Taxonomy and function of C1 protein kinase C homology domains

Protein kinase C - a question of specificity

1994 • 958 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

1995 • 643 citations

Lipid activation of protein kinase C.

1991 • 566 citations

[9] Profile analysis

1990 • 486 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain.

1994 • 406 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

1996 • 367 citations

A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.

1995 • 342 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

Activation of Yeast Protein Kinase C by Rho1 GTPase

1996 • 286 citations

Protein kinase C contains two phorbol ester binding domains.

1991 • 234 citations

The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.

1996 • 198 citations

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

1995 • 188 citations

Protein Kinase C: Seeing two domains

1995 • 186 citations

A novel partner for the GTP‐bound forms of rho and rac

1995 • 166 citations

Non-equivalent Roles for the First and Second Zinc Fingers of Protein Kinase Cδ

1996 • 133 citations

Solution structure of a cysteine rich domain of rat protein kinase C

1994 • 131 citations

Mechanism of activation of the vav protooncogene.

1991 • 122 citations

Lambda-Interacting Protein, A Novel Protein That Specifically Interacts with the Zinc Finger Domain of the Atypical Protein Kinase C Isotype λ/ι and Stimulates Its Kinase Activity In Vitro and In Vivo

1996 • 121 citations

Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products

1994 • 120 citations

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding

1991 • 115 citations

Histone acetylation in chicken erythrocytes. Rates of acetylation and evidence that histones in both active and potentially active chromatin are rapidly modified

1988 • 75 citations

The C-terminal part of diacylglycerol kinase α lacking zinc fingers serves as a catalytic domain

1996 • 66 citations

Solution Structure of Cysteine-Rich Domain of Protein Kinase Cα1

1995 • 56 citations

Diacylglycerol kinase and phosphatidic acid phosphatase—enzymes metabolizing lipid second messengers

1993 • 47 citations

A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins.

1992 • 43 citations