Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

The structure, expression, and properties of additional members of the protein kinase C family.

1988 • 706 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

1989 • 508 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin.

1990 • 434 citations

A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family

1988 • 414 citations

A simple, rapid method for the purification of poly A+ RNA.

1988 • 382 citations

A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.

1992 • 340 citations

Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies.

1992 • 300 citations

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA

1988 • 285 citations

Effect of phorbol esters on protein kinase C-zeta.

1992 • 282 citations

Unique substrate specificity and regulatory properties of PKC‐ε: a rationale for diversity

1989 • 226 citations

Expression of four protein kinase C isoforms in rat fibroblasts. Distinct subcellular distribution and regulation by calcium and phorbol esters.

1992 • 160 citations

Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific.

1991 • 142 citations

Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC

1991 • 134 citations

Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts

1988 • 122 citations

A mutant protein kinase C that can transform fibroblasts

1989 • 119 citations

Transcripts encoding protein kinase C‐α, ‐ϵ, ‐ζ, and ‐ζ are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells

1992 • 111 citations

Highly lipophilic phorbol esters as inhibitors of specific [3H]phorbol 12,13-dibutyrate binding.

1985 • 110 citations

Structure and properties of a ubiquitously expressed protein kinase C, nPKCδ

1991 • 105 citations

Differential irreversible insertion of protein kinase C into phospholipid vesicles by phorbol esters and related activators.

1992 • 101 citations

Differentiation of mouse erythroleukemia cells is blocked by late up-regulation of a c-myb transgene.

1990 • 97 citations

Purification and characterization of a calcium-unresponsive, phorbol ester/phospholipid-activated protein kinase from porcine spleen.

1990 • 85 citations

Mouse protein kinase C-.delta., the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein

1991 • 85 citations

Failure of wild-type or a mutant form of protein kinase C-α to transform fibroblasts

1991 • 68 citations

Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation.

1991 • 66 citations

Expression of four protein kinase C isoforms in rat fibroblasts. Differential alterations in ras-, src-, and fos-transformed cells.

1992 • 58 citations

The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-ζ

1992 • 54 citations

Phospholipid and Ca⁺⁺ dependency of phorbol ester receptors

1985 • 53 citations

Insulin stimulates novel protein kinase C in rat adipocytes

1992 • 24 citations