Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

1995 • 93,704 citations

Gene Ontology: tool for the unification of biology

2000 • 38,297 citations

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

1995 • 9,575 citations

DAVID: Database for Annotation, Visualization, and Integrated Discovery

2003 • 8,668 citations

A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

2006 • 3,477 citations

The world health report 2000 - Health systems: improving performance

2000 • 3,265 citations

Expression monitoring by hybridization to high-density oligonucleotide arrays

1996 • 2,796 citations

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders

2000 • 1,927 citations

Hippocampal Volume Reduction in Major Depression

2000 • 1,645 citations

Microarray data analysis: from disarray to consolidation and consensus

2005 • 1,361 citations

Neuroimaging studies of mood disorders

2000 • 1,303 citations

Neurobiology of suicidal behaviour

2003 • 1,197 citations

The cellular neurobiology of depression

2001 • 1,169 citations

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

2001 • 1,136 citations

Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis

2004 • 1,101 citations

Course of illness, hippocampal function, and hippocampal volume in major depression

2003 • 962 citations

Ontological analysis of gene expression data: current tools, limitations, and open problems

2005 • 867 citations

Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy

2007 • 809 citations

Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression

2004 • 764 citations

The anatomy of mood disorders—review of structural neuroimaging studies

1997 • 764 citations

Limbic–frontal circuitry in major depression: a path modeling metanalysis

2004 • 701 citations

Neuroimaging studies of mood disorder effects on the brain

2003 • 654 citations

Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression

2000 • 651 citations

Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression

2005 • 617 citations

Gliogenesis and Glial Pathology in Depression

2007 • 580 citations

Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study

2000 • 567 citations

Book Review: GABA and Glutamate in the Human Brain

2002 • 554 citations

GABAergic dysfunction in mood disorders

2003 • 541 citations

Reduced volume of orbitofrontal cortex in major depression

2002 • 534 citations

Neurobiology of Mental Illness

2011 • 532 citations

Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments

2002 • 532 citations

World Health Report 2000: a step towards evidence-based health policy

2001 • 525 citations

Functional Neuroimaging Studies of Depression: The Anatomy of Melancholia

1998 • 503 citations

Interactions of polyamines with ion channels

1997 • 493 citations

3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity

2000 • 486 citations

The neurobiology of suicide

1998 • 475 citations

Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression

1997 • 424 citations

Don't worry ‘B’ happy!: a role for GABAB receptors in anxiety and depression

2004 • 405 citations

Activation of Prefrontal Cortex and Anterior Thalamus in Alcoholic Subjects on Exposure to Alcohol-Specific Cues

2001 • 391 citations

The Neurobiology and Genetics of Suicide and Attempted Suicide: A Focus on the Serotonergic System

2001 • 390 citations

Dysregulation in the Suicide Brain: mRNA Expression of Corticotropin-Releasing Hormone Receptors and GABA_AReceptor Subunits in Frontal Cortical Brain Region

2004 • 378 citations

Neurobiology of Mental Illness.

2000 • 344 citations

Reduced activation and expression of ERK1/2 MAP kinase in the post‐mortem brain of depressed suicide subjects

2001 • 319 citations

NORADRENALINE, 5-HYDROXYTRYPTAMINE, AND 5-HYDROXYINDOLEACETIC ACID IN HINDBRAINS OF SUICIDAL PATIENTS

1968 • 304 citations

ErmineJ: Tool for functional analysis of gene expression data sets

2005 • 277 citations

Prediction of Level of Serotonin 2A Receptor Binding by Serotonin Receptor 2A Genetic Variation in Postmortem Brain Samples From Subjects Who Did or Did Not Commit Suicide

1999 • 274 citations

Acute and chronic ethanol treatment changes endorphin levels in brain and pituitary

1980 • 267 citations

Alterations in the N-methyl-d-asparatate (NMDA) receptor complex in the frontal cortex of suicide victims

1995 • 263 citations

5-HYDROXYTRYPTAMINE, NORADRENALINE, AND DOPAMINE IN BRAINSTEM, HYPOTHALAMUS, AND CAUDATE NUCLEUS OF CONTROLS AND OF PATIENTS COMMITTING SUICIDE BY COAL-GAS POISONING

1969 • 259 citations

Statistical Methods for Identifying Differentially Expressed Genes in DNA Microarrays

2003 • 255 citations

LOW PREVALENCE OF HUNTINGTONS-DISEASE IN FINLAND

1900 • 254 citations

Effects of filtering by Present call on analysis of microarray experiments

2006 • 243 citations

Genetic Markers of Suicidal Ideation Emerging During Citalopram Treatment of Major Depression

2007 • 213 citations

THE COMPULSIVE GAMBLER.

1964 • 202 citations

Structure of the Human Brain. A Photographic Atlas.

