Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Separation of functional subsets of human T cells by a monoclonal antibody.

1979 • 1,062 citations

Resolution of phase ambiguity in macromolecular crystallography

1985 • 1,040 citations

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Selective Tropism of Lymphadenopathy Associated Virus (LAV) for Helper-Inducer T Lymphocytes

1984 • 976 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

Prediction of Protein Structure and the Principles of Protein Conformation

1989 • 814 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

Further Characterization of the Human Inducer T Cell Subset Defined by Monoclonal Antibody

1979 • 610 citations

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

1982 • 600 citations

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein

1986 • 593 citations

The molecular replacement method

1990 • 578 citations

Crystal structure of an HIV-binding recombinant fragment of human CD4

1990 • 545 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen

1987 • 485 citations

Molecular Replacement Method

1972 • 468 citations

HIV infection is blocked in vitro by recombinant soluble CD4

1988 • 446 citations

A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

1988 • 425 citations

Soluble CD4 molecules neutralize human immunodeficiency virus type 1

1988 • 403 citations

Methods and programs for direct-space exploitation of geometric redundancies

1976 • 383 citations

Epitopes of the CD4 Antigen and HIV Infection

1986 • 379 citations

Identification of the residues in human CD4 critical for the binding of HIV

1989 • 357 citations

Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen

1987 • 348 citations

Activation of human T lymphocyte subsets: helper and suppressor/cytotoxic T cells recognize and respond to distinct histocompatibility antigens.

1981 • 338 citations

Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.

1982 • 306 citations

Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4

1988 • 294 citations

Diversity of the Immunoglobulin Gene Superfamily

1989 • 293 citations

Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry.

1986 • 293 citations

Crystal structure of chaperone protein PapD reveals an immunoglobulin fold

1989 • 292 citations

The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4

1988 • 277 citations

Evolution of proteins formed by β-sheets

1982 • 275 citations

Prediction of protein structure and principles of protein conformation

1990 • 267 citations

Molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-Å resolution

1975 • 266 citations

A structure-factor least-squares refinement procedure for macromolecular structures using constrainedandrestrained parameters

1977 • 250 citations

Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins

1990 • 238 citations

Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+.

1982 • 237 citations

Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding

1989 • 227 citations

Structure of Antibody-Antigen Complexes: Implications for Immune Recognition

1988 • 207 citations

Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.

1985 • 191 citations

Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis.

1990 • 179 citations

Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding

1988 • 175 citations

Unbiased three-dimensional refinement of heavy-atom parameters by correlation of origin-removed Patterson functions

1983 • 169 citations

Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains.

1987 • 157 citations

The MHC-Binding and gp120-Binding Functions of CD4 Are Separable

1989 • 151 citations

Binding region for human immunodeficiency virus (HIV) and epitopes for HIV-blocking monoclonal antibodies of the CD4 molecule defined by site-directed mutagenesis.

1988 • 150 citations

Structural analysis of the human immunodeficiency virus-binding domain of CD4. Epitope mapping with site-directed mutants and anti-idiotypes.

1989 • 140 citations

Analysis of the site in CD4 that binds to the HIV envelope glycoprotein.

1990 • 132 citations

A system for collection and on-line integration of X-ray diffraction data from a multiwire area detector

1987 • 129 citations

Effective activation of resting mouse T lymphocytes by cross‐linking submitogenic concentrations of the T cell antigen receptor with either Lyt‐2 or L3T4

1987 • 120 citations

A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus.

1988 • 120 citations

Structural Diversity in Domains of the Immunoglobulin Superfamily

1989 • 102 citations

Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals.

1990 • 66 citations

Escherichia coliExpression, Purification, and Biological Activity of a Truncated Soluble CD4

1990 • 58 citations

Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain.

1988 • 56 citations

Crystallization of a soluble form of the rat T-cell surface glycoprotein CD4 complexed with Fab from the W3/25 monoclonal antibody

1990 • 29 citations

The alpha-chain of murine CD8 lacks an invariant Ig-like disulfide bond but contains a unique intrachain loop instead.

1989 • 22 citations

The use of phase combination in crystallographic refinement: the choice of amplitude coefficients in combined syntheses

1984 • 20 citations

Structural in variance of T4 molecules from T cell clone Of different antigen and major histocompatibility complex specificities

1985 • 19 citations