Towards a glutamate hypothesis of depression

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DESCARTES?? ERROR: Emotion, Reason, and the Human Brain

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Stress and the brain: from adaptation to disease

2005 • 4,321 citations

mTOR: from growth signal integration to cancer, diabetes and ageing

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Evaluation of Outcomes With Citalopram for Depression Using Measurement-Based Care in STAR*D: Implications for Clinical Practice

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A PROPOSED MECHANISM OF EMOTION

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Antidepressant effects of ketamine in depressed patients

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A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

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THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

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Neurobiology of emotion perception I: the neural basis of normal emotion perception

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On the relationship between emotion and cognition

2008 • 2,034 citations

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2000 • 1,874 citations

Learning Induces Long-Term Potentiation in the Hippocampus

2006 • 1,841 citations

Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms

2007 • 1,827 citations

Experience-dependent structural synaptic plasticity in the mammalian brain

2009 • 1,815 citations

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

2011 • 1,749 citations

Neurobiology of emotion perception II: implications for major psychiatric disorders

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Emotion and Cognition: Insights from Studies of the Human Amygdala

2005 • 1,673 citations

Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

2007 • 1,669 citations

Chronic Stress Induces Contrasting Patterns of Dendritic Remodeling in Hippocampal and Amygdaloid Neurons

2002 • 1,607 citations

Glial reduction in the subgenual prefrontal cortex in mood disorders

1998 • 1,497 citations

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.

1999 • 1,450 citations

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

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Double Dissociation of Conditioning and Declarative Knowledge Relative to the Amygdala and Hippocampus in Humans

1995 • 1,386 citations

The glutamate homeostasis hypothesis of addiction

2009 • 1,255 citations

Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons

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Psychosomatic Disease and the "Visceral Brain"

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Norepinephrine in Depressive Reactions

1965 • 1,127 citations

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

2007 • 1,106 citations

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2008 • 1,079 citations

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

2007 • 1,050 citations

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

2011 • 1,025 citations

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

2010 • 911 citations

The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation

2009 • 906 citations

Stress-Induced Alterations in Prefrontal Cortical Dendritic Morphology Predict Selective Impairments in Perceptual Attentional Set-Shifting

2006 • 895 citations

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

2008 • 854 citations

Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of glucocorticoid secretion and excitatory amino acid receptors

1995 • 849 citations

Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies

2009 • 842 citations

Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells

2000 • 810 citations

Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy

2007 • 809 citations

Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression

2004 • 764 citations

Functional antagonists at the NMDA receptor complex exhibit antidepressant actions

1990 • 754 citations

Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone

2005 • 749 citations

Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex

2004 • 749 citations

The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law

2007 • 703 citations

Glucocorticoids, depression, and mood disorders: structural remodeling in the brain

2005 • 671 citations

Activity-dependent regulation of dendritic growth and patterning

2002 • 632 citations

Impaired fear conditioning following unilateral temporal lobectomy in humans

1995 • 631 citations

Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala

2005 • 627 citations

Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression

2005 • 617 citations

Depression: a case of neuronal life and death?

2004 • 609 citations

Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy.

1999 • 596 citations

Gliogenesis and Glial Pathology in Depression

2007 • 580 citations

Increased Levels of Glutamate in Brains from Patients with Mood Disorders

2007 • 578 citations

Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder

2001 • 568 citations

Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study

2000 • 567 citations

Stress Preferentially Increases Extraneuronal Levels of Excitatory Amino Acids in the Prefrontal Cortex: Comparison to Hippocampus and Basal Ganglia

1993 • 565 citations

The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling

2008 • 556 citations

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

2008 • 552 citations

Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy.

