The molecular pathogenesis of the philadelphia-positive leukemias: Implications for diagnosis and therapy

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Bone marrow transplant

1989 • 3,423 citations

Oncogenes and signal transduction

1991 • 2,816 citations

A minute chromosome in human chronic granulocytic leukemia

1960 • 2,329 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction.

1990 • 1,484 citations

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

1982 • 1,385 citations

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

The Polymerase Chain Reaction

1990 • 1,198 citations

Prognostic discrimination in "good-risk" chronic granulocytic leukemia

1984 • 989 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

Prognostic discrimination in "good-risk" chronic granulocytic leukemia

1984 • 919 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage

1977 • 888 citations

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

1988 • 867 citations

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

1983 • 848 citations

The Chronic Myelogenous Leukemia-Specific P210 Protein Is the Product of the bcr / abl Hybrid Gene

1986 • 820 citations

Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.

1988 • 741 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.

1991 • 708 citations

Acute leukaemia in bcr/abl transgenic mice

1990 • 701 citations

Hematologic Remission and Cytogenetic Improvement Induced by Recombinant Human Interferon Alpha_Ain Chronic Myelogenous Leukemia

1986 • 675 citations

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

1989 • 607 citations

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

1988 • 602 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

1988 • 593 citations

Diagnosis and classification of the polycythemias.

1975 • 571 citations

Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.

1989 • 559 citations

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

1990 • 535 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130^gag-fps

1986 • 478 citations

Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia

1987 • 461 citations

A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia

1987 • 448 citations

[30] Use and specificity of genistein as inhibitor of protein-tyrosine kinases

1991 • 421 citations

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

1987 • 405 citations

Interferon-Alpha Produces Sustained Cytogenetic Responses in Chronic Myelogenous Leukemia

1991 • 398 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

Use of Restriction Fragment Length Polymorphisms to Determine the Clonal Origin of Human Tumors

1985 • 387 citations

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.

1987 • 380 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1990 • 371 citations

Selective Inhibition of Leukemia Cell Proliferation by BCR-ABL Antisense Oligodeoxynucleotides

1991 • 353 citations

Unique Forms of the abl Tyrosine Kinase Distinguish Ph ¹ -Positive CML from Ph ¹ -Positive ALL

1987 • 344 citations

Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia

1983 • 337 citations

Long-Term Marrow Culture Reveals Chromosomally Normal Hematopoietic Progenitor Cells in Patients with Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia

1983 • 335 citations

Chronic Myelocytic Leukemia

1978 • 332 citations

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps.

1986 • 317 citations

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.

1989 • 300 citations

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

1992 • 295 citations

The Distribution of the Philadelphia Chromosome in Patients with Chronic Myelogenous Leukemia

1963 • 294 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

Tyrphostins Inhibit Epidermal Growth Factor (EGF)-Receptor Tyrosine Kinase Activity in Living Cells and EGF-Stimulated Cell Proliferation

1989 • 286 citations

Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.

1991 • 286 citations

A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia

1987 • 278 citations

The BCR gene encodes a novel serine/threonine kinase activity within a single exon

1991 • 273 citations

Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

1985 • 266 citations

Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction.

1991 • 266 citations

Detection of residual leukemia after bone marrow transplant for chronic myeloid leukemia: role of polymerase chain reaction in predicting relapse

1991 • 265 citations

Tyrphostins. II. Heterocyclic and .alpha.-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases

1991 • 260 citations

Evidence of a New Chimericbcr/c-ablmRNA in Patients with Chronic Myelocytic Leukemia and the Philadelphia Chromosome

1985 • 253 citations

Expression of a Distinctive BCR-ABL Oncogene in Ph ¹ -Positive Acute Lymphocytic Leukemia (ALL)

1988 • 252 citations

Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.

1988 • 250 citations

A novel putative tyrosine kinase receptor with oncogenic potential.

1991 • 249 citations

Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562.

1983 • 244 citations

The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.

1991 • 237 citations

RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes.

1987 • 231 citations

p53 in chronic myelogenous leukemia in acute phase.

1991 • 224 citations

The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.

1991 • 224 citations

Staging and prognosis in chronic myelogenous leukemia.

