Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Prediction of protein conformation

1974 • 3,327 citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 1,585 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

1986 • 627 citations

Protein secondary structure prediction with a neural network.

1989 • 506 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.

1987 • 355 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

The influence of basic residues on the substrate specificity of protein kinase C.

1987 • 287 citations

Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis

1989 • 272 citations

Fc receptor isoforms exhibit distinct abilities for coated pit localization as a result of cytoplasmic domain heterogeneity

1989 • 259 citations

Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies

1988 • 248 citations

A single amino acid change in the cytoplasmic domain allows the influenza virus hemagglutinin to be endocytosed through coated pits

1988 • 245 citations

Short Related Sequences in the Cytoplasmic Domains of CD4 and CD8 Mediate Binding to the Amino-Terminal Domain of the p56^lck Tyrosine Protein Kinase

1990 • 245 citations

Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent.

1988 • 228 citations

HIV infection does not require endocytosis of its receptor, CD4

1988 • 228 citations

EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.

1988 • 226 citations

Deletion of the cytoplasmic domain of the polymeric immunoglobulin receptor prevents basolateral localization and endocytosis

1986 • 202 citations

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

1985 • 199 citations

Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4

1988 • 173 citations

Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen.

1986 • 171 citations

Modulation of CD4 by antigenic activation.

1987 • 138 citations

Epidermal growth factor receptor is down-regulated by a 10,400 MW protein encoded by the E3 region of adenovirus

1989 • 138 citations

Transient modulation and internalization of T4 antigen induced by phorbol esters.

1986 • 137 citations

Signals for retention of transmembrane proteins in the endoplasmic reticulum studied with CD4 truncation mutants.

1991 • 122 citations

Structural features of the cytoplasmic region of CD4 required for internalization.

1990 • 111 citations

Phosphorylation of CD4 and CD8 molecules following T cell triggering.

1987 • 87 citations

T4 endocytosis and phosphorylation induced by phorbol esters but not by mitogen or HIV infection.

1988 • 81 citations

Functional analysis of a cytoplasmic domain-deleted mutant of the CD4 molecule.

1988 • 64 citations

High‐yield trapping of EGF‐induced receptor dimers by chemical cross‐linking ¹

1989 • 55 citations

Inhibition of antibodies to CD3 surface antigen and phytohemagglutinin-mediated T cellular responses by inhibiting Ca2+/phospholipid-dependent protein kinase activity with the aid of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride.

1987 • 38 citations

Regulation of CD4 and CD8 surface expression on human thymocyte subpopulations by triggering through CD2 and the CD3-T cell receptor.

1989 • 34 citations

Selective down modulation of L3T4 molecules on murine thymocytes by the tumor promoter, phorbol 12-myristate 13-acetate.

1987 • 27 citations

Requirements for modulation of the CD4 molecule in response to phorbol myristate acetate. Role of the cytoplasmic domain.

1989 • 24 citations

Phosphorylation and down-regulation of CD4 and CD8 in human CTLs and mouse L cells

1989 • 18 citations

Structural nature of the interaction between T lymphocyte surface molecule CD4 and the intracellular protein tyrosine kinase Ick

1990 • 17 citations