Biochemical properties and biological effects of p53

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

1994 • 564 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

THE TUMOR SUPPRESSOR GENES

1993 • 509 citations

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

1994 • 482 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1994 • 371 citations

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

1994 • 347 citations

p53-mediated cell death: relationship to cell cycle control.

1993 • 339 citations

The tumore suppressor p53

1993 • 336 citations

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

1994 • 310 citations

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

1993 • 305 citations

High-Resolution Structure of the Oligomerization Domain of p53 by Multidimensional NMR

1994 • 300 citations

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes.

1994 • 300 citations

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1994 • 276 citations

p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation.

1994 • 264 citations

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

1993 • 263 citations

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

1994 • 243 citations

p53 domains: identification and characterization of two autonomous DNA-binding regions.

1993 • 239 citations

Transcriptional activation by p53 correlates with suppression of growth but not transformation

1994 • 237 citations

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

1994 • 231 citations

p53-catalyzed annealing of complementary single-stranded nucleic acids.

1993 • 225 citations

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

1993 • 206 citations

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.

1994 • 168 citations

Relationship of p53 to the control of apoptotic cell death.

1994 • 163 citations

How loops, β sheets, and α helices help us to understand p53

1994 • 140 citations

Complementation by Wild-Type p53 of Interleukin-6 Effects on M1 Cells: Induction of Cell Cycle Exit and Cooperativity with c-myc Suppression

1993 • 91 citations

Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage.

1993 • 75 citations

Wild-type p53 is required for apoptosis induced by growth factor deprivation in factor-dependent leukaemic cells

1994 • 62 citations

Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP.

1994 • 60 citations

Identification of a p53 binding site in the human retinoblastoma susceptibility gene promoter.

1994 • 46 citations

Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression.

1993 • 44 citations

The Effects of SV40 Large T Antigen and p53 on Nuclear Transport Capacity in BALB/c 3T3 Cells

1994 • 22 citations