1988 • 221 citations

Chronic myelogenous leukemia: a multivariate analysis of the associations of patient characteristics and therapy with survival

1985 • 214 citations

An 8-kilobase abl RNA transcript in chronic myelogenous leukemia.

1984 • 210 citations

Myeloproliferative disorders (MPD): myelofibrosis, myelosclerosis, extramedullary hematopoiesis, undifferentiated MPD, and hemorrhagic thrombocythemia.

1975 • 209 citations

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

1989 • 207 citations

A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia

1987 • 201 citations

Ph1-Positive Leukaemia, Including Chronic Myelogenous Leukaemia

1980 • 191 citations

Interferon alpha-2b as therapy for Ph'-positive chronic myelogenous leukemia: a study of 82 patients treated with intermittent or daily administration

1988 • 184 citations

Detection of Philadelphia chromosome-positive cells by the polymerase chain reaction following bone marrow transplant for chronic myelogenous leukemia

1989 • 183 citations

The CML-Specific P210bcr/ablProtein, Unlike v-abl, Does Not Transform NIH/3T3 Fibroblasts

1987 • 181 citations

The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc.

1989 • 180 citations

Philadelphia-Chromosome-Positive and -Negative Chronic Myelocytic Leukemia

1970 • 179 citations

bcr-abl oncogene renders myeloid cell line factor independent: potential autocrine mechanism in chronic myeloid leukemia.

1988 • 177 citations

Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A

1988 • 166 citations

Cytogenetics of chronic myelogenous leukemia.

1988 • 164 citations

Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia.

1986 • 160 citations

Is the chromosomal region 9q34 always involved in variants of the Ph1 translocation?

1984 • 158 citations

Transforming genes in chronic myelogenous leukemia.

1988 • 155 citations

Current topics in microbiology and immunology

1971 • 154 citations

Association of amplified oncogene c-myc with an abnormally banded chromosome 8 in a human leukaemia cell line

1983 • 152 citations

POLYMERASE CHAIN REACTION FOR DETECTION OF RESIDUAL LEUKAEMIA

1989 • 152 citations

Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase.

1985 • 150 citations

Successful autografting in chronic myeloid leukaemia after maintenance of marrow in culture.

1989 • 149 citations

Six-year follow-up of the clinical significance of karyotype in acute lymphoblastic leukemia

1989 • 149 citations

Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.

1991 • 149 citations

Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells.

1989 • 145 citations

C-abl and bcr are rearranged in a Ph1-negative CML patient.

1985 • 144 citations

Philadelphia-negative (Ph-) chronic myeloid leukemia (CML): comparison with Ph+ CML and chronic myelomonocytic leukemia. The Groupe Francais de Cytogenetique Hematologique

1991 • 139 citations

Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia

1990 • 138 citations

Molecular relapse in chronic myelogenous leukemia patients after bone marrow transplantation detected by polymerase chain reaction.

1990 • 137 citations

Hormonal regulation of the rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation

1984 • 132 citations

A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity.

1980 • 132 citations

Successful engraftment of blood derived normal hemopoietic stem cells in chronic myelogenous leukemia.

1981 • 131 citations

A bcr-v-abl oncogene induces lymphomas in transgenic mice.

1989 • 125 citations

Blast crisis in a murine model of chronic myelogenous leukemia.

1991 • 119 citations

Induction of erythroid differentiation of K562 human leukemic cells by herbimycin A, an inhibitor of tyrosine kinase activity.

1989 • 119 citations

Prognostic discrimination among younger patients with chronic granulocytic leukemia: relevance to bone marrow transplantation

1985 • 118 citations

Interferon-alpha overrides the deficient adhesion of chronic myeloid leukemia primitive progenitor cells to bone marrow stromal cells

1991 • 117 citations

Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells

1991 • 117 citations

Detection of two alternative bcr/abl mRNA junctions and minimal residual disease in Philadelphia chromosome positive chronic myelogenous leukemia by polymerase chain reaction

1989 • 117 citations

Staging of Chronic Myeloid Leukaemia

1981 • 115 citations

Philadelphia chromosome‐negative chronic myelogenous leukaemia: a morphological reassessment

1985 • 109 citations

Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia

1990 • 108 citations

Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants

1989 • 107 citations

Chromosomal translocations activating myc sequences and transduction of v-abl are critical events in the rapid induction of plasmacytomas by pristane and abelson virus.

