Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells.

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture

1977 • 2,134 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 1,585 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia

1965 • 1,213 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

On the entry of semliki forest virus into BHK-21 cells

1980 • 808 citations

Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes.

1988 • 785 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

1977 • 688 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

Membrane flow during pinocytosis. A stereologic analysis.

1976 • 639 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

Virus Entry into Animal Cells

1989 • 625 citations

pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane

1987 • 620 citations

Stereological estimation of the volume‐weighted mean volume of arbitrary particles observed on random sections*

1985 • 486 citations

The CD4 antigen: Physiological ligand and HIV receptor

1988 • 413 citations

A method using 3-O-methyl-D-glucose and phloretin for the determination of intracellular water space of cells in monolayer culture

1975 • 407 citations

Molecular Biology and Function of CD4 and CD8

1989 • 388 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

Adsorptive endocytosis of Semliki Forest virus

1980 • 354 citations

Perturbation of the T4 molecule transmits a negative signal to T cells.

1985 • 335 citations

A quantitative analysis of the endocytic pathway in baby hamster kidney cells.

1989 • 315 citations

Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization.

1990 • 312 citations

Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism.

1988 • 299 citations

Phorbol esters and horseradish peroxidase stimulate pinocytosis and redirect the flow of pinocytosed fluid in macrophages.

1985 • 288 citations

The Structure of the CD4 and CD8 Genes

1987 • 276 citations

Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor

1987 • 265 citations

Induction of HTLV-III/LAV from a Nonvirus-Producing T-Cell Line: Implications for Latency

1986 • 264 citations

Fc receptor isoforms exhibit distinct abilities for coated pit localization as a result of cytoplasmic domain heterogeneity

1989 • 259 citations

Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines.

1984 • 244 citations

HIV infection does not require endocytosis of its receptor, CD4

1988 • 228 citations

Meeting of the apical and basolateral endocytic pathways of the Madin-Darby canine kidney cell in late endosomes.

1989 • 226 citations

Lymphocyte activation by HIV-1 envelope glycoprotein

1988 • 224 citations

Exocytosis of pinocytosed fluid in cultured cells: kinetic evidence for rapid turnover and compartmentation.

1981 • 215 citations

The dynamic nature of the Golgi complex.

1989 • 210 citations

Rapid analytical and preparative isolation of functional endosomes by free flow electrophoresis

1987 • 208 citations

Coated pits act as molecular filters.

1980 • 208 citations

Transferrin receptor and its recycling in HeLa cells.

1982 • 206 citations

Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation.

1987 • 185 citations

Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4

1988 • 173 citations

Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen.

1986 • 171 citations

Role of the L3T4-antigen in T cell activation. II. Inhibition of T cell activation by monoclonal anti-L3T4 antibodies in the absence of accessory cells.

1985 • 167 citations

Signal transduction through cd4 receptors: stimulatory vs. inhibitory activity is regulated by cd4 proximity to the cd31t cell receptor

1988 • 166 citations

Human immunodeficiency virus infection of T cells and monocytes proceeds via receptor-mediated endocytosis.

1988 • 163 citations

Characterization of the cation-independent mannose 6-phosphate receptor-enriched prelysosomal compartment in NRK cells

1990 • 161 citations

Transient modulation and internalization of T4 antigen induced by phorbol esters.

1986 • 137 citations

Synergism Between HIV gp120 and gp120-Specific Antibody in Blocking Human T Cell Activation

1989 • 135 citations

Internalization and cycling of the T cell antigen receptor. Role of protein kinase C.

1987 • 133 citations

Human T lymphocytes and monocytes bear the same Leu-3(T4) antigen.

1986 • 121 citations

Cross‐linking of the T cell receptor complex with the subset‐specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T cells

1987 • 117 citations

Activators of Protein Kinase C Induce Dissociation of CD4, But Not CD8, from p56 ^lck

1989 • 111 citations

Comodulation of CD3 and CD4. Evidence for a specific association between CD4 and approximately 5% of the CD3:T cell receptor complexes on helper T lymphocytes.

1988 • 89 citations

CD4: Collaborator in immune recognition and HIV infection

1990 • 86 citations

T4 endocytosis and phosphorylation induced by phorbol esters but not by mitogen or HIV infection.

1988 • 81 citations

Surface redistribution of 125I-insulin in cultured human lymphocytes.

1981 • 79 citations

The role of L3T4 in T cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal.

1986 • 78 citations

Five epitopes of a differentiation antigen on human inducer T cells distinguished by monoclonal antibodies

1983 • 69 citations

HIV-gp120 can block CD4-class II MHC-mediated adhesion.

1990 • 63 citations

Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain.

1988 • 56 citations

Endocytosis and recycling of CD4

1990 • 16 citations