1974 • 200 citations

Polyamine-dependent facilitation of postsynaptic AMPA receptors counteracts paired-pulse depression

1999 • 192 citations

The Hippocampus and Parahippocampus in Schizophrenic, Suicide, and Control Brains

1990 • 187 citations

Neuroanatomic Correlates of Psychopathologic Components of Major Depressive Disorder

2005 • 180 citations

Familial Aggregation of Suicidal Behavior: A Family Study of Male Suicide Completers From the General Population

2005 • 175 citations

G proteins: implications for psychiatry

1992 • 172 citations

α2-Adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression

1992 • 171 citations

Implication of SSAT by Gene Expression and Genetic Variation in Suicide and Major Depression

2006 • 169 citations

The hippocampus and depression

2002 • 163 citations

Differential effects of acute and chronic ethanol treatment on particular opioid peptide systems in discrete regions of rat brain and pituitary

1983 • 146 citations

Suicidal behavior: is there a genetic predisposition?

2001 • 138 citations

Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression

1999 • 133 citations

Microarray Technology: A Review of New Strategies to Discover Candidate Vulnerability Genes in Psychiatric Disorders

2003 • 132 citations

Suicide Over the Life Cycle: Risk Factors, Assessment, and Treatment of Suicidal Patients

1991 • 131 citations

Recent advances in the neurobiology of depression.

2002 • 131 citations

Increased mRNA Expression of α2A-Adrenoceptors, Serotonin Receptors and μ-Opioid Receptors in the Brains of Suicide Victims

2004 • 127 citations

Suicide over the life cycle : risk factors, assessment, and treatment of suicidal patients

1990 • 126 citations

Gene Expression Profiling of Depression and Suicide in Human Prefrontal Cortex

2003 • 123 citations

ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf

2005 • 121 citations

Comprehensive sampling of gene expression in human cell lines with massively parallel signature sequencing

2003 • 116 citations

Quantitative autoradiography of α1- and α2-adrenergic receptors in the cerebral cortex of controls and suicide victims

1993 • 104 citations

Structure of the Human Brain. A Photographic Atlas

1990 • 104 citations

Glutamate receptors in the postmortem striatum of schizophrenic, suicide, and control brains

1997 • 99 citations

Brain GABAA/benzodiazepine binding sites and glutamic acid decarboxylase activity in depressed suicide victims

1988 • 95 citations

Increased? 2;-adrenoceptor density in the frontal cortex of depressed suicide victims

1987 • 95 citations

Overview of the World Health Report 2000 Health systems: improving performance.

2002 • 85 citations

Protein kinase a in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits

2004 • 85 citations

Bias in the estimation of false discovery rate in microarray studies

2005 • 83 citations

Dopamine D1 and D2 receptor binding sites in brain samples from depressed suicides and controls

1997 • 74 citations

The suicide brain: a review of postmortem receptor/transporter binding studies

1998 • 71 citations

Decreased Catalytic Activity and Expression of Protein Kinase C Isozymesin Teenage Suicide Victims

2004 • 71 citations

Platelet Glutamate Receptor Supersensitivity in Major Depressive Disorder

2001 • 63 citations

NMDA glutamatergic receptors, labelled with [3H]MK-801, in brain samples from drug-free depressed suicides

1993 • 61 citations

mRNA and Protein Expression of Selective Alpha Subunits of G Proteins are Abnormal in Prefrontal Cortex of Suicide Victims

2002 • 59 citations

Imaging serotonergic neurotransmission in depression: hippocampal pathophysiology may mirror global brain alterations

2000 • 50 citations

Structure of the human brain: A photographic atlas, 3rd ed.

1989 • 47 citations

Pathophysiology of the Locus Coeruleus in Suicide^a

1997 • 47 citations

Brain Region Specific Alterations in the Protein and mRNA Levels of Protein Kinase A Subunits in the Post-Mortem Brain of Teenage Suicide Victims

2005 • 46 citations

Antidepressant mechanisms: functional and molecular correlates of excitatory amino acid neurotransmission

2002 • 45 citations

An activity-dependent spermine-mediated mechanism that modulates glutamate transmission

2002 • 45 citations

Recent Advances in the Neurobiology of Depression

2003 • 38 citations

DRD4 receptor gene exon III polymorphism in inpatient suicidal adolescents

2004 • 29 citations

Spermine modulation of the glutamate_{<scp>nmda</scp>} receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex

2002 • 29 citations

Suicidal behavior in depression: Relationship to noradrenergic function

1989 • 29 citations

Polyamines Modulate the Binding of [³H]MK‐801 to the Solubilized N‐Methyl‐D‐Aspartate Receptor

1991 • 28 citations

Linkage disequilibrium analysis of childhood-onset spinal muscular atrophy (SMA) in the French — Canadian population

1994 • 25 citations

The World Health Report 2000: Health Systems: Improving Performance, Geneva: World Health Organization; 2000, 150 pages plus tables; $13.50; available on-line from: URL:

2001 • 22 citations

Chronic Ethanol Self-Administration in a Continuous-Access Operant Situation

1999 • 22 citations

Spermine depresses NMDA, K/AMPA and GABAA-mediated synaptic transmission in the rat hippocampal slice preparation

1994 • 18 citations

Molecular characterization of suicide by microarray analysis

2005 • 14 citations

Suicide-attempters having immunoglobulin G with affinity for dopamine in cerebrospinal fluid

2002 • 12 citations