1999 • 541 citations

GABAergic dysfunction in mood disorders

2003 • 541 citations

Structural brain abnormalities in major depressive disorder: A selective review of recent MRI studies

2009 • 529 citations

An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder

2008 • 498 citations

Low glial numbers in the amygdala in major depressive disorder

2002 • 494 citations

Initiation and adaptation: a paradigm for understanding psychotropic drug action

1996 • 489 citations

Magnetic Resonance Spectroscopy Studies of Glutamate-Related Abnormalities in Mood Disorders

2010 • 459 citations

Glial cell abnormalities in major psychiatric disorders: the evidence and implications

2001 • 455 citations

Brain Metabolic Alterations in Medication-Free Patients With BipolarDisorder

2004 • 447 citations

Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory

2009 • 442 citations

Stress-induced prefrontal reorganization and executive dysfunction in rodents

2008 • 438 citations

Recovery after chronic stress fails to reverse amygdaloid neuronal hypertrophy and enhanced anxiety-like behavior

2004 • 435 citations

Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole

2008 • 433 citations

The Revised Monoamine Theory of Depression: A Modulatory Role for Monoamines, Based on New Findings From Monoamine Depletion Experiments in Humans

1996 • 382 citations

Mapping the Matrix: The Ways of Neocortex

2007 • 375 citations

Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex

2007 • 373 citations

The Stressed CNS: When Glucocorticoids Aggravate Inflammation

2009 • 373 citations

Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

2009 • 370 citations

Antidepressants for the new millennium

1999 • 358 citations

Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes

2004 • 356 citations

Rapid Communication: Adrenalectomy Attenuates Stress‐Induced Elevations in Extracellular Glutamate Concentrations in the Hippocampus

1993 • 345 citations

Chronic Social Stress Inhibits Cell Proliferation in the Adult Medial Prefrontal Cortex: Hemispheric Asymmetry and Reversal by Fluoxetine Treatment

2006 • 344 citations

Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression

2010 • 336 citations

Decreased dendritic spine density on prefrontal cortical and hippocampal pyramidal neurons in postweaning social isolation rats

2003 • 329 citations

Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling

2010 • 329 citations

Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat

2007 • 329 citations

Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder

2000 • 327 citations

Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

2011 • 327 citations

Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress

2005 • 310 citations

Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory

2010 • 308 citations

Correlation between plasma levels of glutamate, alanine and serine with severity of depression

2006 • 305 citations

Acute Stress-induced Changes in Hippocampal/Prefrontal Circuits in Rats: Effects of Antidepressants

2003 • 303 citations

Reduction in Occipital Cortex γ-Aminobutyric Acid Concentrations in Medication-Free Recovered Unipolar Depressed and Bipolar Subjects

2007 • 295 citations

Volumetric neuroimaging investigations in mood disorders: bipolar disorder versus major depressive disorder

2008 • 290 citations

Acute Stress Increases Depolarization-Evoked Glutamate Release in the Rat Prefrontal/Frontal Cortex: The Dampening Action of Antidepressants

2010 • 287 citations

Positive Modulation of AMPA Receptors Increases Neurotrophin Expression by Hippocampal and Cortical Neurons

2000 • 283 citations

Rapid glucocorticoid effects on excitatory amino acid levels in the hippocampus: a microdialysis study in freely moving rats

1999 • 282 citations

The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation

2008 • 268 citations

Abnormal Glutamatergic Neurotransmission and Neuronal-Glial Interactions in Acute Mania

2008 • 265 citations

Age-Dependent Reductions in the Level of Glial Fibrillary Acidic Protein in the Prefrontal Cortex in Major Depression

2004 • 250 citations

Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus

2001 • 247 citations

Metabolic changes within the left dorsolateral prefrontal cortex occurring with electroconvulsive therapy in patients with treatment resistant unipolar depression

2003 • 243 citations

Plasma and platelet excitatory amino acids in psychiatric disorders

1993 • 243 citations

Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.

1994 • 241 citations

Reduced Anterior Cingulate Glutamatergic Concentrations in Childhood OCD and Major Depression Versus Healthy Controls

2004 • 236 citations

How can drug discovery for psychiatric disorders be improved?

2007 • 236 citations

Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam

1997 • 235 citations

Plasma and Platelet Amino Acid Concentrations in Patients Affected by Major Depression and under Fluvoxamine Treatment

1998 • 233 citations

Increased cerebrospinal fluid glutamine levels in depressed patients

2000 • 232 citations

Chronic Antidepressants Reduce Depolarization-Evoked Glutamate Release and Protein Interactions Favoring Formation of SNARE Complex in Hippocampus

2005 • 232 citations

A role for AMPA receptors in mood disorders

2006 • 226 citations

Distribution, morphology and number of monoamine-synthesizing and substance P-containing neurons in the human dorsal raphe nucleus

