escherichia coli.

1991 • 38 citations

Modern concepts of immunotherapy

1993 • 35 citations

Cloning and Expression of cDNA Coding for the Major House Dust Mite AllergenDer fII inEscherichia coli

1991 • 33 citations

Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: A study with allergen-specific human helper T cells

1997 • 33 citations

Peptide modulation of allergen-specific immune responses

1995 • 32 citations

Oral Immunotherapy May Induce T Cell Anergy

1995 • 23 citations

Allergens of the House Dust Mite <i>Dermatophagoides farinae</i>. II. Immunological Characterization of Four Allergenic Molecules

1989 • 19 citations

Direct Expression of Der f 2, a Major House Dust Mite Allergen, in <i>Escherichia</i> <i>coli</i>

1996 • 14 citations