Endocytic and Exocytic Regulation of CD4 Expression and Function

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1991 • 1,327 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1991 • 760 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1994 • 701 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

How Does HIV Cause AIDS?

1993 • 668 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane

1987 • 620 citations

How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum.

1994 • 617 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

1990 • 549 citations

Crystal structure of an HIV-binding recombinant fragment of human CD4

1990 • 545 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.

1994 • 536 citations

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

1989 • 447 citations

Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160.

1988 • 442 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

The CD4 antigen: Physiological ligand and HIV receptor

1988 • 413 citations

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

1994 • 401 citations

Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae.

1994 • 389 citations

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

1990 • 375 citations

Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletion

1988 • 372 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

Alterations in T4 (CD4) Protein and mRNA Synthesis in Cells Infected with HIV

1986 • 360 citations

Identification of the residues in human CD4 critical for the binding of HIV

1989 • 357 citations

Adsorptive endocytosis of Semliki Forest virus

1980 • 354 citations

A quantitative analysis of the endocytic pathway in baby hamster kidney cells.

1989 • 315 citations

T cells can present antigens such as HIV gp120 targeted to their own surface molecules

1988 • 294 citations

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

1986 • 290 citations

Identification of a CD4 binding site on the β2 domain of HLA-DR molecules

1992 • 272 citations

Compartmentalized structure of the plasma membrane for receptor movements as revealed by a nanometer-level motion analysis.

1994 • 268 citations

Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor

1987 • 265 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes

1992 • 251 citations

Short Related Sequences in the Cytoplasmic Domains of CD4 and CD8 Mediate Binding to the Amino-Terminal Domain of the p56^lck Tyrosine Protein Kinase

1990 • 245 citations

The Ways of Endocytosis

1989 • 237 citations

CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor.

1994 • 233 citations

Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent.

1988 • 228 citations

HIV infection does not require endocytosis of its receptor, CD4

1988 • 228 citations

CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor

1990 • 228 citations

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.

1992 • 226 citations

Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells: Mechanism for persistence in AIDS

1988 • 223 citations

The tyrosine kinase connection: how GPI-anchored proteins activate T cells

1993 • 198 citations

Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: Receptor modulation and differentiation induced by phorbol ester

1987 • 187 citations

Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4

1994 • 179 citations

Endocytosis: what goes in and how?

1992 • 177 citations

CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor

1990 • 174 citations

Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4

1988 • 173 citations

Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen.

1986 • 171 citations

Binding of phorbol esters to high‐affinity sites on murine fibroblastic cells elicits a mitogenic response

1982 • 167 citations

Human immunodeficiency virus infection of T cells and monocytes proceeds via receptor-mediated endocytosis.

1988 • 163 citations

Reversible palmitoylation of the protein-tyrosine kinase p56lck.

1993 • 159 citations

Mutational analysis of the interaction between CD4 and class II MHC: Class II antigens contact CD4 on a surface opposite the gp120-binding site

1991 • 146 citations

Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase.

1990 • 145 citations

Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting.

1993 • 144 citations

The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits

1992 • 141 citations

Modulation of CD4 by antigenic activation.

1987 • 138 citations

Transient modulation and internalization of T4 antigen induced by phorbol esters.

1986 • 137 citations

Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells.

1991 • 137 citations

Synergism Between HIV gp120 and gp120-Specific Antibody in Blocking Human T Cell Activation

1989 • 135 citations

The role of CD4 in T-cell activation: accessory molecule or co-receptor?

1989 • 134 citations

Intracellular interaction of human immunodeficiency virus type 1 (ARV-2) envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane

1990 • 131 citations

Endocytosis of glycophospholipid-anchored and transmembrane forms of CD4 by different endocytic pathways.

1992 • 129 citations

Transmission of Human Immunodeficiency Virus from Monocytes to Epithelia

1991 • 127 citations

Transferrin receptors promote the formation of clathrin lattices

1991 • 122 citations

High level expression in Chinese hamster ovary cells of soluble forms of CD4 T lymphocyte glycoprotein including glycosylation variants.

1990 • 121 citations

Covalently bound myristate in a lymphoma tyrosine protein kinase.

1984 • 120 citations

Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4

1991 • 120 citations

HIV: early virus-cell interactions.

1990 • 119 citations

Gangliosides induce selective modulation of CD4 from helper T lymphocytes.

1987 • 114 citations

The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4

1993 • 114 citations

Structural features of the cytoplasmic region of CD4 required for internalization.

1990 • 111 citations

Activators of Protein Kinase C Induce Dissociation of CD4, But Not CD8, from p56 ^lck

1989 • 111 citations

The leucocyte antigen factsbook

1995 • 110 citations

Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reticulum

1990 • 108 citations

Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.

1992 • 105 citations

The mechanism of receptor‐mediated endocytosis: More questions than answers

1992 • 103 citations

T-Cell Effector Functions: Mechanisms for Delivery of Cytotoxicity and Help

1991 • 103 citations

Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells.

1989 • 102 citations

Protein lateral mobility as a reflection of membrane microstructure

1993 • 101 citations

CD4 molecules are associated with the antigen receptor complex on activated but not resting T cells.

1988 • 95 citations

p56lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation.

1992 • 94 citations

Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4

1993 • 91 citations

The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef

1994 • 89 citations

Adaptins

1992 • 89 citations

Phosphorylation of CD4 and CD8 molecules following T cell triggering.