1984 • 106 citations

DETECTION OF RESIDUAL bcr/abl TRANSLOCATION BY POLYMERASE CHAIN REACTION IN CHRONIC MYELOID LEUKAEMIA PATIENTS AFTER BONE-MARROW TRANSPLANTATION

1989 • 106 citations

A specific inhibitor for tyrosine protein kinase from Pseudomonas.

1986 • 105 citations

Human factor VIII:C purified using monoclonal antibody to von Willebrand factor.

1988 • 105 citations

Rearrangement of the bcr Gene in Philadelphia-Chromosome-Negative Chronic Myeloid Leukemia

1987 • 103 citations

Novel chimaeric protein expressed in Philadelphia positive acute lymphoblastic leukaemia

1987 • 102 citations

Abelson murine leukemia virus mutants deficient in kinase activity and lymphoid cell transformation

1980 • 101 citations

CML patients in blast crisis have breakpoints localized to a specific region of the BCR

1987 • 100 citations

Detection of minimal residual disease in chronic myeloid leukemia patients after bone marrow transplantation by polymerase chain reaction.

1990 • 99 citations

bcr-abl RNA in patients with chronic myelogenous leukemia

1987 • 99 citations

The site of the breakpoint within the bcr is a prognostic factor in Philadelphia-positive CML patients [see comments]

1988 • 96 citations

The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.

1989 • 96 citations

Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors.

1990 • 96 citations

Inhibitory Effects of Human Leukocyte and Fibroblast Interferons on Normal and Chronic Myelogenous Leukemic Granulocytic Progenitor Cells

1981 • 93 citations

Analysis of breakpoints within the bcr gene and their correlation with the clinical course of Philadelphia-positive chronic myelogenous leukemia

1988 • 92 citations

GENOMIC ALTERATIONS INVOLVING THE C-MYC PROTO-ONCOGENE LOCUS DURING THE EVOLUTION OF A CASE OF CHRONIC GRANULOCYTIC LEUKAEMIA

1984 • 91 citations

The use of the polymerase chain reaction for the detection of minimal residual malignant disease [editorial]

1991 • 91 citations

Therapy of chronic myelogenous leukemia with recombinant interferon- gamma

1987 • 91 citations

Differences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogene.

1991 • 89 citations

Expression of c-abl in Philadelphia-positive acute myelogenous leukemia

1987 • 89 citations

Philadelphia chromosome-negative chronic myelogenous leukemia without breakpoint cluster region rearrangement: a chronic myeloid leukemia with a distinct clinical course

1990 • 88 citations

Rearrangement of the bcr gene in Philadelphia chromosome-negative chronic myeloid leukemia

1986 • 85 citations

An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene.

1990 • 84 citations

Rearrangement in the Breakpoint Cluster Region and the Clinical Course in Philadelphia-Negative Chronic Myelogenous Leukemia

1986 • 77 citations

Analysis of breakpoints within the bcr gene and their correlation with the clinical course of Philadelphia-positive chronic myelogenous leukemia

1988 • 77 citations

[29] Inhibition of protein-tyrosine kinases by tyrphostins

1991 • 76 citations

The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers.

1991 • 75 citations

Ph1-Negative Chronic Granulocytic Leukemia: A Nonentity

1986 • 74 citations

The Cytogenetics of Chronic Granulocytic Leukaemia

1977 • 74 citations

Chronic Granulocytic Leukaemia with Ph¹ Negative Cells in Bone Marrow and a Ten Year Remission after Busulphan Hypoplasia

1972 • 73 citations

Phenotypic and molecular heterogeneity in Philadelphia chromosome- positive acute leukemia

1988 • 73 citations

Localization of tyrosine kinase-coding region in v-abl oncogene by the expression of v-abl-encoded proteins in bacteria.

