Analysis of endoproteolytic cleavage and intracellular transport of human immunodeficiency virus type 1 envelope glycoproteins using mutant CD4 molecules bearing the transmembrane endoplasmic reticulum retention signal

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

1990 • 918 citations

Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1

1987 • 883 citations

Pathogenesis of human immunodeficiency virus infection

1993 • 835 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

Control of Protein Exit from the Endoplasmic Reticulum

1989 • 794 citations

Mammalian subtilisins: The long-sought dibasic processing endoproteases

1991 • 756 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4

1992 • 553 citations

AIDS Retrovirus Induced Cytopathology: Giant Cell Formation and Involvement of CD4 antigen

1986 • 516 citations

Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum

1989 • 499 citations

Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160.

1988 • 442 citations

Retrieval of transmembrane proteins to the endoplasmic reticulum.

1993 • 414 citations

Oligomeric structure of the human immunodeficiency virus type 1 envelope glycoprotein.

1990 • 360 citations

Alterations in T4 (CD4) Protein and mRNA Synthesis in Cells Infected with HIV

1986 • 360 citations

Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41.

1990 • 348 citations

Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein

1991 • 333 citations

Mechanism of action of regulatory proteins encoded by complex retroviruses

1992 • 299 citations

HIV infection does not require endocytosis of its receptor, CD4

1988 • 228 citations

Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells: Mechanism for persistence in AIDS

1988 • 223 citations

Compartmentation of asparagine-linked oligosaccharide processing in the Golgi apparatus.

1983 • 203 citations

Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4

1988 • 173 citations

The CD4-gpl20 Interaction and Aids Pathogenesis

1991 • 137 citations

Intracellular interaction of human immunodeficiency virus type 1 (ARV-2) envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane

1990 • 131 citations

Signals for retention of transmembrane proteins in the endoplasmic reticulum studied with CD4 truncation mutants.

1991 • 122 citations

Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4

1991 • 120 citations

Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity

1992 • 120 citations

The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4

1993 • 114 citations

Structural features of the cytoplasmic region of CD4 required for internalization.

1990 • 111 citations

Inhibition of gp160 and CD4 maturation in U937 cells after both defective and productive infections by human immunodeficiency virus type 1

1991 • 74 citations

Characterization of an HIV-1 point mutant blocked in envelope glycoprotein cleavage

1990 • 71 citations

HIV interactions with CD4: a continuum of conformations and consequences

1992 • 58 citations

Role of CD4 in Normal Immunity and HIV Infection

1989 • 52 citations

HIV-1 Replication and Potential Targets for Intervention

1992 • 30 citations

Signal processing, glycosylation, and secretion of mutant hemagglutinins of a human influenza virus by Saccharomyces cerevisiae.

1987 • 28 citations

Cell surface transport, oligomerization, and endocytosis of chimeric type II glycoproteins: role of cytoplasmic and anchor domains.

1991 • 28 citations