Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells.

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

1987 • 827 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Receptor-mediated endocytosis: insights from the lipoprotein receptor system.

1979 • 701 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

Membrane flow during pinocytosis. A stereologic analysis.

1976 • 639 citations

pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane

1987 • 620 citations

Molecular Biology and Function of CD4 and CD8

1989 • 388 citations

Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletion

1988 • 372 citations

Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line.

1982 • 357 citations

Adsorptive endocytosis of Semliki Forest virus

1980 • 354 citations

Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen

1987 • 348 citations

Perturbation of the T4 molecule transmits a negative signal to T cells.

1985 • 335 citations

Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism.

1988 • 299 citations

Variable and conserved neutralization antigens of human immunodeficiency virus

1986 • 296 citations

T cells can present antigens such as HIV gp120 targeted to their own surface molecules

1988 • 294 citations

Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry.

1986 • 293 citations

Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor

1987 • 265 citations

Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies.

1982 • 240 citations

HIV infection does not require endocytosis of its receptor, CD4

1988 • 228 citations

Lymphocyte activation by HIV-1 envelope glycoprotein

1988 • 224 citations

Expression and function of CD4 in a murine T-cell hybridoma

1987 • 208 citations

Preparation of F(ab′)2 fragments from mouse IgG of various subclasses

1983 • 208 citations

Transferrin receptor and its recycling in HeLa cells.

1982 • 206 citations

Lymphokine activation of T4+ T lymphocytes and monocytes.

1987 • 195 citations

Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: Receptor modulation and differentiation induced by phorbol ester

1987 • 187 citations

Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4

1988 • 173 citations

Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen.

1986 • 171 citations

Role of the L3T4-antigen in T cell activation. II. Inhibition of T cell activation by monoclonal anti-L3T4 antibodies in the absence of accessory cells.

1985 • 167 citations

Human immunodeficiency virus infection of T cells and monocytes proceeds via receptor-mediated endocytosis.

1988 • 163 citations

Transport of macrophage Fc receptors and Fc receptor-bound ligands to lysosomes.

1986 • 149 citations

Modulation of CD4 by antigenic activation.

1987 • 138 citations

Transient modulation and internalization of T4 antigen induced by phorbol esters.

1986 • 137 citations

The role of the L3T4 molecule in mitogen and antigen-activated signal transduction

1987 • 121 citations

Antibody to mannose 6-phosphate specific receptor induces receptor deficiency in human fibroblasts.

1984 • 104 citations

CD4 molecules are associated with the antigen receptor complex on activated but not resting T cells.

1988 • 95 citations

Phosphorylation of CD4 and CD8 molecules following T cell triggering.

1987 • 87 citations

T4 endocytosis and phosphorylation induced by phorbol esters but not by mitogen or HIV infection.

1988 • 81 citations

The role of L3T4 in T cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal.

1986 • 78 citations

Stimulation and proliferation of CD4⁺ peripheral blood T lymphocytes induced by an anti‐CD4 monoclonal antibody

1988 • 68 citations

Distribution of the transferrin receptor in normal human fibroblasts and fibrosarcoma cells

1983 • 48 citations

Evidence that pinocytosis in lymphoid cells has a low capacity.

1986 • 44 citations

Recognition of HIV glycoprotein gp120 by T cells. Role of monocyte CD4 in the presentation of gp120.

1989 • 24 citations

Requirements for modulation of the CD4 molecule in response to phorbol myristate acetate. Role of the cytoplasmic domain.

1989 • 24 citations