Association of phosphatidylinositol 3 kinase to protein kinase C ζ during interleukin‐2 stimulation

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Cytokine signal transduction

1994 • 1,358 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Protein kinase C - a question of specificity

1994 • 958 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1985 • 813 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

Purification and characterization of phosphoinositide 3-kinase from rat liver.

1990 • 640 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

Cloning and expression of the rat prolactin receptor, a member of the growth hormone/prolactin receptor gene family

1988 • 564 citations

PKCu is a novel, atypical member of the protein kinase C family.

1994 • 519 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1994 • 450 citations

An 81 kd protein complexed with middle T antigen and pp60c-src: A possible phosphatidylinositol kinase

1987 • 346 citations

The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

1989 • 342 citations

Structural Framework for the Protein Kinase Family

1992 • 333 citations

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.

1992 • 319 citations

A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole

1991 • 204 citations

A Tightly Associated Serine/Threonine Protein Kinase Regulates Phosphoinositide 3-Kinase Activity

1993 • 199 citations

Phosphatidylinositol kinase activity associates with viral p60src protein.

1989 • 194 citations

SH2 Domains of the p85α Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors

1992 • 186 citations

Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation.

1990 • 185 citations

A specific combination of substrates is involved in signal transduction by the kit-encoded receptor.

1991 • 155 citations

Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form

1991 • 151 citations

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor.

1992 • 143 citations

The assembly of signalling complexes by receptor tyrosine kinases

1993 • 130 citations

IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase.

1991 • 126 citations

Interleukin 2- and Polyomavirus Middle T Antigen-Induced Modification of Phosphatidylinositol 3-Kinase Activity in Activated T Lymphocytes

1991 • 98 citations

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.

1993 • 98 citations

Divergent regulation of phosphatidylinositol 3-kinase P85 alpha and P85 beta isoforms upon T cell activation

1993 • 84 citations

SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors.

1992 • 74 citations

Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns

1992 • 73 citations

Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes.

1991 • 58 citations

The ζ Isoform of Protein Kinase C Controls Interleukin-2-Mediated Proliferation in a Murine T Cell Line: Evidence for an Additional Role of Protein Kinase C ϵ and β

1995 • 37 citations

High-affinity and intermediate-affinity forms of the human interleukin 2 receptor, expressed in an interleukin 9-dependent murine T cell line, deliver proliferative signals via differences in their transduction pathways

1993 • 32 citations

Inhibition of T-Cell Antigen Receptor-Mediated Transmembrane Signaling by Protein Kinase C Activation

1988 • 32 citations

Implication of Protein Kinase C in IL-2-Mediated Proliferation and Apoptosis in a Murine T Cell Clone

1994 • 24 citations

Inhibition of T-cell antigen receptor-mediated transmembrane signaling by protein kinase C activation.

1988 • 21 citations