1991 • 220 citations

Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: Reversal by tianeptine

2004 • 218 citations

Increased Anterior Cingulate/Medial Prefrontal Cortical Glutamate and Creatine in Bipolar Depression

2007 • 218 citations

A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3, and BDNF

2008 • 211 citations

Functional actions of corticosteroids in the hippocampus

2008 • 207 citations

Prolonged effect of an anesthetic dose of ketamine on behavioral despair

2002 • 204 citations

Glial and glutamatergic markers in depression, alcoholism, and their comorbidity

2010 • 204 citations

Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression

2008 • 202 citations

Neurotrophic Effects of Electroconvulsive Therapy: A Proton Magnetic Resonance Study of the Left Amygdalar Region in Patients with Treatment-Resistant Depression

2002 • 196 citations

Stress-induced structural remodeling in hippocampus: Prevention by lithium treatment

2004 • 196 citations

Acute stress‐mediated increases in extracellular glutamate levels in the rat amygdala: differential effects of antidepressant treatment

2007 • 194 citations

An update on regional brain volume differences associated with mood disorders

2005 • 193 citations

Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.

1993 • 192 citations

Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex

2003 • 191 citations

Rapid changes in hippocampal CA1 pyramidal cell function via pre‐ as well as postsynaptic membrane mineralocorticoid receptors

2008 • 188 citations

Increased serum glutamate in depressed patients

1982 • 186 citations

Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression

1995 • 186 citations

Understanding Synapses: Past, Present, and Future

2008 • 185 citations

The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [1H]-MRS

2011 • 184 citations

Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory

2010 • 184 citations

Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations.

2000 • 182 citations

Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment‐resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity

1998 • 176 citations

Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder

2008 • 174 citations

Overcoming the Effects of Stress on Synaptic Plasticity in the Intact Hippocampus: Rapid Actions of Serotonergic and Antidepressant Agents

2002 • 174 citations

Immunohistochemical Localization of Phosphorylated Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus from Patients with Schizophrenia, Bipolar Disorder, and Depression

2001 • 173 citations

Neural correlates of emotion regulation in psychopathology

2007 • 171 citations

Specific Configuration of Dendritic Degeneration in Pyramidal Neurons of the Medial Prefrontal Cortex Induced by Differing Corticosteroid Regimens

2006 • 169 citations

Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression

2009 • 164 citations

Modulation of Synaptic Plasticity by Antimanic Agents: The Role of AMPA Glutamate Receptor Subunit 1 Synaptic Expression

2004 • 161 citations

Cellular and molecular mechanisms in the long-term action of antidepressants.

2008 • 159 citations

Altered dendritic spine density in animal models of depression and in response to antidepressant treatment

2001 • 159 citations

Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain

1998 • 158 citations

Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder

2010 • 151 citations

Repeated ECS and fluoxetine administration have equivalent effects on hippocampal synaptic plasticity

2000 • 150 citations

The chemical nature of the main central excitatory transmitter: A critical appraisal based upon release studies and synaptic vesicle localization

1993 • 147 citations

Low Cerebrospinal Fluid Glutamate and Glycine in Refractory Affective Disorder

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Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals

2008 • 146 citations

Microdialysis of GABA and glutamate: Analysis, interpretation and comparison with microsensors

2007 • 145 citations

The change in plasma GABA, glutamine and glutamate levels in fluoxetine- or S-citalopram-treated female patients with major depression

2009 • 144 citations

Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action.

2008 • 144 citations

Glia pathology in the prefrontal cortex in alcohol dependence with and without depressive symptoms

2002 • 141 citations

Proton Magnetic Resonance Spectroscopy of Bipolar Disorder Versus Intermittent Explosive Disorder in Children and Adolescents

2003 • 139 citations

Stress-induced dendritic remodeling in the medial prefrontal cortex: Effects of circuit, hormones and rest

2009 • 138 citations

Social Stress in Tree Shrews as an Animal Model of Depression: An Example of a Behavioral Model of a CNS Disorder

2005 • 138 citations

Modulation of synaptic plasticity by stress and antidepressants

2002 • 138 citations

Differential Promotion of Glutamate Transporter Expression and Function by Glucocorticoids in Astrocytes from Various Brain Regions

