Depression: a case of neuronal life and death?

Mammalian Neural Stem Cells

2000 • 4,689 citations

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

2003 • 4,175 citations

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1999 • 3,805 citations

Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus

2000 • 3,047 citations

Functional neurogenesis in the adult hippocampus

2002 • 2,813 citations

Subgenual prefrontal cortex abnormalities in mood disorders

1997 • 2,646 citations

STRESS AND HIPPOCAMPAL PLASTICITY

1999 • 2,023 citations

Hippocampal atrophy in recurrent major depression.

1996 • 1,884 citations

Stress and cognitive function

1995 • 1,830 citations

Hippocampal Volume Reduction in Major Depression

2000 • 1,645 citations

Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus

2001 • 1,554 citations

Glial reduction in the subgenual prefrontal cortex in mood disorders

1998 • 1,497 citations

Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation

1997 • 1,468 citations

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.

1999 • 1,450 citations

Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress

1998 • 1,386 citations

Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression

1999 • 1,371 citations

Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states

2002 • 1,241 citations

The cellular neurobiology of depression

2001 • 1,169 citations

Untreated Depression and Hippocampal Volume Loss

2003 • 1,140 citations

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

2001 • 1,136 citations

Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine

2001 • 1,082 citations

Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus

2000 • 1,022 citations

Course of illness, hippocampal function, and hippocampal volume in major depression

2003 • 962 citations

Estrogen Stimulates a Transient Increase in the Number of New Neurons in the Dentate Gyrus of the Adult Female Rat

1999 • 958 citations

Hippocampal neurogenesis in adult Old World primates

1999 • 804 citations

Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment

2003 • 796 citations

Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis

2003 • 788 citations

Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects

2003 • 783 citations

Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder

2001 • 754 citations

Increased neurogenesis in a model of electroconvulsive therapy

2000 • 726 citations

Restoring production of hippocampal neurons in old age

1999 • 717 citations

Cell Proliferation Without Neurogenesis in Adult Primate Neocortex

2001 • 714 citations

Neuronal plasticity and survival in mood disorders

2000 • 658 citations

Repeated restraint stress suppresses neurogenesis and induces biphasic PSA‐NCAM expression in the adult rat dentate gyrus

2003 • 641 citations

Adrenal hormones suppress cell division in the adult rat dentate gyrus

1992 • 638 citations

Hippocampal Changes in Patients With a First Episode of Major Depression

2002 • 506 citations

3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity

2000 • 486 citations

Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder

2003 • 480 citations

Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein

2002 • 478 citations

Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile Rhesus monkeys

2003 • 463 citations

Animal models of depression: An overview

1990 • 425 citations

Cortical grey matter reductions associated with treatment-resistant chronic unipolar depression

1998 • 401 citations

Adult-generated hippocampal and neocortical neurons in macaques have a transient existence

2001 • 394 citations

Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway

1997 • 381 citations

Quantitative MRI of the hippocampus and amygdala in severe depression

2000 • 377 citations

Hippocampal volume in geriatric depression

2000 • 371 citations

Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone‐dependent mechanism

2001 • 367 citations

Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study

2000 • 360 citations

Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesis

2002 • 355 citations

Blockade of CRF1 or V1b receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression

2003 • 309 citations

Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone‐induced suppression

2002 • 295 citations

Regulation of adult neurogenesis by psychotropic drugs and stress.

2001 • 288 citations

Hypercortisolemia and hippocampal changes in depression

1993 • 284 citations

Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task

2002 • 283 citations

Localization of Phosphorylated cAMP Response Element-Binding Protein in Immature Neurons of Adult Hippocampus

2002 • 269 citations

The Role of the Dorsal Hippocampal Serotonergic and Cholinergic Systems in the Modulation of Anxiety

2000 • 246 citations

Reduced cell proliferation in the dentate gyrusis not correlated with the development of learned helplessness

2003 • 222 citations

Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro

2001 • 221 citations

Fluoxetine enhances cell proliferation and prevents apoptosis in dentate gyrus of maternally separated rats

2001 • 205 citations

High-Dimensional Mapping of the Hippocampus in Depression

2002 • 201 citations

Activation of cAMP Signaling Facilitates the Morphological Maturation of Newborn Neurons in Adult Hippocampus

2004 • 190 citations

Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume

2002 • 157 citations

Nonrenewal of Neurons in the Cerebral Neocortex of Adult Macaque Monkeys

2003 • 154 citations

Anxiolytic effects of cytotoxic hippocampal lesions in rats.

2002 • 127 citations

Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests

2002 • 117 citations

Anxiolytic effects of cytotoxic hippocampal lesions in rats.

2002 • 99 citations

Animal models of depression

1990 • 95 citations

Chickens, eggs and hippocampal atrophy

2002 • 75 citations

The anxiolytic effects of intra-hippocampal midazolam are antagonized by intra-septal l-glutamate

2001 • 73 citations

Abnormal, abusive, and stress-related behaviors in baboon mothers

2002 • 46 citations