1985 • 70 citations

The minimum transforming region of v-abl is the segment encoding protein-tyrosine kinase

1985 • 70 citations

Growth inhibitory effects of interferon on normal and malignant human haemopoietic cells

1977 • 69 citations

Late-appearing Philadelphia chromosome in two patients with chronic myelogenous leukemia

1980 • 69 citations

In Vivo Sensitivity and Resistance of Chronic Myelogenous Leukemia Cells to a-Interferon: Correlation with Receptor Binding and Induction of 2, 5-Oligoadenylate Synthetase

1986 • 68 citations

Philadelphia-positive acute leukemia: lineage promiscuity and inconsistently rearranged breakpoint cluster region.

1988 • 68 citations

Alteration in bone marrow adherent layer growth factor expression: a novel mechanism of chronic myelogenous leukemia progression

1991 • 67 citations

Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript [see comments]

1990 • 65 citations

Chromosome Pattern of Bone Marrow Fibroblasts in Patients with Chronic Granulocytic Leukaemia

1969 • 64 citations

Minimal residual disease in patients with chronic myelogenous leukemia undergoing long-term treatment with recombinant interferon alpha-2b alone or in combination with interferon gamma

1991 • 63 citations

Discordant maturation as the primary biological defect in chronic myelogenous leukemia.

1988 • 63 citations

Cytogenetic evolution and clonal proliferation in acute transformation of chronic granulocytic leukaemia

1968 • 60 citations

Evidence for a multipotential stem cell disease in some childhood Philadelphia chromosome-positive acute lymphoblastic leukemia

1987 • 59 citations

The genetics of childhood cancer

1975 • 59 citations

The location of breakpoints within the breakpoint cluster region (bcr) of chromosome 22 in chronic myeloid leukemia.

1988 • 58 citations

Sulfonylbenzoyl-nitrostyrenes: Potential bisubstrate type inhibitors of the EGF-receptor tyrosine protein kinase

1991 • 58 citations

Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine.

1987 • 57 citations

Nucleotide sequence analysis of human abl and bcr-abl cDNAs.

1989 • 56 citations

Chronic myeloid leukemia with permanent disappearance of the Ph1 chromosome and development of new clonal subpopulations

1979 • 54 citations

Molecular analysis of Philadelphia positive essential thrombocythemia.

1989 • 53 citations

Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line.

1992 • 51 citations

The application of X‐chromosome gene probes to the diagnosis of myeloproliferative disease

1989 • 51 citations

Molecular Pathogenesis of Ph-Positive Leukemias

1989 • 48 citations

Bone marrow transplantation for chronic myeloid leukemia.

1984 • 48 citations

Clonal lymphoid progenitor cell lines expressing the BCR/ABL oncogene retain full differentiative function.

1990 • 44 citations

Chronic myelogenous leukemia: amplification of a rearranged c-abl oncogene in both chronic phase and blast crisis

1987 • 44 citations

Mechanism of action of α interferon in chronic granulocytic leukaemia: evidence for preferential inhibition of late progenitors

1989 • 44 citations

Molecular abnormalities of bcr and c-abl in chronic myelogenous leukemia associated with a long chronic phase

1988 • 42 citations

[32] Use of erbstatin as protein-tyrosine kinase inhibitor

1991 • 41 citations

The role of alternative splicing patterns of BCR/ABL transcripts in the generation of the blast crisis of chronic myeloid leukaemia

1990 • 40 citations

Detection of breakpoint cluster region- negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow

1990 • 40 citations

Expression of bcr-abl fusion transcripts following bone marrow transplantation for Philadelphia chromosome-positive leukemia.

1990 • 38 citations

T cell lineage involvement in lymphoid blast crisis of chronic myeloid leukemia

1985 • 38 citations

Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis.

1987 • 38 citations

Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c-abl sequences in blast crisis.

1986 • 37 citations

Mutation of a phenylalanine conserved in SH3-containing tyrosine kinases activates the transforming ability of c-Abl.

1993 • 37 citations

Myeloproliferative disorders: usefulness of X-linked probes in diagnosis.