2005 • 136 citations

Cell pathology in mood disorders

2002 • 133 citations

Reduced Anterior Cingulate Glutamate in Pediatric Major Depression: A Magnetic Resonance Spectroscopy Study

2005 • 133 citations

Glial fibrillary acidic protein is reduced in cerebellum of subjects with major depression, but not schizophrenia

2003 • 132 citations

Corticosterone Alters AMPAR Mobility and Facilitates Bidirectional Synaptic Plasticity

2009 • 130 citations

GABAergic Contributions to the Pathophysiology of Depression and the Mechanism of Antidepressant Action

2007 • 128 citations

Reduced Anterior Cingulate Cortex Glutamatergic Concentrations in Childhood Major Depression

2004 • 127 citations

Long-term effects of early life deprivation on brain glia in Fischer rats

2007 • 122 citations

Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders

2008 • 122 citations

Chronic antidepressant treatment increases the membrane expression of AMPA receptors in rat hippocampus

2002 • 122 citations

Thinking Glutamatergically: Changing Concepts of Schizophrenia Based Upon Changing Neurochemical Models

2010 • 117 citations

Rapid microelectrode measurements and the origin and regulation of extracellular glutamate in rat prefrontal cortex

2010 • 111 citations

Stress, glucocorticoids and glutamate release: Effects of antidepressant drugs

2011 • 108 citations

Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex—a possible mechanism of neuroprotection in major depression?

2000 • 106 citations

Roles of glutamate signaling in preclinical and/or mechanistic models of depression

2011 • 99 citations

Brain amino acid concentrations and Ca2+-dependent release in intractable depression assessed antemortem

1989 • 99 citations

Cellular perspectives on the glutamate–monoamine interactions in limbic lobe structures and their relevance for some psychiatric disorders

2002 • 96 citations

Stress generates emotional memories and retrograde amnesia by inducing an endogenous form of hippocampal LTP

2004 • 96 citations

Prenatal stress and subsequent exposure to chronic mild stress influence dendritic spine density and morphology in the rat medial prefrontal cortex

2007 • 96 citations

Regulation of Editing and Expression of Glutamate α-Amino-Propionic-Acid (AMPA)/Kainate Receptors by Antidepressant Drugs

2006 • 95 citations

Glial fibrillary acidic protein and glutamine synthetase in subregions of prefrontal cortex in schizophrenia and mood disorder

2006 • 93 citations

Metabolic alterations in medication-free patients with bipolar disorder: A 3T CSF-corrected magnetic resonance spectroscopic imaging study

2008 • 89 citations

Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation

2008 • 86 citations

Lack of persistent effects of ketamine in rodent models of depression

2008 • 85 citations

Metabotropic glutamate receptor 7: At the interface of cognition and emotion

2010 • 85 citations

Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients

2008 • 84 citations

Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs

2009 • 82 citations

Glutamate transporters in platelets: EAAT1 decrease in aging and in Alzheimer’s disease

2003 • 79 citations

Single voxel proton magnetic resonance spectroscopy in post-stroke depression

2006 • 76 citations

Antidepressant treatments and function of glutamate ionotropic receptors mediating amine release in hippocampus

2007 • 75 citations

Repeated Restraint Stress Alters Hippocampal Glutamate Uptake and Release in the Rat

2004 • 75 citations

Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene–environment rat model of depression

2008 • 73 citations

Neurochemistry of late‐life major depression: A pilot two‐dimensional MR spectroscopic study

2004 • 70 citations

Glutamate level detection by magnetic resonance spectroscopy in patients with post-stroke depression

2011 • 67 citations

A Hypothesized Role for Dendritic Remodeling in the Etiology of Mood and Anxiety Disorders

2010 • 66 citations

Chronic imipramine treatment partially reverses the long-term changes of hippocampal synaptic plasticity in socially stressed rats

2001 • 66 citations

Repeated administration of imipramine attenuates glutamatergic transmission in rat frontal cortex

2008 • 63 citations

Enhancing AMPA to NMDA throughput as a convergent mechanism for antidepressant action

2006 • 60 citations

Modulation of presynaptic glucocorticoid receptors on glutamate release from rat hippocampal nerve terminals

