Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Cleavage of structural proteins during the assemble of the head of bacterio-phage T4

1970 • 5,738 citations

Rapid Isolation of Antigens from Cells with A Staphylococcal Protein A-Antibody Adsorbent: Parameters of the Interaction of Antibody-Antigen Complexes with Protein A

1975 • 3,054 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,228 citations

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture

1977 • 2,134 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

1983 • 848 citations

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

1983 • 743 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine

1980 • 539 citations

Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: Studies with cloned viral DNA

1980 • 474 citations

Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro.

1984 • 405 citations

The erbB gene of avian erythroblastosis virus is a member of the src gene family

1983 • 377 citations

Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src).

1981 • 363 citations

Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation.

1982 • 337 citations

Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.

1985 • 282 citations

Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells.

1978 • 266 citations

Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

1984 • 239 citations

The mouse c-abl locus: Molecular cloning and characterization

1984 • 223 citations

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

1984 • 194 citations

Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line.

1982 • 193 citations

Local mutagenesis of Rous sarcoma virus: The major sites of tyrosine and serine phosphorylation of p60src are dispensable for transformation

1983 • 189 citations

The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity

1985 • 184 citations

Four Different Classes of Retroviruses Induce Phosphorylation of Tyrosines Present in Similar Cellular Proteins

1981 • 178 citations

Low Level of Cellular Protein Phosphorylation by Nontransforming Overproduced p60^c-src

1985 • 176 citations

Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties.

1985 • 162 citations

Protein phosphorylation at tyrosine is induced by the v-erbB gene product in vivo and in vitro

1985 • 160 citations

A normal cell protein cross-reactive to the major Abelson murine leukaemia virus gene product

1979 • 146 citations

Phosphorylation of tyrosine-416 is not required for the transforming properties and kinase activity of pp60v-src

1983 • 138 citations

Hormonal regulation of the rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation

1984 • 132 citations

The stimulation of pp60v-src kinase activity by vanadate in intact cells accompanies a new phosphorylation state of the enzyme.

1984 • 121 citations

Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity

1984 • 119 citations

A cellular protein is immunologically crossreactive with and functionally homologous to the Fujinami sarcoma virus transforming protein

1982 • 113 citations

Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine.

1981 • 113 citations

The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein

1983 • 109 citations

Viral and cellular src genes contribute to the structure of recovered avian sarcoma virus transforming protein

1981 • 104 citations

Expression of an Abelson murine leukemia virus-encoded protein in Escherichia coli causes extensive phosphorylation of tyrosine residues.

1982 • 99 citations

Purification and characterization of a protein-tyrosine kinase encoded by the Abelson murine leukemia virus.

1985 • 90 citations

In vivo tyrosine phosphorylations of the abelson virus transforming protein are absent in its normal cellular homolog

1982 • 86 citations

Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins.

1981 • 84 citations

P85 ^gag-mos encoded by ts110 Moloney murine sarcoma virus has an associated protein kinase activity

1983 • 79 citations

Structurally and Functionally Modified Forms of pp60^v-src in Rous Sarcoma Virus-Transformed Cell Lysates

1984 • 68 citations

The human v-abl cellular homologue.

1983 • 64 citations

Karyotypic, Virologic, and Immunologic Analyses of Two Continuous Lymphocyte Lines Established from New Zealand Black Mice: Possible Relationship of Chromosomal Mosaicism to Autoimmunity

1972 • 60 citations

Phosphorylation of the Abelson murine leukemia virus transforming protein

1981 • 32 citations

Two structurally and functionally different forms of the transforming protein of PRC II avian sarcoma virus.

1982 • 22 citations

A membrane-associated, carbohydrate-modified form of the v-abl protein that cannot be phosphorylated in vivo or in vitro

1984 • 21 citations

Two Structurally and Functionally Different Forms of the Transforming Protein of PRC II Avian Sarcoma Virus

1982 • 10 citations