1987 • 87 citations

Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes

1991 • 86 citations

Myristoylation-dependent Binding of HIV-1 Nef to CD4

1994 • 86 citations

CD4: Collaborator in immune recognition and HIV infection

1990 • 86 citations

Biochemical identification of a direct physical interaction between the CD4: p56^lck and T_i(TcR)/CD3 complexes

1991 • 85 citations

Downregulation of cell surface molecules during noncytopathic infection of T cells with human immunodeficiency virus

1987 • 82 citations

The T-Cell Antigen CD5 Acts as a Receptor and Substrate for the Protein-Tyrosine Kinase p56^lck

1994 • 81 citations

T4 endocytosis and phosphorylation induced by phorbol esters but not by mitogen or HIV infection.

1988 • 81 citations

The role of L3T4 in T cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal.

1986 • 78 citations

Internalization of HIV glycoprotein gp120 is associated with down-modulation of membrane CD4 and p56lck together with impairment of T cell activation.

1992 • 77 citations

Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals.

1990 • 66 citations

HIV I Infection of Dendritic Cells

1990 • 64 citations

HIV-gp120 can block CD4-class II MHC-mediated adhesion.

1990 • 63 citations

Novel T cell antigen 4-1BB associates with the protein tyrosine kinase p56lck1.

1993 • 62 citations

Disruption of the CD4-p56lck complex is required for rapid internalization of CD4.

1992 • 62 citations

Human immunodeficiency virus type 1 glycoprotein precursor retains a CD4-p56lck complex in the endoplasmic reticulum

1992 • 61 citations

Mobility of the human T lymphocyte surface molecules CD3, CD4, and CD8: regulation by a cAMP-dependent pathway.

1988 • 57 citations

The structure of an endocytosis signal

1992 • 56 citations

Internalization efficiency of the transferrin receptor

1992 • 55 citations

Membrane interactions of pp60v-src: a model for myristylated tyrosine protein kinases.

1990 • 54 citations

Blockade of human immunodeficiency virus type 1 production in CD4+ T cells by an intracellular CD4 expressed under control of the viral long terminal repeat.

1993 • 51 citations

Sequences present in the cytoplasmic domain of CD4 are necessary and sufficient to confer sensitivity to the human immunodeficiency virus type 1 Vpu protein

1994 • 50 citations

Penetration of CD4 T cells by HIV-1. The CD4 receptor does not internalize with HIV, and CD4-related signal transduction events are not required for entry.

1991 • 50 citations

The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells.

1994 • 48 citations

Mechanism of action of the monosialoganglioside GM1 as a modulator of CD4 expression. Evidence that GM1-CD4 interaction triggers dissociation of p56lck from CD4, and CD4 internalization and degradation.

1993 • 47 citations

Biological, molecular, and structural analysis of a cytopathic variant from a molecularly cloned simian immunodeficiency virus

1994 • 44 citations

The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck.

1994 • 44 citations

p56lck protein-tyrosine kinase is cytoskeletal and does not bind to polyomavirus middle T antigen

1988 • 42 citations

Phorbol ester modulation of T-cell antigens in the Jurkat lymphoblastic leukemia cell line.

1983 • 41 citations

CD4 and CD7 molecules as targets for drug delivery from antibody bearing liposomes

1991 • 38 citations

Phorbol myristate acetate-induced down-modulation of CD4 is dependent on calmodulin and intracellular calcium.

1990 • 36 citations

CD45 phosphotyrosine phosphatase and p56^/ck protein tyrosine kinase: a functional complex crucial in T cell signal transduction

1992 • 35 citations

Regulation of CD4 and CD8 surface expression on human thymocyte subpopulations by triggering through CD2 and the CD3-T cell receptor.

1989 • 34 citations

Characteristic mode of action of gangliosides in selective modulation of CD4 on human T lymphocytes

1989 • 34 citations

Cell surface comodulation of CD4 and T cell receptor by anti-CD4 monoclonal antibody.

1989 • 32 citations

Degradation of CD4 following phorbol-induced internalization in human T lymphocytes. Evidence for distinct endocytic routing of CD4 and CD3.

1992 • 30 citations

Selective down modulation of L3T4 molecules on murine thymocytes by the tumor promoter, phorbol 12-myristate 13-acetate.

1987 • 27 citations

Requirements for modulation of the CD4 molecule in response to phorbol myristate acetate. Role of the cytoplasmic domain.

1989 • 24 citations

Entry of Animal Viruses into Cells

1993 • 24 citations

The HIV-1 Surface Protein gp120 Has No Effect on Transmembrane Signal Transduction in T Cells

1992 • 22 citations

Lateral diffusion of CD4 on the surface of a human neoplastic T‐cell line probed with a fluorescent derivative of the envelope glycoprotein (gp120) of human immunodeficiency virus type 1 (HIV‐1)

1991 • 20 citations

Autonomous roles for the cytoplasmic domains of the CD2 and CD4 T cell surface antigens.

1991 • 18 citations

Glycosylation of GD4 and Thy-1

1993 • 16 citations

Intracellular diversion of glycoprotein GP160 of human immunodeficiency virus to lysosomes as a strategy of AIDS gene therapy

1993 • 16 citations

Analysis of endoproteolytic cleavage and intracellular transport of human immunodeficiency virus type 1 envelope glycoproteins using mutant CD4 molecules bearing the transmembrane endoplasmic reticulum retention signal

1993 • 14 citations

Regulation of p56lck kinase expression and control of DNA synthesis in activated human B lymphocytes

1993 • 11 citations

A lymphocyte-specific protein tyrosine kinase, p56lck, regulates the PMA-induced internalization of CD4

1992 • 7 citations

Endocytosis of the humam immunodeficiency virus in vitro

1987 • 7 citations

Structural studies of CD4: crystal structure of domains 3 and 4 and their implication for the overall receptor structure

1993 • 5 citations

Morphological analysis of the regulation of CD4 endocytosis by p56lck

1992 • 3 citations

Deleted Work

1955 • 0 citations