2009 • 59 citations

Fluoxetine depresses glutamate exocytosis in the rat cerebrocortical nerve terminals (synaptosomes) via inhibition of P/Q‐type Ca²⁺ channels

2003 • 59 citations

The Antidepressant Sertraline Inhibits Translation Initiation by Curtailing Mammalian Target of Rapamycin Signaling

2010 • 59 citations

Fluvoxamine suppresses the long-term potentiation in the hippocampal CA1 field of anesthetized rats: an effect mediated via 5-HT1A receptors

2002 • 57 citations

Acute stress disrupts paired pulse facilitation and long‐term potentiation in rat dorsal hippocampus through activation of glucocorticoid receptors

2009 • 55 citations

Glia atrophy in the hippocampus of chronic unpredictable stress-induced depression model rats is reversed by electroacupuncture treatment

2010 • 54 citations

Central GABAergic systems and depressive illness.

2003 • 53 citations

Chronic Antidepressants Induce Redistribution and Differential Activation of αCaM Kinase II between Presynaptic Compartments

2007 • 51 citations

Changes in synaptic plasticity in the rat hippocampo-medial prefrontal cortex pathway induced by repeated treatments with fluvoxamine

2002 • 51 citations

CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy

2011 • 49 citations

Allosteric modulation of the effects of the 5-HT reuptake inhibitor escitalopram on the rat hippocampal synaptic plasticity

2005 • 46 citations

Review: Magnetic Resonance Spectroscopy Studies of Pediatric Major Depressive Disorder

2010 • 45 citations

Do Stress and Long-Term Potentiation Share the Same Molecular Mechanisms?

2005 • 44 citations

Effects of Depressive-Like Behavior of Rats on Brain Glutamate Uptake

2010 • 43 citations

Selective regulation of presynaptic Calcium/Calmodulin-Dependent protein kinase II by psychotropic drugs

2003 • 41 citations

Correlation of Findings in Advanced MRI Techniques with Global Severity Scales in Patients with Parkinson Disease

2011 • 40 citations

Milnacipran, a serotonin and noradrenaline reuptake inhibitor, suppresses long-term potentiation in the rat hippocampal CA1 field via 5-HT1A receptors and α1-adrenoceptors

2004 • 39 citations

Substrate‐induced modulation of glutamate uptake in human platelets

2005 • 32 citations

Chronic treatment with milnacipran reverses the impairment of synaptic plasticity induced by conditioned fear stress

2004 • 32 citations

Elevated cortical glutamate in young people at increased familial risk of depression

2010 • 32 citations

Chronic Stress and Lithium Treatments Alter Hippocampal Glutamate Uptake and Release in the Rat and Potentiate Necrotic Cellular Death After Oxygen and Glucose Deprivation

2011 • 31 citations

Lack of NMDA–AMPA interaction in antidepressant-like effect of CGP 37849, an antagonist of NMDA receptor, in the forced swim test

2008 • 29 citations

Acute Restraint Stress Enhances Calcium Mobilization and Glutamate Exocytosis in Cerebrocortical Synaptosomes from Mice

2010 • 25 citations

Neurobiochemical changes from Taxol/Neupogen chemotherapy for metastatic breast carcinoma corresponds with suicidal depression

1996 • 25 citations

Inhibition of glutamate release by bupropion in rat cerebral cortex nerve terminals

2011 • 24 citations

Interaction between N-methyl-D-aspartate receptor antagonists and imipramine in shock-induced depression.

1999 • 23 citations

Serum proinflammatory cytokines correlate with diffusion tensor imaging derived metrics and 1H-MR spectroscopy in patients with acute liver failure

2010 • 22 citations

BRAIN FUNCTIONS AND PSYCHIATRIC DISORDERS

1998 • 19 citations

Tolerance to the sedative effect of lorazepam correlates with a diminution in cortical release and affinity for glutamate

2002 • 19 citations

Adaptive changes in the rat hippocampal glutamatergic neurotransmission are observed during long-term treatment with lorazepam

2003 • 17 citations

Changes in [3H]-glutamate uptake into platelets from patients with bipolar I disorder

2006 • 13 citations

Peripheral Markers of Glutamatergic Dysfunction in Neurological Diseases: Focus on Ex Vivo Tools

2004 • 6 citations