Molecular and cellular mechanisms of allergic disease☆☆☆

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

Requirement for IL-13 Independently of IL-4 in Experimental Asthma

1998 • 1,869 citations

Allergy: Principles and Practice.

1991 • 1,717 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

Allergy and Allergic Diseases

2001 • 1,349 citations

Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody.

1997 • 817 citations

Mechanisms of eosinophil-associated inflammation

2000 • 773 citations

Signalling through the high-affinity IgE receptor FcεRI

1999 • 730 citations

The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects.

1997 • 719 citations

Treatment of Allergic Asthma with Monoclonal Anti-IgE Antibody

1999 • 708 citations

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF

1989 • 676 citations

The Coordinated Action of CC Chemokines in the Lung Orchestrates Allergic Inflammation and Airway Hyperresponsiveness

1998 • 546 citations

Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia

1997 • 537 citations

IgE Enhances Mouse Mast Cell FcεRI Expression In Vitro and In Vivo: Evidence for a Novel Amplification Mechanism in IgE-dependent Reactions

1997 • 448 citations

Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response.

1997 • 412 citations

Immunostimulatory DNA Sequences Inhibit IL-5, Eosinophilic Inflammation, and Airway Hyperresponsiveness in Mice

1998 • 396 citations

Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics.

1992 • 364 citations

The diverse potential effector and immunoregulatory roles of mast cells in allergic disease

2000 • 361 citations

Simultaneous Disruption of Interleukin (IL)-4 and IL-13 Defines Individual Roles in T Helper Cell Type 2–mediated Responses

1999 • 352 citations

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3

1999 • 333 citations

The eosinophil as a mediator of damage to respiratory epithelium: A model for bronchial hyperreactivity

1988 • 317 citations

Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice.

1995 • 311 citations

TREATMENT OF ALLERGIC ASTHMA WITH MONOCLONAL ANTI-IgE ANTIBODY

1999 • 290 citations

Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep.

1994 • 213 citations

Molecular mechanisms of IgE regulation

2000 • 211 citations

Down-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivo.

1999 • 209 citations

Mechanisms of Acute Eosinophil Mobilization from the Bone Marrow Stimulated by Interleukin 5: The Role of Specific Adhesion Molecules and Phosphatidylinositol 3-Kinase

1998 • 204 citations

L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo.

1994 • 199 citations

IgE in asthma and atopy: cellular and molecular connections

1999 • 191 citations

Effect of Inhaled Interleukin-5 on Airway Hyperreactivity and Eosinophilia in Asthmatics

1998 • 179 citations

The Low‐Affinity Receptor for IgE

1992 • 175 citations

Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.

1997 • 171 citations

The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice.

1994 • 164 citations

Epidemiology of allergic diseases

1997 • 163 citations

Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent.

1994 • 145 citations

In Vitro Regulation of FcRIα Expression on Human Basophils by IgE Antibody

1998 • 144 citations

Pathophysiology of the inflammatory response

1999 • 135 citations

Epidemiology of asthma: the year in review

2000 • 127 citations

In vivo enhancement of the specific antibody response via the low‐affinity receptor for IgE

1993 • 104 citations

Inhibition of Eosinophil Rolling and Recruitment in P-Selectin– and Intracellular Adhesion Molecule-1–Deficient Mice

1998 • 97 citations

CD23/IgE-mediated regulation of the specific antibody response in vivo.

1994 • 93 citations

Molecular Basis of Allergic Diseases

1998 • 89 citations

E-selectin preferentially supports neutrophil but not eosinophil rolling under conditions of flow in vitro and in vivo.

1996 • 67 citations

Comparison of human eosinophil and neutrophil ligands for P-selectin: ligands for P-selectin differ from those for E-selectin.

1995 • 54 citations

Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1–deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium

2000 • 46 citations

Restoration of the Antibody Response to IgE/Antigen Complexes in CD23-Deficient Mice by CD23+ Spleen or Bone Marrow Cells

2000 • 45 citations

Granulocyte-macrophage colony-stimulating factor regulates the functional adhesive state of very late antigen-4 expressed by eosinophils.

1997 • 43 citations

Inhibition of Eosinophilic Inflammation in Allergen-Challenged TNF Receptor p55/p75– and TNF Receptor p55–Deficient Mice

2001 • 39 citations

The expression of murine B cell CD23, in vivo, is regulated by its ligand, IgE

1998 • 30 citations

Pathophysiology of Allergic Inflammation

2009 • 26 citations

Molecular modulation of allergic responses

1998 • 12 citations

Epidemiology of allergic diseases

1998 • 8 citations

Do genetics play a role in the pathogenesis of asthma?

1998 • 7 citations

The Low Affinity IgE Fc Receptor (CD23) Participates in B Cell Activation

1992 • 6 citations