1989 • 36 citations

Intensive combination chemotherapy and autologous bone marrow transplantation leads to the reappearance of philadelphia chromosome-negative cells in chronic myelogenous leukemia

1991 • 34 citations

The effects of interferon‐α on the proliferation of CML progenitor cells in vitro are not related to the precise position of the M‐BCR breakpoint

1991 • 31 citations

Molecular analysis of clonality and bcr rearrangements in Philadelphia chromosome-positive acute lymphoblastic leukemia

1988 • 31 citations

Comparative biochemical and cytogenetic studies of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and other 22q 11 variants

1989 • 30 citations

Activation of murine c-abl protooncogene: effect of a point mutation on oncogenic activation.

1990 • 30 citations

Assessment of c-myc expression in individual leukemic cells

1988 • 29 citations

PERSISTENCE OF bcr-abl GENE EXPRESSION FOLLOWING BONE MARROW TRANSPLANTATION FOR CHRONIC MYELOGENOUS LEUKEMIA IN CHRONIC PHASE

1991 • 29 citations

Heterogeneity in expression of the bcr-abl fusion transcript in CML blast crisis.

1987 • 28 citations

Update on therapeutic options for chronic myelogenous leukemia.

1990 • 26 citations

Interferon in the treatment of myeloproliferative diseases.

1990 • 26 citations

Alpha interferon therapy for haematological malignancies: correlation between in vivo induction of the 2′,5′ oligoadenylate system and clinical response

1990 • 25 citations

Detection of breakpoint cluster region- negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow

1990 • 25 citations

Complete remission after autografting for chronic myeloid leukaemia

1987 • 24 citations

Deficiency of a phosphatidylinositol-anchored cell adhesion molecule influences haemopoietic progenitor binding to marrow stroma in chronic myeloid leukaemia.

1991 • 23 citations

Interferon-alpha alters the distribution of CFU-GM between the adherent and nonadherent compartments in long-term cultures of chronic myeloid leukemia marrow.

1991 • 22 citations

Molecular heterogeneity of adult Philadelphia chromosome-positive acute lymphoblastic leukemia.

1988 • 22 citations

Fusion of the bcr and the c-abl genes in Ph'-positive acute lymphocytic leukemia with no rearrangement in the breakpoint cluster region.

1988 • 21 citations

Factors influencing survival in philadelphia chromosome positive chronic myelocytic leukemia

1982 • 21 citations

Clinical value of PCR in diagnosis and follow-up of leukaemia and lymphoma: report of the third Workshop of the Molecular Biology/BMT study group.

1991 • 19 citations

Bone marrow progenitor cells induce a regulatory autologous proliferative T lymphocyte response.

1989 • 18 citations

Chromosome 9 in variant Ph translocations

1985 • 17 citations

Analysis of interferon-inducible genes in cells of chronic myeloid leukemia patients responsive or resistant to an interferon-alpha treatment

1990 • 17 citations

Does the site of the breakpoint on chromosome 22 influence the duration of the chronic phase in chronic myeloid leukemia?

1989 • 16 citations

Lack of breakpoint cluster region rearrangement in marrow fibroblasts of patients with Philadelphia chromosome-positive chronic myelogenous leukemia.

1988 • 15 citations

Interferon alpha in the therapy of CML

1991 • 15 citations

Chronic Myelogenous Leukemia: Molecular Approaches to Research and Therapy

1992 • 15 citations

Intensive chemotherapy, total body irradiation, and autologous marrow transplantation for chronic granulocytic leukemia-blast phase: report of four additional cases.

1984 • 15 citations

Adhesive Defects in Chronic Myeloid Leukemia

1989 • 13 citations

ABL proteins in Philadelphia‐positive acute leukaemias and chronic myelogenous leukaemia blast crises

1990 • 12 citations

Apparent decrease and elimination of BCR/ABL mRNA-expressing residual cells in patients with chronic myelogenous leukemia after allogeneic bone marrow transplantation

1991 • 11 citations

A 13-Years Remission in Chronic Myelocytic Leukemia after a Single Course of Busulfan

1978 • 9 citations

The bcr gene is joined to c-abl in Ph1 chromosome negative chronic myelogenous leukemia.

1988 • 5 citations

Deleted Work

1955 • 0 citations